Publications by authors named "Conor Gruber"

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Monoallelic expression can govern penetrance of inborn errors of immunity.
O'Jay Stewart, Conor Gruber, Haley E Randolph, Roosheel Patel, Meredith Ramba

Nature· January 2025

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Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.
Masato Ogishi, Koji Kitaoka, Kim L Good-Jacobson, Darawan Rinchai, Baihao Zhang, Conor Gruber

Immunity· December 2024

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Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis.
Michael E Horesh, Marta Martin-Fernandez, Conor Gruber, Sofija Buta, Tom Le Voyer

J Exp Med· June 2024

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Correction: Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis.
Michael E Horesh, Marta Martin-Fernandez, Conor Gruber, Sofija Buta, Tom Le Voyer

J Exp Med· June 2024

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IL4Rα and IL17A Blockade Rescue Autoinflammation in SOCS1 Haploinsufficiency.
Conor Gruber, Angelica Lee, Sofija Buta, Saakshi Khattri, Alice B Gottlieb

J Clin Immunol· December 2023

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Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C).
Conor N Gruber, Roosheel S Patel, Rebecca Trachtman, Lauren Lepow, Fatima Amanat

Cell· July 2023

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Acquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids.
Fredrik I Thege, Ian I Cardle, Conor N Gruber, Megan J Siemann, Sophie Cong

PLoS One· May 2022

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A partial form of inherited human USP18 deficiency underlies infection and inflammation.
Marta Martin-Fernandez, Sofija Buta, Tom Le Voyer, Zhi Li, Lasse Toftdal Dynesen, Conor Gruber

J Exp Med· April 2022

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ISG15 deficiency restricts HIV-1 infection.
Denise Jurczyszak, Lara Manganaro, Sofija Buta, Conor Gruber, Marta Martin-Fernandez

PLoS Pathog· March 2022

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Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.
Masato Ogishi, Rui Yang, Caner Aytekin, David Langlais, Mathieu Bourgey, Conor Gruber

Nat Med· September 2021

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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.
Justin Taft, Michael Markson, Diana Legarda, Roosheel Patel, Mark Chan, Conor Gruber

Cell· August 2021

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Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease.
Tom Le Voyer, Anna-Lena Neehus, Rui Yang, Masato Ogishi, Jérémie Rosain, Conor Gruber

Proc Natl Acad Sci U S A· April 2021

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Multibatch Cytometry Data Integration for Optimal Immunophenotyping.
Masato Ogishi, Rui Yang, Conor Gruber, Peng Zhang, Simon J Pelham

J Immunol· January 2021

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Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria.
Rui Yang, Federico Mele, Lisa Worley, David Langlais, Jérémie Rosain, Conor Gruber

Cell· December 2020

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Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C).
Conor N Gruber, Roosheel S Patel, Rebecca Trachtman, Lauren Lepow, Fatima Amanat

Cell· November 2020

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Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function.
Conor N Gruber, Jorg J A Calis, Sofija Buta, Gilad Evrony, Jerome C Martin

Immunity· September 2020

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Type I IFN is siloed in endosomes.
Jennie B Altman, Justin Taft, Tim Wedeking, Conor N Gruber, Michael Holtmannspötter

Proc Natl Acad Sci U S A· July 2020

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Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C).
Conor Gruber, Roosheel Patel, Rebecca Trachman, Lauren Lepow, Fatima Amanat

medRxiv· July 2020

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Incomplete penetrance in primary immunodeficiency: a skeleton in the closet.
Conor Gruber, Dusan Bogunovic

Hum Genet· June 2020

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Impaired interferon signature in severe COVID-19.
Conor Gruber

Nat Rev Immunol· June 2020

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Immunology of COVID-19: Current State of the Science.
Nicolas Vabret, Graham J Britton, Conor Gruber, Samarth Hegde, Joel Kim

Immunity· June 2020

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Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy.
Conor Gruber, Marta Martin-Fernandez, Fatima Ailal, Xueer Qiu, Justin Taft

J Exp Med· May 2020

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Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions.
Marta Martin-Fernandez, María Bravo García-Morato, Conor Gruber, Sara Murias Loza, Muhammad Nasir Hayat Malik

Cell Rep· May 2020

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JAK Inhibitor Therapy in a Child with Inherited USP18 Deficiency.
Fahad Alsohime, Marta Martin-Fernandez, Mohamad-Hani Temsah, Majed Alabdulhafid, Tom Le Voyer, Conor Gruber

N Engl J Med· January 2020

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anti-EGFR capture mitigates EMT- and chemoresistance-associated heterogeneity in a resistance-profiling CTC platform.
Fredrik I Thege, Conor N Gruber, Ian I Cardle, Sophie H Cong, Timothy B Lannin

Anal Biochem· July 2019

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