Publications by authors named "Cosimo D Altomare"

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Investigating Amphoteric 3,4'-Biscoumarin-Based -[(Dialkylamino)methyl]phenols as Dual MAO and ChE Inhibitors.
Anthi Petrou, Caterina Deruvo, Rosa Purgatorio, Boris Lichitsky, Andrey N Komogortsev, Cosimo D Altomare

Int J Mol Sci· October 2025

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Bombyx Mori Silk Fibroin as a Sustainable Organocatalyst for Diastereoselective Michael Additions.
Carola Ricciardelli, Giorgio Rizzo, Pietro Cotugno, Antonio Salomone, Daniela Trisciuzzi, Cosimo D Altomare

ChemSusChem· August 2025

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Clinical course and management challenges in Lafora disease: a narrative analysis in an Apulian cohort.
Giuseppe d'Orsi, Maria Teresa Di Claudio, Antonella Liantonio, Paola Imbrici, Cosimo Damiano Altomare

Orphanet J Rare Dis· August 2025

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Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor.
Federica Poggialini, Paolo Governa, Chiara Vagaggini, Samuele Maramai, Stefania Lamponi, Cosimo Damiano Altomare

Eur J Pharm Sci· June 2025

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CUPID: A free drug discovery platform for the explainable multi-ion channel assessment of cardiotoxicity.
Nicola Gambacorta, Fabrizio Mastrolorito, Maria Vittoria Togo, Vincenzo Amenduni, Marco Mele, Cosimo Damiano Altomare

Eur J Med Chem· June 2025

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Empagliflozin Repurposing for Lafora Disease: A Pilot Clinical Trial and Preclinical Investigation of Novel Therapeutic Targets.
Giuseppe d'Orsi, Antonella Liantonio, Paola Imbrici, Nicola Gambacorta, Giorgia Dinoi, Cosimo Damiano Altomare

Methods Protoc· May 2025

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Inflammaging and Immunosenescence in the Post-COVID Era: Small Molecules, Big Challenges.
Fabio Francavilla, Francesca Intranuovo, Gabriella La Spada, Enza Lacivita, Marco Catto, Cosimo Damiano Altomare

ChemMedChem· March 2025

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The potential of MAO inhibitors as chemotherapeutics in cancer: A literature survey.
Sabina Sblano, Angelina Boccarelli, Caterina Deruvo, Gabriella La Spada, Modesto de Candia, Cosimo Damiano Altomare

Eur J Med Chem· February 2025

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Retrospective Clinical Investigation into the Association Between Abnormal Blood Clotting, Oral Anticoagulant Therapy, and Medium-Term Mortality in a Cohort of COVID-19 Patients.
Giorgia Dinoi, Maria Vittoria Togo, Pietro Guida, Caterina Deruvo, Francesco Samarelli, Cosimo Damiano Altomare

Biomedicines· February 2025

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fragSMILES as a chemical string notation for advanced fragment and chirality representation.
Fabrizio Mastrolorito, Fulvio Ciriaco, Maria Vittoria Togo, Nicola Gambacorta, Daniela Trisciuzzi, Cosimo Damiano Altomare

Commun Chem· January 2025

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Advances in synthesis of novel annulated azecines and their unique pharmacological properties.
Anna V Listratova, Francesco Samarelli, Alexander A Titov, Rosa Purgatorio, Modesto de Candia, Cosimo D Altomare

Eur J Med Chem· December 2024

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TIRESIA and TISBE: Explainable Artificial Intelligence Based Web Platforms for the Transparent Assessment of the Developmental Toxicity of Chemicals and Drugs.
Maria Vittoria Togo, Fabrizio Mastrolorito, Nicola Gambacorta, Daniela Trisciuzzi, Anna Rita Tondo, Cosimo Damiano Altomare

Methods Mol Biol· September 2024

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Where developmental toxicity meets explainable artificial intelligence: state-of-the-art and perspectives.
Maria Vittoria Togo, Fabrizio Mastrolorito, Angelica Orfino, Elisabetta Anna Graps, Anna Rita Tondo, Cosimo Damiano Altomare

Expert Opin Drug Metab Toxicol· July 2024

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Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults.
Francesco Samarelli, Rosa Purgatorio, Gianfranco Lopopolo, Caterina Deruvo, Marco Catto, Cosimo D Altomare

Eur J Med Chem· April 2024

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Nature-Inspired 1-Phenylpyrrolo[2,1-]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance.
Alisa A Nevskaya, Rosa Purgatorio, Tatiana N Borisova, Alexey V Varlamov, Lada V Anikina, Cosimo D Altomare

Pharmaceuticals (Basel)· April 2024

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Radiosynthesis and whole-body distribution in mice of a F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease.
Sang Hee Lee, Rosa Purgatorio, Francesco Samarelli, Marco Catto, Nunzio Denora, Cosimo D Altomare

Arch Pharm (Weinheim)· March 2024

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A second life for MAO inhibitors? From CNS diseases to anticancer therapy.
Sabina Sblano, Angelina Boccarelli, Francesco Mesiti, Rosa Purgatorio, Modesto de Candia, Cosimo D Altomare

Eur J Med Chem· March 2024

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Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
Claudia Mugnaini, Antonella Brizzi, Marco Paolino, Enrico Scarselli, Riccardo Castelli, Cosimo D Altomare

ACS Chem Neurosci· March 2024

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Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal.
Francesco Samarelli, Giovanni Graziano, Nicola Gambacorta, Elisabetta Anna Graps, Francesco Leonetti, Cosimo Damiano Altomare

Viruses· March 2024

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TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity.
Fabrizio Mastrolorito, Maria Vittoria Togo, Nicola Gambacorta, Daniela Trisciuzzi, Viviana Giannuzzi, Cosimo Damiano Altomare

Chem Res Toxicol· February 2024

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Sodium-glucose cotransporter-2 inhibitors: A potential novel treatment for Lafora disease?
Paola Imbrici, Giuseppe d'Orsi, Massimo Carella, Orazio Nicolotti, Annamaria De Luca, Cosimo Damiano Altomare

Pharmacol Res· January 2024

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A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics.
Rosa Purgatorio, Angelina Boccarelli, Leonardo Pisani, Modesto de Candia, Marco Catto, Cosimo D Altomare

Antioxidants (Basel)· January 2024

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In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase.
Modesto de Candia, Alexander A Titov, Antonio Viayna, Larisa N Kulikova, Rosa Purgatorio, Cosimo D Altomare

Chem Biol Interact· December 2023

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Making sense of chemical space network shows signs of criticality.
Nicola Amoroso, Nicola Gambacorta, Fabrizio Mastrolorito, Maria Vittoria Togo, Daniela Trisciuzzi, Cosimo Damiano Altomare

Sci Rep· December 2023

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CIRCE: Web-Based Platform for the Prediction of Cannabinoid Receptor Ligands Using Explainable Machine Learning.
Nicola Gambacorta, Fulvio Ciriaco, Nicola Amoroso, Cosimo Damiano Altomare, Jürgen Bajorath

J Chem Inf Model· September 2023

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