Publications by authors named "Daniel A Tennant"

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Substrate stiffness-dependent metabolic reprogramming of iPSC-derived cardiomyocytes on physiological PDMS polymers.
Leena Patel, Bryan P Marzullo, Jonathan Barlow, Himani Rana, Amar J Azad, Daniel A Tennant

Metab Eng Commun· December 2025

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mTOR activity and metabolic reprogramming of CD8+ T cells is impaired under hypoxia and within the multiple myeloma bone marrow.
Taylor Fulton-Ward, Nancy Gudgeon, Isaac Thirlwell, Emma L Bishop, Bryan Marzullo, Daniel A Tennant

Blood Adv· December 2025

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Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production.
Maureen Yin, Eva M Palsson-McDermott, Órlaith C Henry, Ziqian Ge, Juliana E Toller-Kawahisa, Daniel A Tennant

Sci Rep· December 2025

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Intracrine FFA4 signaling controls lipolysis at lipid droplets.
Shannon L O'Brien, Emma Tripp, Natasja Barki, Elodie Blondel-Tepaz, Gabrielle Smith, Daniel A Tennant

Nat Chem Biol· August 2025

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Iron deficiency causes aspartate-sensitive dysfunction in CD8 T cells.
Megan R Teh, Nancy Gudgeon, Joe N Frost, Linda V Sinclair, Alastair L Smith, Daniel A Tennant

Nat Commun· June 2025

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A Mathematical Exploration of SDH-b Loss in Chromaffin Cells.
Elías Vera-Sigüenza, Himani Rana, Ramin Nashebi, Ielyaas Cloete, Katarína Kl'uvčková, Daniel A Tennant

Bull Math Biol· March 2025

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Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase.
Katerina Hlozkova, Maryna Vasylkivska, Adam Boufersaoui, Bryan Marzullo, Matus Kolarik, Daniel A Tennant

Cancer Lett· November 2024

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LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells.
Federica Cuozzo, Katrina Viloria, Ali H Shilleh, Daniela Nasteska, Charlotte Frazer-Morris, Daniel A Tennant

Cell Rep· April 2024

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TNF-α signals through ITK-Akt-mTOR to drive CD4 T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis.
Emma L Bishop, Nancy Gudgeon, Taylor Fulton-Ward, Victoria Stavrou, Jennie Roberts, Daniel A Tennant

Sci Signal· April 2024

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Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia.
Dora Ravasz, David Bui, Sara Nazarian, Gergely Pallag, Noemi Karnok, Daniel A Tennant

Sci Rep· January 2024

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The glucocorticoid dexamethasone inhibits HIF-1α stabilization and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages.
Sally A Clayton, Chloe Lockwood, John D O'Neil, Kalbinder K Daley, Sofia Hain, Daniel A Tennant

Discov Immunol· December 2023

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VHL-deficiency leads to reductive stress in renal cells.
Hans Vellama, Kattri-Liis Eskla, Hillar Eichelmann, Andria Hüva, Daniel A Tennant

Free Radic Biol Med· November 2023

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Uptake of long-chain fatty acids from the bone marrow suppresses CD8+ T-cell metabolism and function in multiple myeloma.
Nancy Gudgeon, Hannah Giles, Emma L Bishop, Taylor Fulton-Ward, Cristina Escribano-Gonzalez, Daniel A Tennant

Blood Adv· October 2023

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Interplay of p53 and XIAP protein dynamics orchestrates cell fate in response to chemotherapy.
Roba Abukwaik, Elias Vera-Siguenza, Daniel A Tennant, Fabian Spill

J Theor Biol· September 2023

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Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL.
Julius Lukes, Eliska Potuckova, Natividad Alquezar-Artieda, Ivana Hermanova, Sladjana Kosanovic, Daniel A Tennant

Hemasphere· September 2023

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Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy.
Natividad Alquezar-Artieda, Daniela Kuzilkova, Jennie Roberts, Katerina Hlozkova, Alena Pecinova, Daniel A Tennant

Blood Adv· May 2023

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Congxin Sun, Elena Seranova, Malkiel A Cohen, Miruna Chipara, Jennie Roberts, Daniel A Tennant

Cell Rep· May 2023

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Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation.
Nancy Gudgeon, Haydn Munford, Emma L Bishop, James Hill, Taylor Fulton-Ward, Daniel A Tennant

Cell Rep· August 2022

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1,25-Dihydroxyvitamin D3 suppresses CD4 T-cell effector functionality by inhibition of glycolysis.
Emma L Bishop, Nancy H Gudgeon, Gillian M Mackie, Daniel Chauss, Jennie Roberts, Daniel A Tennant

Immunology· July 2022

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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Rebecca L Westbrook, Esther Bridges, Jennie Roberts, Cristina Escribano-Gonzalez, Katherine L Eales, Daniel A Tennant

Cell Rep· February 2022

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Proline metabolism and redox; maintaining a balance in health and disease.
Lisa A Vettore, Rebecca L Westbrook, Daniel A Tennant

Amino Acids· December 2021

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Inflammation causes remodeling of mitochondrial cytochrome oxidase mediated by the bifunctional gene .
Sally A Clayton, Kalbinder K Daley, Lucy MacDonald, Erika Fernandez-Vizarra, Giovanni Bottegoni, Daniel A Tennant

Sci Adv· December 2021

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Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice.
Daniela Nasteska, Federica Cuozzo, Katrina Viloria, Elspeth M Johnson, Alpesh Thakker, Daniel A Tennant

JCI Insight· August 2021

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Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Judith Goncalves, Sophie Moog, Aurélie Morin, Géraldine Gentric, Sebastian Müller, Daniel A Tennant

Cancer Res· July 2021

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Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.
Eamon Fitzgerald, Jennie Roberts, Daniel A Tennant, James P Boardman, Amanda J Drake

Sci Rep· April 2021

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