Publications by authors named "Constance Lay-Lay Saw"

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Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin.
Ximena Paredes-Gonzalez, Francisco Fuentes, Sundrina Jeffery, Constance Lay-Lay Saw, Limin Shu

Biopharm Drug Dispos· October 2015

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Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin.
Sarandeep S S Boyanapalli, Ximena Paredes-Gonzalez, Francisco Fuentes, Chengyue Zhang, Yue Guo, Constance Lay Lay Saw

Chem Res Toxicol· December 2014

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The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.
Constance Lay Lay Saw, Yue Guo, Anne Yuqing Yang, Ximena Paredes-Gonzalez, Christina Ramirez

Food Chem Toxicol· October 2014

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Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid.
Melody A Furnari, Constance Lay-Lay Saw, Ah-Ng Kong, George C Wagner

Brain Res Bull· October 2014

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Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages.
Constance Lay Lay Saw, Anne Yuqing Yang, Mou-Tuan Huang, Yue Liu, Jong Hun Lee

Cell Biosci· September 2014

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Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway.
Constance Lay Lay Saw, Anne Yuqing Yang, Yue Guo, Ah-Ng Tony Kong

Food Chem Toxicol· December 2013

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Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation.
Constance Lay Lay Saw, Qing Wu, Zheng-Yuan Su, Hu Wang, Yinhua Yang

Biopharm Drug Dispos· September 2013

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Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia.
Amanda K Smolarek, Jae Young So, Paul E Thomas, Hong Jin Lee, Shiby Paul, Constance Lay-Lay Saw

Mol Carcinog· July 2013

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Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.
Tien-Yuan Wu, Tin Oo Khor, Zheng-Yuan Su, Constance Lay-Lay Saw, Limin Shu

AAPS J· July 2013

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Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.
Zheng-Yuan Su, Tin Oo Khor, Limin Shu, Jong Hun Lee, Constance Lay-Lay Saw

Chem Res Toxicol· March 2013

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In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways.
Tien-Yuan Wu, Constance Lay-Lay Saw, Tin Oo Khor, Douglas Pung, Sarandeep S S Boyanapalli

Mol Carcinog· October 2012

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Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.
Hu Wang, Tin Oo Khor, Qian Yang, Ying Huang, Tien-Yuan Wu, Constance Lay-Lay Saw

Mol Pharm· October 2012

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Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet.
Constance Lay Lay Saw, Tien-Yuan Wu, Ximena Paredes-Gonzalez, Tin Oo Khor, Douglas Pung

Asian Pac J Cancer Prev· August 2012

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Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations.
Constance Lay Lay Saw, Anne Yuqing Yang, David C Cheng, Sarandeep S-S Boyanapalli, Zheng-Yuan Su

Chem Res Toxicol· August 2012

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A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation.
Ying Huang, Tin Oo Khor, Limin Shu, Constance Lay-Lay Saw, Tien-Yuan Wu

J Nutr· May 2012

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Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.
Constance Lay-Lay Saw, Melvilí Cintrón, Tien-Yuan Wu, Yue Guo, Ying Huang

Biopharm Drug Dispos· July 2011

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Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis.
Tien-Yuan Wu, Tin Oo Khor, Constance Lay Lay Saw, Stephanie C Loh, Alvin I Chen

AAPS J· March 2011

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Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer.
Constance Lay Lay Saw, Ah-Ng Tony Kong

Expert Opin Ther Targets· March 2011

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Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory.
Rong Hu, Constance Lay-Lay Saw, Rong Yu, Ah-Ng Tony Kong

Antioxid Redox Signal· December 2010

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Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid.
Hu Wang, Tin Oo Khor, Constance Lay Lay Saw, Wen Lin, Tienyuan Wu

Mol Pharm· December 2010

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Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.
Constance Lay-Lay Saw, Qing Wu, Ah-Ng Tony Kong

Chin Med· October 2010

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Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid.
Constance Lay Lay Saw, Ying Huang, Ah-Ng Kong

Biochem Pharmacol· February 2010

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Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats.
Avantika Barve, Chi Chen, Vidya Hebbar, Joseph Desiderio, Constance Lay-Lay Saw

Biopharm Drug Dispos· October 2009

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Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling.
Auemduan Prawan, Constance Lay Lay Saw, Tin Oo Khor, Young-Sam Keum, Siwang Yu

Chem Biol Interact· May 2009

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Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques.
Jun Liu, Constance Lay Lay Saw, Malini Olivo, Thankiah Sudhaharan, Sohail Ahmed

J Biomed Opt· April 2009

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