Publications by authors named "Daniel Ley"

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Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells.
Hooman Hefzi, Iván Martínez-Monge, Igor Marin de Mas, Nicholas Luke Cowie, Alejandro Gomez Toledo, Daniel Ley

Nat Metab· January 2025

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Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells.
Hooman Hefzi, Iván Martínez-Monge, Igor Marin de Mas, Nicholas Luke Cowie, Alejandro Gomez Toledo, Daniel Ley

bioRxiv· August 2024

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Multiplex secretome engineering enhances recombinant protein production and purity.
Stefan Kol, Daniel Ley, Tune Wulff, Marianne Decker, Johnny Arnsdorf

Nat Commun· April 2020

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Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion.
Jahir M Gutierrez, Amir Feizi, Shangzhong Li, Thomas B Kallehauge, Hooman Hefzi, Daniel Ley

Nat Commun· January 2020

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BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effects.
Sara Pereira, Daniel Ley, Mikkel Schubert, Lise Marie Grav, Helene Faustrup Kildegaard

J Biotechnol· December 2019

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Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion.
Daniel Ley, Sara Pereira, Lasse Ebdrup Pedersen, Johnny Arnsdorf, Hooman Hefzi

Metab Eng· December 2019

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Fed-Batch CHO Cell Culture for Lab-Scale Antibody Production.
Yuzhou Fan, Daniel Ley, Mikael Rørdam Andersen

Methods Mol Biol· May 2018

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Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion.
Thomas Beuchert Kallehauge, Shangzhong Li, Lasse Ebdrup Pedersen, Tae Kwang Ha, Daniel Ley

Sci Rep· January 2017

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A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.
Hooman Hefzi, Kok Siong Ang, Michael Hanscho, Aarash Bordbar, David Ruckerbauer, Daniel Ley

Cell Syst· November 2016

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Multi-omic profiling -of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production.
Daniel Ley, Ali Kazemi Seresht, Mikael Engmark, Olivera Magdenoska, Kristian Fog Nielsen

Biotechnol Bioeng· November 2015

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N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
Kwan Young Lee, Sara E Royston, Max O Vest, Daniel J Ley, Seungbae Lee

Mol Brain· January 2015

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Characterization of AmiBA2446, a novel bacteriolytic enzyme active against Bacillus species.
Krunal K Mehta, Elena E Paskaleva, Saba Azizi-Ghannad, Daniel J Ley, Martin A Page

Appl Environ Microbiol· October 2013

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