Publications by authors named "Corey Hopkins"

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Synthesis and Biological Characterization of 4,4-Difluoro-3-(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (DR) Antagonist in vitro Tool compounds.
Saeedeh Saeedi, Sumaiya Nahid, Anish K Vadukoot, Corey R Hopkins

ChemMedChem· August 2025

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Further Structure-Activity Relationship of G Protein-Gated Inwardly Rectifying Potassium Channels 1/2 Activators: Synthesis and Biological Characterization of In Vitro Tool Compounds.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany D Spitznagel, Sandeep K Singh, Corey R Hopkins

ChemMedChem· July 2025

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Update on mGlu4 modulator patents: 2017 to present.
Fahad Imtiaz Rahman, Thomas M Webster, Corey R Hopkins

Expert Opin Ther Pat· May 2025

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End-to-End Backbone Cyclization Enhances Passive Permeability of bRo5 Oligomeric Depsipeptides with Nonlinear Size Dependence.
Madelaine P Thorpe, Corey R Hopkins, Jeffrey N Johnston

ACS Med Chem Lett· April 2025

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Phosphodiesterase 4 (PDE4) and neurological disorders: A promising frontier in neuropharmacology.
Sumaiya Nahid, Saeedeh Saeedi, Corey R Hopkins

Adv Pharmacol· February 2025

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Discovery of VU0467319: an M Positive Allosteric Modulator Candidate That Advanced into Clinical Trials.
Michael S Poslunsey, Michael R Wood, Changho Han, Shaun R Stauffer, Joseph D Panarese, Corey R Hopkins

ACS Chem Neurosci· January 2025

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The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by -verticilide.
Madelaine P Thorpe, Abigail N Smith, Daniel J Blackwell, Corey R Hopkins, Bjorn C Knollmann

Chem Sci· August 2024

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Use of ECT in Autism Spectrum Disorder and/or Intellectual Disability: A Single Site Retrospective Analysis.
Joshua R Smith, Corey E Hopkins, Jiangmei Xiong, James Luccarelli, Elizabeth Shultz

J Autism Dev Disord· March 2024

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Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1.
Viktoriya Mashinson, Thomas M Webster, Anish K Vadukoot, Kirsten T Tolentino, Princess Simeon, Corey R Hopkins

Bioorg Med Chem· September 2023

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In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule -Verticilide.
Daniel J Blackwell, Abigail N Smith, Tri Do, Aaron Gochman, Jeffrey Schmeckpeper, Corey R Hopkins

J Pharmacol Exp Ther· June 2023

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Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis.
Iram Fatima, Jaya Prakash Uppada, Yashpal S Chhonker, Saiprasad Gowrikumar, Susmita Barman, Corey R Hopkins

Biomed Pharmacother· March 2023

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From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of σ1 modulators.
Kirsten T Tolentino, Viktoriya Mashinson, Manish K Sharma, Yashpal S Chhonker, Daryl J Murry, Corey R Hopkins

Eur J Med Chem· December 2022

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Structure-Activity Relationships for the -Me- Versus -H-Amide Modification to Macrocyclic -Verticilide Antiarrhythmics.
Abigail N Smith, Madelaine P Thorpe, Daniel J Blackwell, Suzanne M Batiste, Corey R Hopkins

ACS Med Chem Lett· November 2022

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Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1-Alkyl-2-(pyrrolidin-1-yl)-1H-benzo[d]imidazoles as Potent and Selective Inhibitors.
Swagat Sharma, Juan L Pablo, Kirsten T Tolentino, Wacey Gallegos, Jennifer Hinman, Corey R Hopkins

ChemMedChem· July 2022

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Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1.
Swagat Sharma, Qi Peng, Anish K Vadukoot, Christopher D Aretz, Aaron A Jensen, Corey R Hopkins

ACS Med Chem Lett· May 2022

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Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists.
Kirsten T Tolentino, Viktoriya Mashinson, Anish K Vadukoot, Corey R Hopkins

Bioorg Med Chem Lett· April 2022

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Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein-Gated Inwardly Rectifying K Channels.
Allison Anderson, Baovi N Vo, Ezequiel Marron Fernandez de Velasco, Corey R Hopkins, C David Weaver

Mol Pharmacol· December 2021

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Virtual screening and biological evaluation of PPARγ antagonists as potential anti-prostate cancer agents.
Suliman Almahmoud, Catherine C Elix, Jeremy O Jones, Corey R Hopkins, Jonathan L Vennerstrom

Bioorg Med Chem· September 2021

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TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models.
Yiming Zhou, Choah Kim, Juan Lorenzo B Pablo, Fan Zhang, Ji Yong Jung, Corey R Hopkins

Front Med (Lausanne)· September 2021

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Discovery, synthesis and biological characterization of a series of -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators.
Swagat Sharma, Lauren Lesiak, Christopher D Aretz, Yu Du, Sushil Kumar, Corey R Hopkins

RSC Med Chem· August 2021

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Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior.
Baovi N Vo, Ezequiel Marron Fernandez de Velasco, Timothy R Rose, Hannah Oberle, Haichang Luo, Corey R Hopkins

J Neurosci· July 2021

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PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells.
Balawant Kumar, Rizwan Ahmad, Swagat Sharma, Saiprasad Gowrikumar, Mark Primeaux, Corey R Hopkins

Cancers (Basel)· April 2021

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Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides.
Christopher D Aretz, Sujay V Kharade, Keagan Chronister, Renata Rusconi Trigueros, Erick J Martinez Rodriguez, Corey R Hopkins

ChemMedChem· January 2021

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Synthesis and SAR Studies of 1-Pyrrolo[2,3-]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors.
Anish K Vadukoot, Swagat Sharma, Christopher D Aretz, Sushil Kumar, Nagsen Gautam, Corey R Hopkins

ACS Med Chem Lett· October 2020

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Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors.
Darren W Engers, Sean R Bollinger, Andrew S Felts, Anish K Vadukoot, Charles H Williams, Corey R Hopkins

Bioorg Med Chem Lett· September 2020

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