Publications by authors named "Daniel C-H Lin"

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A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery.
Tracy Tran, Cheng Jack Song, Trang Nguyen, Shun-Yang Cheng, Jill A McMahon, Balint Der, Nils O Lindström, Daniel C-H Lin

Cell Stem Cell· July 2022

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Structural basis for pharmacological modulation of the TRPC6 channel.
Yonghong Bai, Xinchao Yu, Hao Chen, Daniel Horne, Ryan White, Daniel C-H Lin

Elife· March 2020

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Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates.
Sean P Brown, Paul Dransfield, Marc Vimolratana, Liusheng Zhu, Jian Luo, Daniel C-H Lin

ACS Med Chem Lett· July 2018

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Discovery of the imidazole-derived GPR40 agonist AM-3189.
Zhihua Ma, Daniel C-H Lin, Rajiv Sharma, Jinqian Liu, Liusheng Zhu

Bioorg Med Chem Lett· January 2016

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Optimization of GPR40 Agonists for Type 2 Diabetes.
Jiwen Jim Liu, Yingcai Wang, Zhihua Ma, Mike Schmitt, Liusheng Zhu, Daniel C-H Lin

ACS Med Chem Lett· May 2014

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Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists.
Xiaohui Du, Paul J Dransfield, Daniel C-H Lin, Simon Wong, Yingcai Wang

ACS Med Chem Lett· April 2014

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Modulating GPR40: therapeutic promise and potential in diabetes.
Vincent Poitout, Daniel C-H Lin

Drug Discov Today· December 2013

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Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.
Ming Yu, Mike Lizarzaburu, Alykhan Motani, Zice Fu, Xiaohui Du, Daniel C-H Lin

ACS Med Chem Lett· September 2013

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A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.
Jian Luo, Gayathri Swaminath, Sean P Brown, Jane Zhang, Qi Guo, Daniel C-H Lin

PLoS One· June 2013

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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles.
Yingcai Wang, Jiwen Jim Liu, Paul J Dransfield, Liusheng Zhu, Zhongyu Wang, Daniel C-H Lin

ACS Med Chem Lett· June 2013

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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.
Yumei Xiong, Gayathri Swaminath, Qiong Cao, Li Yang, Qi Guo, Daniel C-H Lin

Mol Cell Endocrinol· April 2013

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Evaluating insulin secretagogues in a humanized mouse model with functional human islets.
Jian Luo, Kathy Nguyen, Michael Chen, Than Tran, Jianqiang Hao, Daniel C-H Lin

Metabolism· January 2013

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Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor.
Daniel C-H Lin, Qi Guo, Jian Luo, Jane Zhang, Kathy Nguyen

Mol Pharmacol· November 2012

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Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.
Sean P Brown, Paul J Dransfield, Marc Vimolratana, XianYun Jiao, Liusheng Zhu, Daniel C-H Lin

ACS Med Chem Lett· September 2012

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AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents.
Daniel C-H Lin, Jane Zhang, Run Zhuang, Frank Li, Kathy Nguyen, Jenny Ying Lin Lu, Yi-Jyun Lin

PLoS One· May 2012

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AMG 837: a potent, orally bioavailable GPR40 agonist.
Jonathan B Houze, Liusheng Zhu, Ying Sun, Michelle Akerman, Wei Qiu, Jenny Ying-Lin Lu, Daniel C-H Lin

Bioorg Med Chem Lett· January 2012

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GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.
Martin G Latour, Thierry Alquier, Elizabeth Oseid, Caroline Tremblay, Thomas L Jetton, Daniel C-H Lin

Diabetes· April 2007

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Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.
Weihai He, Frederick J-P Miao, Daniel C-H Lin, Ralf T Schwandner, Zhulun Wang, Lei Ling

Nature· May 2004

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