Publications by authors named "Daniel Scotcher"

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Assessing Drug-mediated Inhibition of Liver Transporter Function with MRI: A First-in-Human Study.
Thazin Min, Marta Tibiletti, Paul D Hockings, Aleksandra Galetin, Ebony Gunwhy, Daniel Scotcher

Radiology· December 2025

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Evaluation of Adefovir PBPK Model to Assess Biomarker-Informed OAT1 Drug-Drug Interaction and Effect of Chronic Kidney Disease.
Shawn Pei Feng Tan, Huaying Wu, Amin Rostami-Hodjegan, Daniel Scotcher, Aleksandra Galetin

CPT Pharmacometrics Syst Pharmacol· May 2025

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Genotype, Ethnicity, and Drug-Drug Interaction Modeling as Means of Verifying Transporter Biomarker PBPK Model: The Coproporphyrin-I Story.
Yuki Ujihira, Shawn Pei Feng Tan, Daniel Scotcher, Aleksandra Galetin

CPT Pharmacometrics Syst Pharmacol· May 2025

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Publisher Correction: Generating Realistic Albumin Concentrations in Virtual Subjects Across A Spectrum of Renal Function to Account for Variability in Protein Binding Within PBPK Models.
Yuming Hu, Daniel Scotcher

AAPS J· May 2025

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Realistic Albumin Concentrations in Virtual Subjects Across A Spectrum of Renal Function to Account for Variability in Protein Binding Within PBPK Models.
Yuming Hu, Daniel Scotcher

AAPS J· April 2025

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Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates.
Nihan Izat, Jayaprakasam Bolleddula, Pasquale Carione, Leticia Huertas Valentin, Robert S Jones, Daniel Scotcher

CPT Pharmacometrics Syst Pharmacol· January 2025

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Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance.
Shawn Pei Feng Tan, Annika Tillmann, Susan J Murby, Amin Rostami-Hodjegan, Daniel Scotcher

Mol Pharm· September 2024

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Facing the Facts of Altered Plasma Protein Binding: Do Current Models Correctly Predict Changes in Fraction Unbound in Special Populations?
Jokha Al-Qassabi, Shawn Pei Feng Tan, Patcharapan Phonboon, Aleksandra Galetin, Amin Rostami-Hodjegan, Daniel Scotcher

J Pharm Sci· June 2024

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Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease.
Eman El-Khateeb, Rajkumar Chinnadurai, Jokha Al Qassabi, Daniel Scotcher, Adam S Darwich

Ther Drug Monit· December 2023

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Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease.
Shawn Pei Feng Tan, Marie-Emilie Willemin, Jan Snoeys, Hong Shen, Amin Rostami-Hodjegan, Daniel Scotcher

Clin Pharmacol Ther· December 2023

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Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation.
Nihan Izat, Jayaprakasam Bolleddula, Armina Abbasi, Lionel Cheruzel, Robert S Jones, Daniel Scotcher

Drug Metab Dispos· December 2023

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Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling.
Jill Barber, Zubida M Al-Majdoub, Narciso Couto, Martyn Howard, Yasmine Elmorsi, Daniel Scotcher

Eur J Pharm Sci· March 2023

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Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats.
Nicola Melillo, Daniel Scotcher, J Gerry Kenna, Claudia Green, Catherine D G Hines

Pharmaceutics· March 2023

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Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically-Based Pharmacokinetic Modeling and Dose Adjustment.
Shawn Pei Feng Tan, Daniel Scotcher, Amin Rostami-Hodjegan, Aleksandra Galetin

Clin Pharmacol Ther· September 2022

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Coproporphyrin I as an Endogenous Biomarker to Detect Reduced OATP1B Activity and Shift in Elimination Route in Chronic Kidney Disease.
Hiroyuki Takita, Daniel Scotcher, Xiaoyan Chu, Ka Lai Yee, Kayode Ogungbenro

Clin Pharmacol Ther· September 2022

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Correction to: Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug-Drug Interactions.
Marie-Emilie Willemin, Thomas K Van Der Made, Ils Pijpers, Lieve Dillen, Annett Kunze, Daniel Scotcher

Clin Pharmacokinet· March 2022

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PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid Intake.
Daniel Scotcher, Aleksandra Galetin

AAPS J· December 2021

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Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics.
Zubida M Al-Majdoub, Daniel Scotcher, Brahim Achour, Jill Barber, Aleksandra Galetin

Clin Pharmacol Ther· November 2021

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Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug-Drug Interactions.
Marie-Emilie Willemin, Thomas K Van Der Made, Ils Pijpers, Lieve Dillen, Annett Kunze, Daniel Scotcher

Clin Pharmacokinet· September 2021

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Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats.
Daniel Scotcher, Nicola Melillo, Sirisha Tadimalla, Adam S Darwich, Sabina Ziemian

Mol Pharm· August 2021

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Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis.
Areti-Maria Vasilogianni, Brahim Achour, Daniel Scotcher, Sheila Annie Peters, Zubida M Al-Majdoub

Drug Metab Dispos· July 2021

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Scaling Factors for Clearance in Adult Liver Cirrhosis.
Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M Al-Majdoub, Varinder Athwal

Drug Metab Dispos· December 2020

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Physiologically-Based Pharmacokinetic Modelling of Creatinine-Drug Interactions in the Chronic Kidney Disease Population.
Hiroyuki Takita, Daniel Scotcher, Rajkumar Chinnadurai, Philip A Kalra, Aleksandra Galetin

CPT Pharmacometrics Syst Pharmacol· December 2020

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Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin.
Zubida M Al-Majdoub, Brahim Achour, Narciso Couto, Martyn Howard, Yasmine Elmorsi, Daniel Scotcher

FEBS Lett· December 2020

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A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations.
Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang

CPT Pharmacometrics Syst Pharmacol· June 2020

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