Publications by authors named "Cory Stiff"

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Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Todd W Butler, Cory M Stiff

J Med Chem· June 2024

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Protocol for the Direct Conversion of Lactones to Lactams Mediated by 1,5,7-Triazabicyclo[4.4.0]dec-5-ene: Synthesis of Pyridopyrazine-1,6-diones.
Danica A Rankic, Cory M Stiff, Christopher W Am Ende, John M Humphrey

J Org Chem· December 2017

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Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Martin Pettersson, Douglas S Johnson, Danica A Rankic, Gregory W Kauffman, Christopher W Am Ende, Cory M Stiff

Medchemcomm· April 2017

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Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Todd W Butler, Christopher W Am Ende, Cory M Stiff

ACS Med Chem Lett· May 2015

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Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Edelweiss Evrard, Cory M Stiff

Bioorg Med Chem Lett· February 2015

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Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators.
Martin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, Kelly R Bales, Christopher W am Ende, Cory M Stiff

J Med Chem· February 2014

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O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors.
Micah J Niphakis, Douglas S Johnson, T Eric Ballard, Cory Stiff, Benjamin F Cravatt

ACS Chem Neurosci· May 2012

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Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.
Martin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, Kelly R Bales, Christopher W am Ende, Cory M Stiff

Bioorg Med Chem Lett· April 2012

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Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.
Christina J Crump, Benjamin A Fish, Suita V Castro, De-Ming Chau, Natalya Gertsik, Cory Stiff

ACS Chem Neurosci· December 2011

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Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
Kay Ahn, Sarah E Smith, Marya B Liimatta, David Beidler, Nalini Sadagopan, Cory Stiff

J Pharmacol Exp Ther· July 2011

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Novel γ-secretase modulators: a review of patents from 2008 to 2010.
Martin Pettersson, Gregory W Kauffman, Christopher W am Ende, Nandini C Patel, Cory Stiff

Expert Opin Ther Pat· February 2011

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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
Douglas S Johnson, Cory Stiff, Scott E Lazerwith, Suzanne R Kesten, Lorraine K Fay

ACS Med Chem Lett· February 2011

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Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Douglas S Johnson, Kay Ahn, Suzanne Kesten, Scott E Lazerwith, Yuntao Song, Cory Stiff

Bioorg Med Chem Lett· May 2009

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Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Kay Ahn, Douglas S Johnson, Mauro Mileni, David Beidler, Jonathan Z Long, Cory Stiff

Chem Biol· April 2009

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Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics.
Cory Stiff, David R Graber, Atli Thorarensen, Brian D Wakefield, Keith R Marotti

Bioorg Med Chem Lett· December 2008

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Studies on the Bisoxazoline and (-)-Sparteine Mediated Enantioselective Addition of Organolithium Reagents to Imines.
Scott E Denmark, Noriyuki Nakajima, Cory M Stiff, Olivier J-C Nicaise, Michael Kranz

Adv Synth Catal· May 2008

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Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.
Paul V Fish, Christopher Deur, Xinmin Gan, Keri Greene, David Hoople, Cory Stiff

Bioorg Med Chem Lett· April 2008

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Correlation of carboxylic acid pKa to protein binding and antibacterial activity of a novel class of bacterial translation inhibitors.
Cory M Stiff, Min Zhong, Ronald W Sarver, Hua Gao, Andrea M Ho

Bioorg Med Chem Lett· October 2007

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Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles.
Jianke Li, Brian D Wakefield, J Craig Ruble, Cory M Stiff, Donna L Romero

Bioorg Med Chem Lett· April 2007

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