Publications by authors named "Daniel Downes"

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An Ultra-High Throughput Cell-Based Mass Spectrometry Flux Assay as a Pathway-Selective In Situ Screening Approach.
Daniel P Downes, Christopher M Barbieri, David Connors, Madhu Sudhan Ravindran, Debarati M Tagore

Anal Chem· September 2025

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Discovery and Synthesis of Heterobifunctional Degraders of Rearranged during Transfection (RET) Kinase.
Jennifer X Qiao, David Williams, Patrice Gill, Ling Li, Derek Norris, Daniel P Downes

J Med Chem· November 2024

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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.
Santhosh Satapati, Daniel P Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar

SLAS Discov· January 2022

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Engineering the Next Generation of Matched Models for Chemical Translational Biology.
Daniel P Downes

Chembiochem· February 2021

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Key Concepts Surrounding Studies of Stable Isotope-Resolved Metabolomics.
Stephen F Previs, Daniel P Downes

Methods Mol Biol· January 2021

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Mapping Lipogenic Flux: A Gold LDI-MS Approach for Imaging Neutral Lipid Kinetics.
Daniel P Downes, Wendy Zhong, Ji Zhang, Bingming Chen, Santhosh Satapati

J Am Soc Mass Spectrom· December 2020

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Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of H-Labeling of Small Molecules.
Daniel P Downes, Takhar Kasumov, Natalie A Daurio, Neil B Wood, Michael J Previs

Metabolites· November 2020

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Impact of Extracellular Fatty Acids and Oxygen Tension on Lipid Synthesis and Assembly in Pancreatic Cancer Cells.
Daniel P Downes, Natalie A Daurio, David G McLaren, Paul Carrington, Stephen F Previs

ACS Chem Biol· July 2020

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Spatial and temporal studies of metabolic activity: contrasting biochemical kinetics in tissues and pathways during fasted and fed states.
Natalie A Daurio, Yichen Wang, Ying Chen, Haihong Zhou, Ester Carballo-Jane, Daniel P Downes

Am J Physiol Endocrinol Metab· June 2019

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Characterization of Brain Metabolism by Nuclear Magnetic Resonance.
Daniel P Downes, James H P Collins, Bimala Lama, Huadong Zeng, Tan Nguyen

Chemphyschem· January 2019

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Expeditious dissolution dynamic nuclear polarization without glassing agents.
Bimala Lama, James H P Collins, Daniel Downes, Adam N Smith, Joanna R Long

NMR Biomed· March 2016

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Modified murine intracranial aneurysm model: aneurysm formation and rupture by elastase and hypertension.
Koji Hosaka, Daniel P Downes, Kamil W Nowicki, Brian L Hoh

J Neurointerv Surg· July 2014

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Stromal cell-derived factor-1 promoted angiogenesis and inflammatory cell infiltration in aneurysm walls.
Brian L Hoh, Koji Hosaka, Daniel P Downes, Kamil W Nowicki, Erin N Wilmer

J Neurosurg· January 2014

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Monocyte chemotactic protein-1 promotes inflammatory vascular repair of murine carotid aneurysms via a macrophage inflammatory protein-1α and macrophage inflammatory protein-2-dependent pathway.
Brian L Hoh, Koji Hosaka, Daniel P Downes, Kamil W Nowicki, Cristina E Fernandez

Circulation· November 2011

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