Publications by authors named "Colin Macphee"

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Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders.
Colin H Macphee, Xinzhong Dong, Qi Peng, Daniel V Paone, Per Stahl Skov

Front Immunol· November 2024

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The MRGPRX2-substance P pathway regulates mast cell migration.
Peter W West, Jérémy Chéret, Rajia Bahri, Orsolya Kiss, Zining Wu, Colin H Macphee

iScience· October 2024

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Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
Ann M Rowley, Gang Yao, Logan Andrews, Aaron Bedermann, Ross Biddulph, Colin Macphee

J Med Chem· February 2024

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Intradermal substance P as a challenge agent in healthy individuals.
Wouter Ten Voorde, Chika Akinseye, Ismahaan Abdisalaam, Selinde Wind, Naomi Klarenbeek, Colin Macphee

Clin Transl Sci· October 2023

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Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events.
Moneeza K Siddiqui, Gillian Smith, Pamela St Jean, Adem Y Dawed, Samira Bell, Colin H Macphee

Diabetologia· January 2022

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Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes.
François Béliveau, Aarti Tarkar, Sébastien P Dion, Antoine Désilets, Mariana Gabriela Ghinet, Colin H Macphee

Cell Chem Biol· November 2019

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Community-based statins and advanced carotid plaque: Role of CD163 positive macrophages in lipoprotein-associated phospholipase A activity in atherosclerotic plaque.
Fumiyuki Otsuka, XiaoQing Zhao, Hugh H Trout, Ye Qiao, Bruce A Wasserman, Colin H Macphee

Atherosclerosis· December 2017

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Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.
Astrid Yeo, Li Li, Liling Warren, Jennifer Aponte, Dana Fraser, Colin MacPhee

PLoS One· October 2017

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Retinal pathology is associated with increased blood-retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA inhibitor Darapladib.
Nimish K Acharya, Xin Qi, Eric L Goldwaser, George A Godsey, Hao Wu, Colin H Macphee

Diab Vasc Dis Res· May 2017

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Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.
Shun He, Benjamin G Chousterman, Ashley Fenn, Atsushi Anzai, Manfred Nairz, Colin Macphee

Circ Heart Fail· September 2015

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Atherosclerotic plaque inflammation varies between vascular sites and correlates with response to inhibition of lipoprotein-associated phospholipase A2.
Robert S Fenning, Mark E Burgert, Damir Hamamdzic, Eliot G Peyster, Emile R Mohler, Colin H Macphee

J Am Heart Assoc· February 2015

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Effect of darapladib treatment on endarterectomy carotid plaque lipoprotein-associated phospholipase A2 activity: a randomized, controlled trial.
Joel L Johnson, Yi Shi, Rose Snipes, Salim Janmohamed, Timothy E Rolfe, Colin H Macphee

PLoS One· January 2015

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Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials.
Bonnie C Shaddinger, Yanmei Xu, James H Roger, Colin H Macphee, Malcolm Handel

PLoS One· November 2014

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Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib.
Nimish K Acharya, Eli C Levin, Peter M Clifford, Min Han, Ryan Tourtellotte, Colin H Macphee

J Alzheimers Dis· December 2013

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Specificity of lipoprotein-associated phospholipase A(2) toward oxidized phosphatidylserines: liquid chromatography-electrospray ionization mass spectrometry characterization of products and computer modeling of interactions.
Vladimir A Tyurin, Naveena Yanamala, Yulia Y Tyurina, Judith Klein-Seetharaman, Colin H Macphee

Biochemistry· December 2012

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The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice.
Zhilong Jiang, Melane L Fehrenbach, Giulia Ravaioli, Blerina Kokalari, Imre G Redai, Colin Macphee

Respir Res· November 2012

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Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway.
Kazuhiro Nakaya, Junichiro Tohyama, Snehal U Naik, Hiroyuki Tanigawa, Colin MacPhee

Arterioscler Thromb Vasc Biol· June 2011

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PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI.
Sue-Anne Toh, John S Millar, Jeffrey Billheimer, Ilia Fuki, Snehal U Naik, Colin Macphee

Biochem Pharmacol· April 2011

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Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment.
Alan R Olzinski, Gregory H Turner, Roberta E Bernard, Heather Karr, Carla A Cornejo, Colin H Macphee

Arterioscler Thromb Vasc Biol· February 2010

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Lipoprotein-associated phospholipase A(2) and atherosclerosis.
Robert L Wilensky, Colin H Macphee

Curr Opin Lipidol· October 2009

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Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol.
François Briand, Snehal U Naik, Ilia Fuki, John S Millar, Colin Macphee

Clin Transl Sci· April 2009

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Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development.
Robert L Wilensky, Yi Shi, Emile R Mohler, Damir Hamamdzic, Mark E Burgert, Colin H Macphee

Nat Med· October 2008

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Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature.
Emile R Mohler, Lea Sarov-Blat, Yi Shi, Damir Hamamdzic, Andrew Zalewski, Colin Macphee

Arterioscler Thromb Vasc Biol· May 2008

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Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein.
Bill Davis, Grielof Koster, Lisa J Douet, Michaela Scigelova, Gary Woffendin, Colin H Macphee

J Biol Chem· March 2008

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Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells.
Nambi Aiyar, Jyoti Disa, Zhaohui Ao, Haisong Ju, Sandhya Nerurkar, Colin H Macphee

Mol Cell Biochem· January 2007

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