Publications by authors named "Constance Cullen"

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Pharmacokinetics and pharmacodynamics of Abelacimab (MAA868), a novel dual inhibitor of Factor XI and Factor XIa.
B Alexander Yi, Debra Freedholm, Nancy Widener, Xiaohui Wang, Emilie Simard, Constance Cullen

J Thromb Haemost· February 2022

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Biophysical and Immunological Characterization and Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab.
Beth Hutchins, Gary C Starling, Mark A McCoy, Danuta Herzyk, Frederique M Poulet, Constance Cullen

Mol Cancer Ther· June 2020

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A direct droplet digital PCR method for quantification of residual DNA in protein drugs produced in yeast cells.
Musaddeq Hussain, Rebecca Fantuzzo, Suzanne Mercorelli, Constance Cullen

J Pharm Biomed Anal· May 2016

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Phase I trial of intravesical recombinant adenovirus mediated interferon-α2b formulated in Syn3 for Bacillus Calmette-Guérin failures in nonmuscle invasive bladder cancer.
Colin P N Dinney, Mark B Fisher, Neema Navai, Michael A O'Donnell, David Cutler, Constance Cullen

J Urol· September 2013

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Challenges of developing and validating immunogenicity assays to support comparability studies for biosimilar drug development.
Xiao-Yan Cai, Jeff Thomas, Constance Cullen, Dominique Gouty

Bioanalysis· September 2012

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Recommendations and requirements for the design of bioanalytical testing used in comparability studies for biosimilar drug development.
Xiao-Yan Cai, Dominique Gouty, Sharon Baughman, Ms Ramakrishnan, Constance Cullen

Bioanalysis· March 2011

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Identification of HCV protease inhibitor resistance mutations by selection pressure-based method.
Ping Qiu, Vincent Sanfiorenzo, Stephanie Curry, Zhuyan Guo, Shaotang Liu, Constance Cullen

Nucleic Acids Res· June 2009

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SCH 412499: biodistribution and safety of an adenovirus containing P21(WAF-1/CIP-1) following subconjunctival injection in Cynomolgus monkeys.
Robert W Veneziale, Christopher M Bral, Dinesh P Sinha, Robert W Watkins, Mark E Cartwright, Constance Cullen

Cutan Ocul Toxicol· August 2007

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Pharmacodynamics of PEG-IFN alpha differentiate HIV/HCV coinfected sustained virological responders from nonresponders.
Andrew H Talal, Ruy M Ribeiro, Kimberly A Powers, Michael Grace, Constance Cullen

Hepatology· May 2006

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Biological characterization of pegylated interferons: a case study.
Lei Xie, Constance Cullen, Sheri Bradshaw, Marc DeLorenzo, Michael J Grace

Methods Mol Biol· September 2005

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Site of pegylation and polyethylene glycol molecule size attenuate interferon-alpha antiviral and antiproliferative activities through the JAK/STAT signaling pathway.
Michael J Grace, Seoju Lee, Sheri Bradshaw, Jeffrey Chapman, Jeffrey Spond, Constance Cullen

J Biol Chem· February 2005

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Development and validation of a kinetic assay for analysis of anti-human interleukin-5 monoclonal antibody (SCH 55700) and human interleukin-5 interactions using surface plasmon resonance.
Ruth A DiGiacomo, Lei Xie, Constance Cullen, Stephen R Indelicato

Anal Biochem· April 2004

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Development of a biosensor-based method for detection and isotyping of antibody responses to adenoviral-based gene therapy vectors.
Leslie W Abad, Meredith Neumann, Lori Tobias, Linda Obenauer-Kutner, Sheila Jacobs, Constance Cullen

Anal Biochem· November 2002

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The use of field emission scanning electron microscopy to assess recombinant adenovirus stability.
Linda J Obenauer-Kutner, Peter M Ihnat, Tong-Yuan Yang, Barbara J Dovey-Hartman, Arthi Balu, Constance Cullen

Hum Gene Ther· September 2002

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A single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hyporesponsiveness.
Li Zuo, Constance M Cullen, Monica L DeLay, Sherry Thornton, Linda K Myers

J Immunol· March 2002

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