Publications by authors named "Constance A Mitchell"

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The OASIS Consortium: integrating multi-omics technologies to transform chemical safety assessment.
David Rouquié, Andreas Bender, Jaime Cheah, Christine E Crute, Deidre Dalmas, Constance A Mitchell

Toxicol Sci· December 2025

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TGx-DDI (toxicogenomic DNA damage-inducing) biomarker validation: multi-site ring trial supporting regulatory use.
Xiaotong Wang, Christine E Crute, Ashley Allemang, Jiri Aubrecht, Florence Burleson, Constance A Mitchell

Toxicol Sci· December 2025

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Dose-response assessment of neuroactive botanical extracts and their bioactive constituents using microelectrode array (MEA) recordings in rat primary cortical cultures.
Regina G D M van Kleef, J Pepijn Wopken, Julie Krzykwa, Constance A Mitchell, Remco H S Westerink

Pharm Biol· December 2025

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From Vision to Reality: Five Years of the Botanical Safety Consortium.
Constance A Mitchell, Amy L Roe, Scott Auerbach, Cécile Bascoul, Michelle Embry

Pharm Biol· December 2025

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An exploratory evaluation of the interaction risk between herbal products and pharmaceutical medicines used concurrently for disease management in Blantyre, Malawi.
Kumbukani K Nyirenda, John Mponda, Ibrahim Chikowe, Esther Kawonga, Nellie Twatasha Gomani Phiri, Constance A Mitchell

Pharm Biol· December 2025

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Navigating complexity in modern toxicology: the role of omics in short-term in vivo studies.
Constance A Mitchell, Leah Wehmas, David Rouquié, Florian Caiment, Richard A Currie

Toxicol Sci· November 2025

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Developing an approach for evaluating the cardiotoxic potential of botanicals.
Julie Krzykwa, Hemantkumar S Chaudhari, Andre Monteiro Da Rocha, Matthias Gossmann, Peter Hoffmann, Constance A Mitchell

Front Toxicol· November 2025

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A multi-detector analytical approach for characterizing complex botanical extracts: a case study on ashwagandha.
Vincent P Sica, Constance A Mitchell, Julie Krzykwa, Timothy R Baker, Suramya Waidyanatha

Anal Bioanal Chem· September 2025

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Evaluation of in vivo fish and amphibian endocrine test guideline assays: current status and future needs.
Natalie Burden, Constance A Mitchell, Zhichao Dang, Michelle R Embry, Scott Glaberman

Environ Toxicol Chem· June 2025

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Control performance of Amphibian Metamorphosis Assays with Xenopus laevis.
James R Wheeler, Raechel Puglisi, Adriana C Bejarano, Zhenglei Gao, Laurent Lagadic, Constance A Mitchell

Regul Toxicol Pharmacol· March 2025

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A proposed screening strategy for evaluating the genotoxicity potential of botanicals and botanical extracts.
Kristine L Witt, Jan van Benthem, Tetyana Kobets, Guosheng Chen, Olaf Kelber, Constance A Mitchell

Food Chem Toxicol· March 2025

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Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals.
Amy L Roe, Julie Krzykwa, Angela I Calderón, Cécile Bascoul, Bill J Gurley, Constance A Mitchell

J Diet Suppl· December 2024

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Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium.
Igor Koturbash, R Philip Yeager, Constance A Mitchell, Stephen Ferguson, Victor J Navarro

Regul Toxicol Pharmacol· November 2024

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Prediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models.
Yitong Liu, Michael Lawless, Miao Li, Kiara Fairman, Michelle R Embry, Constance A Mitchell

J Appl Toxicol· August 2024

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Urinary MicroRNA biomarkers of nephrotoxicity in Macaca fascicularis.
Subham Dasgupta, Tatiana Sharapova, Prathap K Mahalingaiah, Brian N Chorley, Ahmed Shoieb, Constance A Mitchell

Regul Toxicol Pharmacol· August 2024

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Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety.
Jyotshna Kanungo, Barbara C Sorkin, Julie Krzykwa, Constance A Mitchell, Michelle Embry

Expert Opin Drug Metab Toxicol· July 2024

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Within-laboratory reproducibility of Ames test results: Are repeat tests necessary?
Errol Zeiger, Constance A Mitchell, Stefan Pfuhler, Yang Liao, Kristine L Witt

Environ Mol Mutagen· May 2024

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Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools.
Suramya Waidyanatha, Bradley J Collins, Tim Cristy, Michelle Embry, Stefan Gafner, Constance A Mitchell

Food Chem Toxicol· April 2024

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Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings.
Regina G D M van Kleef, Michelle R Embry, Constance A Mitchell, Remco H S Westerink

Food Chem Toxicol· February 2024

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Improving the rigor and utility of botanical toxicity studies: Recommended resources.
Deval Patel, Barbara C Sorkin, Constance A Mitchell, Michelle R Embry, Sharline Rina-Kong

Regul Toxicol Pharmacol· October 2023

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New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians.
Constance A Mitchell, Natalie Burden, Mark Bonnell, Markus Hecker, Thomas H Hutchinson

Environ Toxicol Chem· April 2023

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Plant vs. Kidney: Evaluating Nephrotoxicity of Botanicals with the Latest Toxicological Tools.
Adam Pearson, Stefan Gafner, Cynthia V Rider, Michelle Embry, Stephen S Ferguson, Constance A Mitchell

Curr Opin Toxicol· December 2022

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Targeted protein degraders: a call for collective action to advance safety assessment.
Lyn H Jones, Constance A Mitchell, Lise Loberg, Mira Pavkovic, Mohan Rao

Nat Rev Drug Discov· June 2022

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A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.
J Christopher Corton, Constance A Mitchell, Scott Auerbach, Pierre Bushel, Heidrun Ellinger-Ziegelbauer

Toxicol Sci· June 2022

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An international, interlaboratory ring trial confirms the feasibility of an extraction-less "direct" RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples.
Margaret G Mills, Emily Bruce, Meei-Li Huang, Jessica W Crothers, Ollivier Hyrien, Constance A Mitchell

PLoS One· January 2022

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