Publications by authors named "Daigo Asano"

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Tissue distribution of renadirsen sodium, a dystrophin exon-skipping antisense oligonucleotide, in heart and diaphragm after subcutaneous administration to cynomolgus monkeys.
Naotoshi Yamamura, Hideo Takakusa, Daigo Asano, Kyoko Watanabe, Yukari Shibaya

Nucleosides Nucleotides Nucleic Acids· June 2025

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Oral Absorption of Middle-to-Large Molecules and Its Improvement, with a Focus on New Modality Drugs.
Daigo Asano, Hideo Takakusa, Daisuke Nakai

Pharmaceutics· December 2023

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-Aryl Indoles as a Novel Class of Potent Na1.7 Inhibitors.
Narayan Karanjule, Noriyuki Hayashi, Sayaka Suzuki, Toshifumi Tsuda, Eri Tokumaru, Daigo Asano

ACS Med Chem Lett· June 2023

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Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver.
Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa

Drug Metab Dispos· January 2023

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CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate.
Daigo Asano, Syoya Hamaue, Hamim Zahir, Hideyuki Shiozawa, Yumi Nishiya

Drug Metab Dispos· March 2022

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Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator.
Mayuko Akiu, Takashi Tsuji, Kouki Iida, Yoshitaka Sogawa, Koji Terayama, Daigo Asano

Chem Pharm Bull (Tokyo)· December 2021

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Evaluation of species differences in the metabolism of the selective Na1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase.
Daigo Asano, Takahiro Shibayama, Hideyuki Shiozawa, Shin-Ichi Inoue, Tsuyoshi Shinozuka

Xenobiotica· September 2021

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Renadirsen, a Novel 2'OMeRNA/ENA Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo.
Kentaro Ito, Hideo Takakusa, Masayo Kakuta, Akira Kanda, Nana Takagi, Daigo Asano

Curr Issues Mol Biol· September 2021

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Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.
Mayuko Akiu, Takashi Tsuji, Yoshitaka Sogawa, Koji Terayama, Mika Yokoyama, Daigo Asano

Bioorg Med Chem Lett· July 2021

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Discovery of a Novel Class of State-Dependent Na1.7 Inhibitors for the Treatment of Neuropathic Pain.
Kyosuke Tanaka, Hiroyuki Kobayashi, Sayaka Suzuki, Satoshi Shibuya, Hiroko Kimoto, Daigo Asano

Chem Pharm Bull (Tokyo)· February 2021

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Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity.
Akihiro Furukawa, Joshua Schwochert, Cameron R Pye, Daigo Asano, Quinn D Edmondson

Angew Chem Int Ed Engl· November 2020

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Discovery of DS-1971a, a Potent, Selective Na1.7 Inhibitor.
Tsuyoshi Shinozuka, Hiroyuki Kobayashi, Sayaka Suzuki, Kyosuke Tanaka, Narayan Karanjule, Daigo Asano

J Med Chem· September 2020

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Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors.
Sayaka Suzuki, Takeshi Kuroda, Hiroko Kimoto, Yuki Domon, Kazufumi Kubota, Daigo Asano

Bioorg Med Chem Lett· November 2015

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Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability--analysis in hypercholesterolemic rabbits.
Seigo Ishino, Takahiro Mukai, Noriaki Kume, Daigo Asano, Mikako Ogawa

Atherosclerosis· November 2007

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Establishment of evaluation method for siRNA delivery using stable cell line carrying the luciferase reporter gene.
Ayako Iijima, Rei Hachisu, Hideo Kobayashi, Kouichi Hashimoto, Daigo Asano

Biol Pharm Bull· October 2007

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Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors.
Hirofumi Hanaoka, Takahiro Mukai, Sayo Habashita, Daigo Asano, Kazuma Ogawa

Nucl Med Biol· July 2007

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Therapeutic effects of a 186Re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model.
Kazuma Ogawa, Takahiro Mukai, Daigo Asano, Hidekazu Kawashima, Seigo Kinuya

J Nucl Med· January 2007

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(18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study.
Mikako Ogawa, Seigo Ishino, Takahiro Mukai, Daigo Asano, Noboru Teramoto

J Nucl Med· July 2004

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