Publications by authors named "Daniel Hunziker"

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Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non‑zinc binding mode.
Rainer E Martin, Alexander L Satz, Christoph Kuratli, Daniel Hunziker, Patrizio Mattei

Bioorg Med Chem Lett· August 2025

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Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.
Johannes Aebi, Kenneth Atz, Simon M Ametamey, Jörg Benz, Julie Blaising, Daniel Hunziker

Chimia (Aarau)· August 2024

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Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor.
Jürgen Wichmann, Caroline Rynn, Thomas Friess, Jeannine Petrig-Schaffland, Martin Kornacker, Daniel Hunziker

Clin Cancer Res· February 2022

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Synthesis, Characterization, and Evaluation of a Novel Potent Autotaxin-Inhibitor.
Daniel Hunziker, Sabrina Reinehr, Marina Palmhof, Natalie Wagner, Thomas Biniasch

Front Pharmacol· January 2022

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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.
David M Shackleford, Francis C K Chiu, Kasiram Katneni, Scott Blundell, Jenna McLaren, Daniel Hunziker

ACS Infect Dis· July 2021

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Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.
Leona T Y Ho, Anja Osterwald, Iris Ruf, Daniel Hunziker, Patrizio Mattei

Biochim Biophys Acta Mol Basis Dis· January 2020

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.
Werner Neidhart, Jean Ackermann, Kurt Amrein, Aurelia Conte, Daniel Hunziker

Chimia (Aarau)· December 2015

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.
Werner Neidhart, Jean Ackermann, Kurt Amrein, Aurelia Conte, Daniel Hunziker

Chimia (Aarau)· August 2015

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Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.
Markus Boehringer, Holger Fischer, Michael Hennig, Daniel Hunziker, Joerg Huwyler

Bioorg Med Chem Lett· February 2010

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Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
Lin Zhou, André Alker, Armin Ruf, Xiaofang Wang, Francis C K Chiu, Daniel Hunziker

Bioorg Med Chem Lett· March 2008

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1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors.
Thomas Lübbers, Markus Böhringer, Luca Gobbi, Michael Hennig, Daniel Hunziker

Bioorg Med Chem Lett· June 2007

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Inhibitors of dipeptidyl peptidase IV--recent advances and structural views.
Daniel Hunziker, Michael Hennig, Jens-Uwe Peters

Curr Top Med Chem· June 2006

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Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis.
Ingo V Hartung, Mathew A Rude, Nathan A Schnarr, Daniel Hunziker, Chaitan Khosla

J Am Chem Soc· August 2005

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Identification of an antimalarial synthetic trioxolane drug development candidate.
Jonathan L Vennerstrom, Sarah Arbe-Barnes, Reto Brun, Susan A Charman, Francis C K Chiu, Daniel Hunziker

Nature· August 2004

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An aminomethylpyrimidine DPP-IV inhibitor with improved properties.
Jens-Uwe Peters, Daniel Hunziker, Holger Fischer, Manfred Kansy, Silja Weber

Bioorg Med Chem Lett· July 2004

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Novel ketolide antibiotics with a fused five-membered lactone ring--synthesis, physicochemical and antimicrobial properties.
Daniel Hunziker, Pierre-C Wyss, Peter Angehrn, Aranka Mueller, Hans-Peter Marty

Bioorg Med Chem· July 2004

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A host-vector system for analysis and manipulation of rifamycin polyketide biosynthesis in Amycolatopsis mediterranei.
Zhihao Hu, Daniel Hunziker, C Richard Hutchinson, Chaitan Khosla

Microbiology (Reading)· September 1999

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