Publications by authors named "Colin T Shearn"

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Rapid protein carbonylation and decreased insulin secretion induced by inflammatory oxidative stress compounds.
Emma F Saunders, Katherine R Schultz, Isaiah Lowe, Aimee L Anderson, Vrishank S Bikkumalla, Colin T Shearn

Free Radic Biol Med· January 2026

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Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes.
Ashley Ling, Katherine R Schultz, Jefferson D Knight, Colin T Shearn, Sharon Baumel-Alterzon

Front Endocrinol (Lausanne)· December 2025

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Inflammatory Oxidative Stress Compounds Inhibit Insulin Secretion through Rapid Protein Carbonylation.
Emma F Saunders, Katherine R Schultz, Isaiah Lowe, Aimee L Anderson, Vrishank S Bikkumalla, Colin T Shearn

bioRxiv· July 2025

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Parenteral nutrition results in peripheral ileal to hepatic circadian discordance in mice.
Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Ronald J Sokol

Am J Physiol Gastrointest Liver Physiol· December 2024

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Overexpression of TNFα in TNF∆ARE+/- mice increases hepatic periportal inflammation and alters bile acid signaling in mice.
Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Samuel D Koch, Leigha D Larsen

Hepatol Commun· December 2024

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Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.
Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Karim C El Kasmi, David J Orlicky

PLoS One· September 2023

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Endocrine pancreas-specific gene deletion causes a severe diabetes phenotype.
Emily A Davidson, Ying Chen, Surendra Singh, David J Orlicky, Brian Thompson, Colin T Shearn

bioRxiv· June 2023

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Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.
Colin T Shearn, Aimee L Anderson, Colin G Miller, Reed C Noyd, Michael W Devereaux

Hepatol Commun· January 2023

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The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease.
Colin T Shearn, Aimee L Anderson, Michael W Devereux, David J Orlicky, Cole Michel

PLoS One· November 2022

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Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice.
Karim C El Kasmi, Aimee L Anderson, Michael W Devereaux, Natarajan Balasubramaniyan, Frederick J Suchy, Colin T Shearn

JPEN J Parenter Enteral Nutr· July 2022

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Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.
Karim C El Kasmi, Swati Ghosh, Aimee L Anderson, Michael W Devereaux, Natarajan Balasubramaniyan, Colin T Shearn

Hepatology· February 2022

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NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.
Swati Ghosh, Michael W Devereaux, Aimee L Anderson, Sarah Gehrke, Julie A Reisz, Colin T Shearn

Hepatology· December 2021

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Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach.
Georgia Charkoftaki, Jaya Prakash Golla, Alvaro Santos-Neto, David J Orlicky, Rolando Garcia-Milian, Colin T Shearn

Toxicol Sci· September 2021

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Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.
Aml A Alnaas, Abena Watson-Siriboe, Sherleen Tran, Mikias Negussie, Jack A Henderson, Colin T Shearn

J Biol Chem· August 2021

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Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis.
Rachel Y Gao, Colin T Shearn, David J Orlicky, Kayla D Battista, Erica E Alexeev

Mucosal Immunol· March 2021

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Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption.
Colin G Miller, Jean A Kundert, Justin R Prigge, Julie A Amato, Allison E Perez, Colin T Shearn

Antioxidants (Basel)· February 2021

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4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.
Guodong Pan, Mandar Deshpande, Haiyan Pang, Paul M Stemmer, Nicholas J Carruthers, Colin T Shearn

J Cell Biochem· December 2020

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Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.
Colin T Shearn, Blair Fennimore, David J Orlicky, Yue R Gao, Laura M Saba

Free Radic Biol Med· November 2019

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TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Michael R McLoughlin, David J Orlicky, Justin R Prigge, Pushya Krishna, Emily A Talago, Colin T Shearn

Proc Natl Acad Sci U S A· June 2019

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Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.
Hadi R Ali, Mohammed A Assiri, Peter S Harris, Cole R Michel, Youngho Yun, Colin T Shearn

J Proteome Res· April 2019

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Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
Hadi Ali, Mohammed A Assiri, Colin T Shearn, Kristofer S Fritz

Curr Opin Toxicol· February 2019

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Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.
Dennis R Petersen, Laura M Saba, Volkan I Sayin, Thales Papagiannakopoulos, Edward E Schmidt, Colin T Shearn

PLoS One· November 2018

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Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Dennis R Petersen, David J Orlicky, James R Roede, Colin T Shearn

Exp Mol Pathol· August 2018

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Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.
Colin T Shearn, Casey F Pulliam, Kim Pedersen, Kyle Meredith, Kelly E Mercer

Alcohol Clin Exp Res· July 2018

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Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.
Kusum K Kharbanda, Martin J J Ronis, Colin T Shearn, Dennis R Petersen, Samir Zakhari

Biomolecules· March 2018

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