Publications by authors named "Conghao Gai"

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Design, Synthesis and Anticancer Activity of 6-Substituted-1-(3,4,5-trimethoxyphenyl)--indole Against Tubulin Polymerisation.
Yuanna Gu, Conghao Gai, Sijie Zou, Yan Song, Juan Zhang

Molecules· November 2025

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Optimization of antimicrobial peptide Smp43 as novel inhibitors of Cancer.
Zhou Yu, Dan Han, Kai Zhang, Conghao Gai, Xiaoyun Chai

Bioorg Chem· July 2025

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Discovery of novel N-(5-chloro-2,4-dimethoxyphenyl)-N-heterocyclic ketone analogs as potent anti-inflammatory agents against ulcerative colitis.
Juan Zhang, Boye Jiang, Xiaoqing Yun, Conghao Gai, Zhen Wang

Bioorg Chem· July 2025

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Design, synthesis, and antitumor activity of stapled peptide inhibitors targeting the RAS-RAF interactions.
Dan Han, Zhou Yu, Kai Zhang, Conghao Gai, Peichao Zhang

Eur J Med Chem· June 2025

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Carbamothioate-mediated Selectfluor™ oxidation for the synthesis of benzenesulfonyl fluorides in chalcone derivatives.
Boye Jiang, Juan Zhang, Boning Wang, Airui Zhou, Yan Zou, Conghao Gai

RSC Adv· June 2025

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Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS-mutant cancer models.
Shihui Shen, Qiansen Zhang, Yuhan Wang, Hui Chen, Shuangming Gong, Conghao Gai

J Clin Invest· March 2025

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Comprehensive exploration of isocitrate dehydrogenase (IDH) mutations: Tumorigenesis, drug discovery, and covalent inhibitor advances.
Conghao Gai, Hairong Zeng, Haoming Xu, Xiaoyun Chai, Yan Zou

Eur J Med Chem· January 2025

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The study of halogen effect on the reactivity of the serine-targeting covalent warheads.
Conghao Gai, Ya Zhang, Shihao Zhang, Xueyan Hu, Yun-Qing Song

Front Chem· December 2024

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Correction: Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents.
Zhen Wang, Juan Zhang, Conghao Gai, Jing Wang, Xiaobin Zhuo

RSC Med Chem· July 2024

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Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents.
Zhen Wang, Juan Zhang, Conghao Gai, Jing Wang, Xiaobin Zhuo

RSC Med Chem· June 2024

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Total synthesis and structural modification of the dibenzylbutane lignan LCA as a potent anti-inflammatory agent against LPS-induced acute lung injury.
Juan Zhang, Zhen Wang, Jing Wang, Xiaobin Zhuo, Luyao Yu, Conghao Gai

Eur J Med Chem· March 2024

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Cyclic Peptide Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Design, Synthesis, and In Vivo Treatment of Acute Lung Injury.
Jihua Zou, Jianyu Yan, Yifei Lu, Zhou Yu, Kai Zhang, Conghao Gai

J Med Chem· March 2024

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Further structural optimization and SAR study of sungsanpin derivatives as cell-invasion inhibitors.
Shuai Chen, Kai Zhang, Jihua Zou, Zhou Yu, Conghao Gai

Bioorg Med Chem Lett· February 2024

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Design, synthesis, evaluation and optimization of novel azole analogues as potent antifungal agents.
Juan Zhang, Zhen Wang, Conghao Gai, Fan Yang, Xiaoqing Yun

Bioorg Med Chem· January 2024

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SOS1-inspired hydrocarbon-stapled peptide as a pan-Ras inhibitor.
Anpeng Li, Xiang Li, Jihua Zou, Xiaobin Zhuo, Shuai Chen, Conghao Gai

Bioorg Chem· June 2023

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Rational Optimizations of the Marine-Derived Peptide Sungsanpin as Novel Inhibitors of Cell Invasion.
Anpeng Li, Jihua Zou, Xiaobin Zhuo, Shuai Chen, Xiaoyun Chai, Conghao Gai

Chem Biodivers· February 2023

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Advanced approaches of developing targeted covalent drugs.
Conghao Gai, Suzannah J Harnor, Shihao Zhang, Céline Cano, Chunlin Zhuang

RSC Med Chem· December 2022

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Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid.
Mélanie Uguen, Conghao Gai, Lukas J Sprenger, Hang Liu, Andrew G Leach

RSC Adv· September 2021

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FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
Daniel J Wood, J Daniel Lopez-Fernandez, Leanne E Knight, Islam Al-Khawaldeh, Conghao Gai

J Med Chem· April 2019

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