Publications by authors named "Daan Ophelders"

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Multipotent adult progenitor cell therapy: Effect of timing and frequency on lung health in preterm lambs during inflammation.
Sophie M L Neuen, Daan R M G Ophelders, Helene Widowski, Matthias C Hütten, Tim Brokken

Pharmacol Res· November 2025

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Mesenchymal stem cells suppress NF-κB and ERK signalling while enhancing chemotaxis in CD4 T cells.
Ezgi Sengun, Janeri Fröberg, Xuehui He, Marc Eleveld, Ruben L Smeets, Daan R M G Ophelders

Sci Rep· August 2025

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Functional conduction system mapping in sheep reveals Purkinje spikes in the free wall of the right ventricular outflow tract.
Michiel Blok, Bram L den Ouden, Marion Kuiper, Daan R M G Ophelders, Monique R M Jongbloed

Front Physiol· July 2025

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Gold Mesoporous Silica-Coated Nanoparticles for Quantifying and Qualifying Mesenchymal Stem Cell Distribution; a Proof-of-Concept Study in Large Animals.
Lotte C C Smeets, Ezgi Sengun, Chloe Trayford, Bram van Cranenbroek, Marien I de Jonge, Daan R M G Ophelders

ACS Appl Bio Mater· February 2025

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Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs.
Sophie M L Neuen, Daan R M G Ophelders, Helene Widowski, Matthias C Hütten, Tim Brokken

Regen Ther· December 2024

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Optimized lung expansion ventilation modulates ventilation-induced lung injury in preterm lambs.
Tim Brokken, Matthias C Hütten, Daan R M G Ophelders, Charlotte van Gorp, Tim G A M Wolfs

Pediatr Pulmonol· November 2024

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Umbilical cord-mesenchymal stem cells induce a memory phenotype in CD4 T cells.
Ezgi Sengun, Tim G A M Wolfs, Valéry L E van Bruggen, Bram van Cranenbroek, Elles R Simonetti, Daan Ophelders

Front Immunol· July 2023

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Time Dependent Changes in the Ovine Neurovascular Unit; A Potential Neuroprotective Role of Annexin A1 in Neonatal Hypoxic-Ischemic Encephalopathy.
Hyun Young Park, Valéry L E van Bruggen, Carine J Peutz-Kootstra, Daan R M G Ophelders, Reint K Jellema

Int J Mol Sci· March 2023

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Acute Lung Functional and Airway Remodeling Effects of an Inhaled Highly Selective Phosphodiesterase 4 Inhibitor in Ventilated Preterm Lambs Exposed to Chorioamnionitis.
Matthias Christian Hütten, Tim Brokken, Helene Widowski, Tobias Monaco, Jan Philipp Schneider, Daan Ophelders

Pharmaceuticals (Basel)· December 2022

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Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis.
Luise Klein, Daan R M G Ophelders, Daniel van den Hove, Maurits Damoiseaux, Bart P F Rutten

Brain Behav Immun Health· August 2022

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Closed-Loop Control of Arterial CO in Mechanical Ventilation of Neonates.
Mateusz Buglowski, Valerie Pfannschmidt, Sabine Becker, Oliver Braun, Matthias Hutten, Daan Ophelders

Annu Int Conf IEEE Eng Med Biol Soc· July 2022

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Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero.
Helene Widowski, Daan R M G Ophelders, Anaïs J C N van Leeuwen, Peter G J Nikkels, Carmen A H Severens-Rijvers

Pediatr Res· September 2021

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Screening of Chorioamnionitis Using Volatile Organic Compound Detection in Exhaled Breath: A Pre-clinical Proof of Concept Study.
Daan R M G Ophelders, Agnes W Boots, Matthias C Hütten, Salwan Al-Nasiry, Reint K Jellema

Front Pediatr· May 2021

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Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells.
Helene Widowski, Niki L Reynaert, Daan R M G Ophelders, Matthias C Hütten, Peter G J Nikkels

Front Med (Lausanne)· February 2021

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Systemic multipotent adult progenitor cells protect the cerebellum after asphyxia in fetal sheep.
Ruth Gussenhoven, Daan R M G Ophelders, Jeroen Dudink, Kay Pieterman, Martin Lammens

Stem Cells Transl Med· January 2021

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A comparison of four different models of acute respiratory distress syndrome in sheep.
Monique Engel, Relana M E Nowacki, Elly M Jonker, Daan Ophelders, Maria Nikiforou

Respir Res· August 2020

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Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key.
Daan R M G Ophelders, Ruth Gussenhoven, Luise Klein, Reint K Jellema, Rob J J Westerlaken

Cells· August 2020

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Why -aVF can be used in STAN as a proxy for scalp electrode-derived signal; reply to comments by Kjellmer et al.
Tammo Delhaas, Peter Andriessen, Judith Oeh van Laar, Rik Vullings, Ben Jm Hermans, Daan Rmg Ophelders

PLoS One· February 2020

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Detrimental Effects of an Inhaled Phosphodiesterase-4 Inhibitor on Lung Inflammation in Ventilated Preterm Lambs Exposed to Chorioamnionitis Are Dose Dependent.
Matthias C Hütten, Markus Fehrholz, Franziska M Konrad, Daan Ophelders, Clementine Kleintjes

J Aerosol Med Pulm Drug Deliv· December 2019

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Electrical stimulation promotes the angiogenic potential of adipose-derived stem cells.
Jip Beugels, Daniel G M Molin, Daan R M G Ophelders, Teun Rutten, Lilian Kessels

Sci Rep· August 2019

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Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.
Ruth Gussenhoven, Luise Klein, Daan R M G Ophelders, Denise H J Habets, Bernd Giebel

J Clin Med· January 2019

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Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs.
Holger B Wahl, Matthias C Hütten, Dominik Monz, Erol Tutdibi, Daan Ophelders

J Aerosol Med Pulm Drug Deliv· December 2018

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ST waveform analysis for monitoring hypoxic distress in fetal sheep after prolonged umbilical cord occlusion.
Peter Andriessen, Alex Zwanenburg, Judith O E H van Laar, Rik Vullings, Ben J M Hermans, Daan R M G Ophelders

PLoS One· July 2018

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Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus.
Ruth Gussenhoven, Rob J J Westerlaken, Daan R M G Ophelders, Alan H Jobe, Matthew W Kemp

J Neuroinflammation· April 2018

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Evaluation of the Acute Pulmonary Response to Poractant Alfa and Bovactant Treatments in Lung-Lavaged Adult Rabbits and in Preterm Lambs with Respiratory Distress Syndrome.
Francesca Ricci, Fabrizio Salomone, Elke Kuypers, Daan Ophelders, Maria Nikiforou

Front Pediatr· August 2017

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