Publications by authors named "Cyrus Jin"

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Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes.
Woong Sub Byun, Zhe Zhuang, Anna P Hnatiuk, Cyrus Jin, Zixuan Jiang

J Am Chem Soc· October 2025

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CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer.
Nikola Knoll, Sarah Masser, Blanka Bordas, Richard Y Ebright, Guangyan Li, Cyrus Y Jin

Cancer Res· September 2025

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Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1.
Katrina Warner, Moritz Hunkeler, Kheewoong Baek, Anna Schmoker, Shourya S Roy Burman, Cyrus Jin

Cell Rep· May 2025

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Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5.
Cyrus Y Jin, Moritz Hunkeler, Kathleen M Mulvaney, William R Sellers, Eric S Fischer

J Biol Chem· February 2025

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F-boxing substrates away.
Cyrus Jin, Milka Kostic

Nat Chem Biol· December 2024

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Template-assisted covalent modification underlies activity of covalent molecular glues.
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Cyrus Y Jin

Nat Chem Biol· December 2024

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Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Muhammad Murtaza Hassan, Yen-Der Li, Michelle W Ma, Mingxing Teng, Woong Sub Byun, Cyrus Y Jin

Eur J Med Chem· December 2024

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Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias.
Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Cyrus Jin

Blood· September 2024

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Exploration of the Tunability of BRD4 Degradation by DCAF16 -labelling Covalent Glues.
Muhammad Murtaza Hassan, Yen-Der Li, Michelle W Ma, Mingxing Teng, Woong Sub Byun, Cyrus Y Jin

bioRxiv· October 2023

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HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.
Julie K Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A Donovan, Michelle W Ma, Cyrus Y Jin

Cell Rep· May 2023

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Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Moritz Hunkeler, Cyrus Y Jin, Eric S Fischer

Science· March 2023

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Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Cyrus Y Jin

bioRxiv· February 2023

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Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
Peter G Miller, Murugappan Sathappa, Jamie A Moroco, Wei Jiang, Yue Qian, Cyrus Jin

Nat Commun· June 2022

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Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Moritz Hunkeler, Cyrus Y Jin, Michelle W Ma, Julie K Monda, Daan Overwijn

Mol Cell· September 2021

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Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases.
Kanishk Jain, Cyrus Y Jin, Steven G Clarke

Proc Natl Acad Sci U S A· September 2017

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