Publications by authors named "Daniel Rosoff"

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Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study.
Joshua Reitz, Daniel B Rosoff, Tyler Perlstein, Alexandra Wagner, Jeesun Jung

Mol Psychiatry· December 2025

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Alcohol and aging: Next-generation epigenetic clocks predict biological age acceleration in individuals with alcohol use disorder.
Tyler A Perlstein, Jeesun Jung, Alexandra C Wagner, Joshua Reitz, Josephin Wagner, Daniel B Rosoff

Alcohol Clin Exp Res (Hoboken)· April 2025

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LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity.
Nellie Y Loh, Senthil K Vasan, Daniel B Rosoff, Emile Roberts, Andrea D van Dam

Commun Med (Lond)· February 2025

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Multiomic Mendelian Randomization Study Investigating the Impact of PCSK9 and HMGCR Inhibition on Type 2 Diabetes Across Five Populations.
Daniel B Rosoff, Josephin Wagner, Jeesun Jung, Pal Pacher, Constantinos Christodoulides

Diabetes· January 2025

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A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking.
Daniel B Rosoff, Josephin Wagner, Andrew S Bell, Lucas A Mavromatis, Jeesun Jung

Nat Hum Behav· January 2025

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Bidirectional Mendelian Randomization Highlights Causal Relationships Between Circulating INHBC and Multiple Cardiometabolic Diseases and Traits.
Nellie Y Loh, Daniel B Rosoff, Rebecca Richmond, Raymond Noordam, George Davey Smith

Diabetes· December 2024

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Major Psychiatric Disorders, Substance Use Behaviors, and Longevity.
Daniel B Rosoff, Ali M Hamandi, Andrew S Bell, Lucas A Mavromatis, Lauren M Park

JAMA Psychiatry· September 2024

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PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury.
Josephin Wagner, Lauren M Park, Partha Mukhopadhyay, Csaba Matyas, Eszter Trojnar, Daniel B Rosoff

Brain Behav Immun· July 2024

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LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells.
Federica Cuozzo, Katrina Viloria, Ali H Shilleh, Daniela Nasteska, Charlotte Frazer-Morris, Daniel B Rosoff

Cell Rep· April 2024

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Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study.
Daniel B Rosoff, Andrew S Bell, Lucas A Mavromatis, Ali Hamandi, Lauren Park

Circ Genom Precis Med· February 2024

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Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries.
Daniel B Rosoff, Andrew S Bell, Josephin Wagner, Lucas A Mavromatis, Ali Hamandi

Cell Mol Gastroenterol Hepatol· December 2023

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Investigating the impact of metabolic syndrome traits on telomere length: a Mendelian randomization study.
Nellie Y Loh, Daniel Rosoff, Raymond Noordam, Constantinos Christodoulides

Obesity (Silver Spring)· August 2023

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Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.
Daniel B Rosoff, Lucas A Mavromatis, Andrew S Bell, Josephin Wagner, Jeesun Jung

Nat Aging· August 2023

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system.
Andrew S Bell, Josephin Wagner, Daniel B Rosoff, Falk W Lohoff

Neurosci Biobehav Rev· June 2023

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Multi-omic underpinnings of epigenetic aging and human longevity.
Lucas A Mavromatis, Daniel B Rosoff, Andrew S Bell, Jeesun Jung, Josephin Wagner

Nat Commun· April 2023

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Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder.
Jeesun Jung, Daniel L McCartney, Josephin Wagner, Joyce Yoo, Andrew S Bell, Daniel B Rosoff

Biol Psychiatry· February 2023

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Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomization Study.
Andrew S Bell, Daniel B Rosoff, Lucas A Mavromatis, Jeesun Jung, Josephin Wagner

J Am Heart Assoc· November 2022

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Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging.
Jeesun Jung, Daniel L McCartney, Josephin Wagner, Daniel B Rosoff, Melanie Schwandt

Mol Psychiatry· September 2022

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Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study.
Lucas A Mavromatis, Daniel B Rosoff, Renata B Cupertino, Hugh Garavan, Scott Mackey

JAMA Psychiatry· September 2022

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Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function.
Daniel B Rosoff, Andrew S Bell, Jeesun Jung, Josephin Wagner, Lucas A Mavromatis

J Am Coll Cardiol· August 2022

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Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target.
Falk W Lohoff, Toni-Kim Clarke, Zachary A Kaminsky, Rosie M Walker, Mairead L Bermingham, Daniel Rosoff

Mol Psychiatry· March 2022

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Smoking is significantly associated with increased risk of COVID-19 and other respiratory infections.
Daniel B Rosoff, Joyce Yoo, Falk W Lohoff

Commun Biol· October 2021

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Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis.
Daniel B Rosoff, George Davey Smith, Falk W Lohoff

JAMA Psychiatry· February 2021

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A genetically-informed study disentangling the relationships between tobacco smoking, cannabis use, alcohol consumption, substance use disorders and respiratory infections, including COVID-19.
Daniel B Rosoff, Joyce Yoo, Falk W Lohoff

medRxiv· February 2021

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Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study.
Daniel B Rosoff, George Davey Smith, Nehal Mehta, Toni-Kim Clarke, Falk W Lohoff

PLoS Med· December 2020

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