Publications by authors named "Dagmar Heydeck"

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Functional humanization of 15-lipoxygenase-1 (Alox15) protects mice from dextran sodium sulfate induced intestinal inflammation.
Florian Reisch, Marjann Schäfer, Dominika Labuz, Halina Machelska, Sabine Stehling, Dagmar Heydeck

Cell Mol Biol Lett· July 2025

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Eicosanoid biosynthesizing enzymes in Prototheria.
Kumar R Kakularam, Eda Gündem, Sabine Stehling, Michael Rothe, Dagmar Heydeck

Biochim Biophys Acta Mol Cell Biol Lipids· January 2025

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Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system.
Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang

Cell Mol Biol Lett· November 2023

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Bony Fish Arachidonic Acid 15-Lipoxygenases Exhibit Different Catalytic Properties than Their Mammalian Orthologs, Suggesting Functional Enzyme Evolution during Vertebrate Development.
Sophie Roigas, Kumar R Kakularam, Michael Rothe, Dagmar Heydeck, Polamarasetty Aparoy

Int J Mol Sci· September 2023

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Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund's adjuvant-induced paw inflammation model.
Dagmar Heydeck, Kumar R Kakularam, Dominika Labuz, Halina Machelska, Nadine Rohwer

Inflamm Res· August 2023

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Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models.
Marjann Schäfer, Florian Reisch, Dominika Labuz, Halina Machelska, Sabine Stehling, Dagmar Heydeck

Int J Mol Sci· July 2023

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Functional Characterization of Transgenic Mice Overexpressing Human 15-Lipoxygenase-1 (ALOX15) under the Control of the aP2 Promoter.
Dagmar Heydeck, Christoph Ufer, Kumar R Kakularam, Michael Rothe, Thomas Liehr

Int J Mol Sci· March 2023

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Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1) gain less body weight during adolescence and adulthood.
Bernhard Dumoulin, Dagmar Heydeck, Desiree Jähn, Moritz Lassé, Sajad Sofi

Cell Biosci· December 2022

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Functional Characterization of Novel Bony Fish Lipoxygenase Isoforms and Their Possible Involvement in Inflammation.
Sophie Roigas, Dagmar Heydeck, Hartmut Kuhn

Int J Mol Sci· December 2022

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Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging.
Marjann Schäfer, Kumar R Kakularam, Florian Reisch, Michael Rothe, Sabine Stehling, Dagmar Heydeck

Biomedicines· June 2022

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The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae.
Dagmar Heydeck, Florian Reisch, Marjann Schäfer, Kumar R Kakularam, Sophie A Roigas

Front Cell Dev Biol· April 2022

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Paralog- and ortholog-specificity of inhibitors of human and mouse lipoxygenase-isoforms.
Kumar Reddy Kakularam, Felix Karst, Aparoy Polamarasetty, Igor Ivanov, Dagmar Heydeck

Biomed Pharmacother· January 2022

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Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Mice.
Eugenia Marbach-Breitrück, Nadine Rohwer, Carmen Infante-Duarte, Silvina Romero-Suarez, Dominika Labuz, Dagmar Heydeck

Metabolites· October 2021

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Oxygenation of endocannabinoids by mammalian lipoxygenase isoforms.
Igor Ivanov, Kumar R Kakularam, Elena V Shmendel, Michael Rothe, Polamarasetty Aparoy, Dagmar Heydeck

Biochim Biophys Acta Mol Cell Biol Lipids· June 2021

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Eicosanoid biosynthesis in marine mammals.
Florian Reisch, Kumar Reddy Kakularam, Sabine Stehling, Dagmar Heydeck, Hartmut Kuhn

FEBS J· February 2021

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Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.
Bernhard Dumoulin, Christoph Ufer, Sabine Stehling, Dagmar Heydeck, Hartmut Kuhn

Biochim Biophys Acta Gen Subj· November 2020

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Corrigendum to "Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells" [BBA-Mol. Cell Biol. Volume 1863/2, Pages 152-164].
Maceler Aldrovandi, Swathi Banthiya, Sven Meckelmann, You Zhou, Dagmar Heydeck

Biochim Biophys Acta Mol Cell Biol Lipids· August 2020

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A role of Gln596 in fine-tuning mammalian ALOX15 specificity, protein stability and allosteric properties.
Alejandro Cruz, Almerinda Di Venere, Giampiero Mei, Alexander Zhuravlev, Alexey Golovanov, Dagmar Heydeck

Biochim Biophys Acta Mol Cell Biol Lipids· July 2020

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The lipoxygenase pathway of Tupaia belangeri representing Scandentia. Genomic multiplicity and functional characterization of the ALOX15 orthologs in the tree shrew.
Marjann Schäfer, Yu Fan, Tianle Gu, Dagmar Heydeck, Sabine Stehling

Biochim Biophys Acta Mol Cell Biol Lipids· February 2020

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Atopic Patients Show Increased Interleukin 4 Plasma Levels but the Degree of Elevation Is Not Sufficient to Upregulate Interleukin-4-Sensitive Genes.
Eugenia Marbach-Breitrück, Andrea Kalledat, Dagmar Heydeck, Sabine Stehling, Joachim W Fluhr

Skin Pharmacol Physiol· January 2020

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Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.
Eugenia Marbach-Breitrück, Laura Kutzner, Michael Rothe, Robert Gurke, Yannick Schreiber, Dagmar Heydeck

Antioxid Redox Signal· January 2020

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Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.
Igor Ivanov, Alexey B Golovanov, Cristián Ferretti, Miquel Canyelles-Niño, Dagmar Heydeck

ACS Chem Biol· December 2019

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Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns.
Kateryna Goloshchapova, Sabine Stehling, Dagmar Heydeck, Maximilian Blum, Hartmut Kuhn

Microbiologyopen· July 2019

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Functional characterization of novel ALOX15 orthologs representing key steps in mammalian evolution supports the Evolutionary Hypothesis of reaction specificity.
Nikita Kozlov, Lia Humeniuk, Christoph Ufer, Igor Ivanov, Alexey Golovanov, Dagmar Heydeck

Biochim Biophys Acta Mol Cell Biol Lipids· March 2019

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Do lipoxygenases occur in viruses?: Expression and characterization of a viral lipoxygenase-like protein did not provide evidence for the existence of functional viral lipoxygenases.
Tatjana Gehring, Dagmar Heydeck, Agathe Niewienda, Katharina Janek, Hartmut Kuhn

Prostaglandins Leukot Essent Fatty Acids· November 2018

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