Publications by authors named "Daniel A Keedy"

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Three STEPs Forward: A Trio of Unexpected Structures of PTPN5.
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Sean H Kim, Anthony C Bishop, Daniel A Keedy

Proteins· December 2025

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Orchestrating function: Concerted dynamics, allostery, and catalysis in protein tyrosine phosphatases.
Virgil A Woods, Shivani Sharma, Alexis M Lemberikman, Daniel A Keedy

Curr Opin Struct Biol· October 2025

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Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites.
Aliki Perdikari, Virgil A Woods, Ali Ebrahim, Katherine Lawler, Rebecca Bounds, Daniel A Keedy

J Biol Chem· October 2025

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Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models.
Akshay Raju, Shivani Sharma, Blake T Riley, Shakhriyor Djuraev, Yingxian Tan, Daniel A Keedy

bioRxiv· May 2025

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Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Aliki Perdikari, Virgil A Woods, Ali Ebrahim, Katherine Lawler, Rebecca Bounds, Daniel A Keedy

bioRxiv· March 2025

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Structure-Based Experimental Datasets for Benchmarking Protein Simulation Force Fields [Article v0.1].
Chapin E Cavender, David A Case, Julian C-H Chen, Lillian T Chong, Daniel A Keedy

ArXiv· March 2025

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Three STEPs forward: A trio of unexpected structures of PTPN5.
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Sean H Kim, Anthony C Bishop, Daniel A Keedy

bioRxiv· February 2025

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Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR () Phosphatase.
Jiaqian Wu, Marek R Baranowski, Alexander E Aleshin, Eta A Isiorho, Lester J Lambert, Daniel A Keedy

ACS Omega· February 2025

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Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction.
Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Andrew C Johns, Daniel A Keedy

Protein Sci· January 2025

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Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction.
Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Andrew C Johns, Daniel A Keedy

bioRxiv· November 2024

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An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data.
Tamar Mehlman, Helen M Ginn, Daniel A Keedy

Structure· August 2024

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Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS.
Virgil A Woods, Rinat R Abzalimov, Daniel A Keedy

Protein Sci· June 2024

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Automated multiconformer model building for X-ray crystallography and cryo-EM.
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake Riley, Akshay Raju, Daniel A Keedy

Elife· June 2024

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Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM.
Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake T Riley, Akshay Raju, Daniel A Keedy

bioRxiv· April 2024

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High-resolution double vision of the allosteric phosphatase PTP1B.
Shivani Sharma, Tamar Skaist Mehlman, Reddy Sudheer Sagabala, Benoit Boivin, Daniel A Keedy

Acta Crystallogr F Struct Biol Commun· January 2024

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Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP.
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Daniel A Keedy

Commun Biol· January 2024

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An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data.
Tamar Skaist Mehlman, Helen M Ginn, Daniel A Keedy

bioRxiv· January 2024

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Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS.
Virgil A Woods, Rinat R Abzalimov, Daniel A Keedy

bioRxiv· November 2023

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Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase.
Liliana Guerrero, Ali Ebrahim, Blake T Riley, Minyoung Kim, Qingqiu Huang, Daniel A Keedy

bioRxiv· May 2023

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Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B.
Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Daniel A Keedy

Elife· March 2023

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Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B.
Shivani Sharma, Ali Ebrahim, Daniel A Keedy

Acta Crystallogr F Struct Biol Commun· January 2023

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The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M).
Ali Ebrahim, Blake T Riley, Desigan Kumaran, Babak Andi, Martin R Fuchs, Daniel A Keedy

IUCrJ· September 2022

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The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M).
Ali Ebrahim, Blake T Riley, Desigan Kumaran, Babak Andi, Martin R Fuchs, Daniel A Keedy

bioRxiv· November 2021

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qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps.
Blake T Riley, Stephanie A Wankowicz, Saulo H P de Oliveira, Gydo C P van Zundert, Daniel W Hogan, Daniel A Keedy

Protein Sci· January 2021

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Journey to the center of the protein: allostery from multitemperature multiconformer X-ray crystallography.
Daniel A Keedy

Acta Crystallogr D Struct Biol· February 2019

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