Publications by authors named "Conrad Chan"

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Radiopharmaceutical kit to prepare Copper-64 labelled porphyrin-lipid nanoparticles for radiotracer imaging studies in cancer patients.
Michael S Valic, Carl J Fisher, Mark Zheng, Alexander M Gregor, Wenlei Jiang, Conrad Chan, Harley H L Chan

Eur J Nucl Med Mol Imaging· December 2025

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Positron Emission Tomography/Computed Tomography (PET/CT) and Radioimmunotherapy of Head and Neck Cancer Patient Derived Xenografts in NRG Mice with Theranostic [Cu]Cu-DOTA-Panitumumab F(ab') and [Lu]Lu-DOTA-Panitumumab F(ab').
Meysam Khosravifarsani, Conrad Chan, Anthony Ku, Noor Alsaden, Jalna Meens

Mol Pharm· November 2025

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Evaluating the effectiveness of international travel controls to identify MPXV-infected travelers: a simulation study.
Keisuke Ejima, Yuqian Wang, Akira Endo, Hiroaki Murayama, Yun Shan Goh, Conrad En Zuo Chan

BMC Med· August 2025

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Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR.
Kui You, Nurhidayah Binte Mohamed Yazid, Li Ming Chong, Lissa Hooi, Peter Wang, Conrad E Z Chan

NPJ Antimicrob Resist· February 2025

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Preclinical Comparison of [In]In- and [Ac]Ac-DOTA-Trastuzumab IgG, F(ab') and Fab for Theranostic SPECT/CT Imaging and α-Particle Radioimmunotherapy of HER2-Positive Human Breast Cancer.
Misaki Kondo, Zhongli Cai, Conrad Chan, Madeline K Brown, Raymond M Reilly

Mol Pharm· January 2025

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Defining the Critical Requisites for Accurate Simulation of SARS-CoV-2 Viral Dynamics: Patient Characteristics and Data Collection Protocol.
Hoong Kai Chua, Ananya Singh, Yuqian Wang, Yun Shan Goh, Conrad En Zuo Chan

J Med Virol· January 2025

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SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with Pb-PSC-panitumumab in NRG mice.
Nasim Sarrami, Bryce Nelson, Samantha Leier, John Wilson, Conrad Chan

EJNMMI Radiopharm Chem· November 2024

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Bidirectional Evolution of SARS-CoV-2 Virus in Immunocompromised Hosts.
Charmaine W Y Chew, Barnaby E Young, Paul A Tambyah, Shawn Vasoo, Conrad E Z Chan

Influenza Other Respir Viruses· March 2024

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Neutralization escape of emerging subvariants XBB.1.5/1.9.1 and XBB.2.3 from current therapeutic monoclonal antibodies.
De Hoe Chye, Charmaine W Y Chew, He Ping Yeo, Paul A Tambyah, Barnaby E Young, Conrad E Z Chan

J Med Virol· September 2023

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Author Correction: An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis.
Shivankari Krishnananthasivam, Hao Li, Rania Bouzeyen, Bhuvaneshwari Shunmuganathan, Kiren Purushotorman, Conrad En Zuo Chan

NPJ Vaccines· September 2023

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[Ac]Ac- and [In]In-DOTA-trastuzumab theranostic pair: cellular dosimetry and cytotoxicity in vitro and tumour and normal tissue uptake in vivo in NRG mice with HER2-positive human breast cancer xenografts.
Misaki Kondo, Zhongli Cai, Conrad Chan, Nubaira Forkan, Raymond M Reilly

EJNMMI Radiopharm Chem· September 2023

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An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis.
Shivankari Krishnananthasivam, Hao Li, Rania Bouzeyen, Bhuvaneshwari Shunmuganathan, Kiren Purushotorman, Conrad En Zuo Chan

NPJ Vaccines· August 2023

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Residual Humoral Immunity Sustained Over Decades in a Cohort of Vaccinia-Vaccinated Individuals.
Conrad E Z Chan, Steven K K Wong, Nurhidayah Binte M Yazid, Oon Tek Ng, Kalisvar Marimuthu, Monica Chan

J Infect Dis· April 2023

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Formulation of a kit under Good Manufacturing Practices (GMP) for preparing [In]In-BnDTPA-trastuzumab-NLS injection: a theranostic agent for imaging and Meitner-Auger Electron (MAE) radioimmunotherapy of HER2-positive breast cancer.
Conrad Chan, Vanessa Prozzo, Sadaf Aghevlian, Raymond M Reilly

EJNMMI Radiopharm Chem· December 2022

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Y-Labeled Gold Nanoparticle Depot (NPD) Combined with Anti-PD-L1 Antibodies Strongly Inhibits the Growth of 4T1 Tumors in Immunocompetent Mice and Induces an Abscopal Effect on a Distant Non-Irradiated Tumor.
Zhongli Cai, Rella Liu, Conrad Chan, Yijie Lu, Mitchell A Winnik

Mol Pharm· November 2022

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First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults.
Venkateshan S Prativadibhayankaram, Lawrence Soon-U Lee, David Lye, Xu Xiaoying, Ranjani Nellore, Conrad E Z Chan

Infect Dis Ther· October 2022

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Defining the specificity and function of a human neutralizing antibody for Hepatitis B virus.
Saket Jhajharia, Fritz Lai, Heng Boon Low, Kiren Purushotorman, Bhuvaneshwari D/O Shunmuganathan, Conrad En Zuo Chan

NPJ Vaccines· October 2022

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IDentif.AI-Omicron: Harnessing an AI-Derived and Disease-Agnostic Platform to Pinpoint Combinatorial Therapies for Clinically Actionable Anti-SARS-CoV-2 Intervention.
Agata Blasiak, Anh T L Truong, Peter Wang, Lissa Hooi, De Hoe Chye, Conrad E Z Chan

ACS Nano· September 2022

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The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies.
Conrad En-Zuo Chan, Ching-Ging Ng, Angeline Pei-Chew Lim, Shirley Lay-Kheng Seah, De-Hoe Chye

J Virol· July 2022

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The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens.
Agata Blasiak, Anh T L Truong, Alexandria Remus, Lissa Hooi, Shirley Gek Kheng Seah, Conrad En Zuo Chan

NPJ Digit Med· June 2022

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Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson's disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial.
Sam Chun Sum Yuen, Ka Kit Chua, Linda L D Zhong, Kam Wa Chan, Conrad Kwan Ho Chan, Kam Leung Chan

Chin Med· January 2022

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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody.
Conrad E Z Chan, Shirley G K Seah, De Hoe Chye, Shane Massey, Maricela Torres

PLoS One· July 2021

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Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Daniel Asarnow, Bei Wang, Wen-Hsin Lee, Yuanyu Hu, Ching-Wen Huang, Conrad En Zuo Chan

Cell· June 2021

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IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development.
Agata Blasiak, Jhin Jieh Lim, Shirley Gek Kheng Seah, Theodore Kee, Alexandria Remus, Conrad E Z Chan

Bioeng Transl Med· January 2021

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The pharmaceutical stability of trastuzumab after short-term storage at room temperature assessed by analytical techniques and tumour imaging by microSPECT/CT.
Conrad Chan, Jack T Seki, R Kwong, Raymond M Reilly

Int J Pharm· October 2020

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