Publications by authors named "Dale Grabowski"

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Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia.
Yihong Guan, Metis Hasipek, Dongxu Jiang, Anand D Tiwari, Dale R Grabowski

J Clin Invest· February 2022

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SAR insights into TET2 catalytic domain inhibition: Synthesis of 2-Hydroxy-4-Methylene-pentanedicarboxylates.
Anand D Tiwari, Yihong Guan, Dale R Grabowski, Jaroslaw P Maciejewski, Babal K Jha

Bioorg Med Chem· June 2021

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Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma.
Metis Hasipek, Dale Grabowski, Yihong Guan, Raghunandan Reddy Alugubelli, Anand D Tiwari

Cancers (Basel)· May 2021

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Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network.
Xiaorong Gu, Rita Tohme, Benjamin Tomlinson, Nneha Sakre, Metis Hasipek, Dale Grabowski

Leukemia· April 2021

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A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms.
Yihong Guan, Anand D Tiwari, James G Phillips, Metis Hasipek, Dale R Grabowski

Blood Cancer Discov· March 2021

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DNA methylation inhibition in myeloma: Experience from a phase 1b study of low-dose continuous azacitidine in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma.
Jack Khouri, Beth M Faiman, Dale Grabowski, Reda Z Mahfouz, Shahper N Khan

Semin Hematol· January 2021

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Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.
Toshiyuki Kozuki, Kenichi Chikamori, Marius D Surleac, Marius A Micluta, Andrei J Petrescu, Dale R Grabowski

Nucleic Acids Res· June 2017

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Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.
Sergei Vatolin, James G Phillips, Babal K Jha, Shravya Govindgari, Jennifer Hu, Dale Grabowski

Cancer Res· June 2016

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Inhibition of proteasome activity by bortezomib in renal cancer cells is p53 dependent and VHL independent.
Susan A J Vaziri, Dale R Grabowski, Jason Hill, Lisa R Rybicki, Robert Burk

Anticancer Res· August 2009

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Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.
Adrian G Grozav, Kenichi Chikamori, Toshiyuki Kozuki, Dale R Grabowski, Ronald M Bukowski

Nucleic Acids Res· February 2009

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Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms.
Nagio Takigawa, Susan A J Vaziri, Dale R Grabowski, Kenichi Chikamori, Lisa R Rybicki

Anticancer Res· August 2006

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Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin.
Susan A J Vaziri, Jason Hill, Kenichi Chikamori, Dale R Grabowski, Nagio Takigawa

Mol Cancer Ther· December 2005

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c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis.
Susan A Vaziri, Dale R Grabowski, Masahiro Tabata, Katherine A Holmes, Joseph Sterk

Anticancer Res· February 2004

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Apoptotic pathways of epothilone BMS 310705.
Denise Uyar, Nagio Takigawa, Tarek Mekhail, Dale Grabowski, Maurie Markman

Gynecol Oncol· October 2003

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Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
Kenichi Chikamori, Dale R Grabowski, Michael Kinter, Belinda B Willard, Satya Yadav

J Biol Chem· April 2003

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Inhibition of NF-kappaB and proteasome activity in tumors: can we improve the therapeutic potential of topoisomerase I and topoisomerase II poisons.
Ram Ganapathi, Susan A J Vaziri, Masahiro Tabata, Nagio Takigawa, Dale R Grabowski

Curr Pharm Des· March 2003

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