Publications by authors named "Danny Huang"

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Short, Enantioselective Total Synthesis of (+)-Ineleganolide.
Kuan Yu, Aikaterini Gorou, Danny Huang, Thomas J Maimone

J Am Chem Soc· December 2025

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Technology and Dementia Preconference.
Rameen Mahmood, Danny Yuxing Huang

Alzheimers Dement· December 2025

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Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue.
Mark A Nakasone, Lori Buetow, Mads Gabrielsen, Syed F Ahmed, Karolina A Majorek, Danny T Huang

Life Sci Alliance· October 2025

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Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in wild-type and mutant cancer cells.
Sean F Cooke, Thomas A Wright, Gillian Lappin, Elka Kyurkchieva, Yuan Yan Sin, Danny T Huang

Mol Ther Oncol· September 2025

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Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.
Syed Feroj Ahmed, Jayanthi Anand, Wei Zhang, Lori Buetow, Loveena Rishi, Danny T Huang

Mol Ther· August 2025

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Grafted Coiled-Coil Peptides as Multivalent Scaffolds for Protein Recognition.
Amanda M Acevedo-Jake, Bram Mylemans, Danielle F Kay, Peiyu Zhang, Boguslawa Korona, Danny T Huang

ACS Chem Biol· June 2025

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Insights into non-proteinaceous ubiquitination.
Emily L Dearlove, Danny T Huang

Biochem Soc Trans· April 2025

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Raman active diyne-girder conformationally constrained p53 stapled peptides bind to MDM2 for visualisation without fluorophores.
Danielle C Morgan, Laura McDougall, Astrid Knuhtsen, Lori Buetow, Craig F Steven, Danny T Huang

RSC Chem Biol· March 2025

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DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids.
Emily L Dearlove, Chatrin Chatrin, Lori Buetow, Syed F Ahmed, Tobias Schmidt, Danny T Huang

Elife· October 2024

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Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated monocyte activation.
Jonathan Bohlen, Ivan Bagarić, Taja Vatovec, Masato Ogishi, Syed F Ahmed, Danny T Huang

J Clin Invest· October 2024

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AlphaFold Ensemble Competition Screens Enable Peptide Binder Design with Single-Residue Sensitivity.
Pernille Vosbein, Paula Paredes Vergara, Danny T Huang, Andrew R Thomson

ACS Chem Biol· October 2024

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An engineered ubiquitin binding coiled coil peptide.
Pernille Vosbein, Paula Paredes Vergara, Danny T Huang, Andrew R Thomson

Chem Sci· September 2024

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Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response.
Esmee Vringer, Rosalie Heilig, Joel S Riley, Annabel Black, Catherine Cloix, Danny T Huang

EMBO J· March 2024

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PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
Hongxia Chen, Yunpeng Bai, Michihiro Kobayashi, Shiyu Xiao, Sergio Barajas, Danny T Huang

Mol Cancer Res· January 2024

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PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer.
Konstantina Nikolatou, Emma Sandilands, Alvaro Román-Fernández, Erin M Cumming, Eva Freckmann, Danny T Huang

EMBO J· September 2023

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Large Growth Deformations of Thin Tissue Using Solid-Shells.
Danny Huang, Ian Stavness

IEEE Trans Vis Comput Graph· March 2023

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Hepatic glutamine synthetase controls N-methylglutamine in homeostasis and cancer.
Victor H Villar, Maria Francesca Allega, Ruhi Deshmukh, Tobias Ackermann, Mark A Nakasone, Danny T Huang

Nat Chem Biol· March 2023

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eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
Tobias Schmidt, Adrianna Dabrowska, Joseph A Waldron, Kelly Hodge, Grigorios Koulouras, Danny Huang

Nucleic Acids Res· February 2023

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PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Hongxia Chen, Yunpeng Bai, Michihiro Kobayashi, Shiyu Xiao, Wenjie Cai, Danny T Huang

Blood· January 2023

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Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function.
Dominika Kowalczyk, Mark A Nakasone, Brian O Smith, Danny T Huang

Life Sci Alliance· August 2022

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Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension.
Mark A Nakasone, Karolina A Majorek, Mads Gabrielsen, Gary J Sibbet, Brian O Smith, Danny T Huang

Nat Chem Biol· April 2022

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Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.
Timothy J Humpton, Koji Nomura, Julia Weber, Helge M Magnussen, Andreas K Hock, Danny T Huang

Genes Dev· July 2021

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Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
Helge M Magnussen, Danny T Huang

J Mol Biol· March 2021

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E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.
Syed Feroj Ahmed, Lori Buetow, Mads Gabrielsen, Sergio Lilla, Gary J Sibbet, Danny T Huang

Oncogene· March 2021

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Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.
Timothy J Humpton, Koji Nomura, Julia Weber, Helge M Magnussen, Andreas K Hock, Danny T Huang

Genes Dev· January 2021

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