Publications by authors named "Danny Legge"

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Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes.
Emma Hazelwood, Daffodil M Canson, Benedita Deslandes, Xuemin Wang, Pik Fang Kho, Danny Legge

Nat Commun· May 2025

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Identifying targetable metabolic dependencies across colorectal cancer progression.
Danny N Legge, Tracey J Collard, Ewelina Stanko, Ashley J Hoskin, Amy K Holt

Mol Metab· December 2024

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Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.
Jodie Bojko, Madhu Kollareddy, Marianna Szemes, Jacob Bellamy, Evon Poon, Danny Legge

Cancer Lett· November 2024

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Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetes.
Caroline J Bull, Emma Hazelwood, Danny N Legge, Laura J Corbin, Tom G Richardson

EBioMedicine· February 2024

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Identifying metabolic features of colorectal cancer liability using Mendelian randomization.
Caroline Bull, Emma Hazelwood, Joshua A Bell, Vanessa Tan, Andrei-Emil Constantinescu, Danny Legge

Elife· December 2023

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Identifying metabolic features of colorectal cancer liability using Mendelian randomization.
Caroline J Bull, Emma Hazelwood, Joshua A Bell, Vanessa Y Tan, Andrei-Emil Constantinescu, Danny N Legge

medRxiv· November 2023

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Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition.
Amy K Holt, Arafath K Najumudeen, Tracey J Collard, Hao Li, Laura M Millett, Danny N Legge

Cancer Metab· October 2023

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In-silico and in-vitro morphometric analysis of intestinal organoids.
Sandra Montes-Olivas, Danny Legge, Abbie Lund, Alexander G Fletcher, Ann C Williams

PLoS Comput Biol· August 2023

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Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer.
Ashley J Hoskin, Amy K Holt, Danny N Legge, Tracey J Collard, Ann C Williams

Explor Target Antitumor Ther· August 2023

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Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization.
Mark Gormley, Tom Dudding, Steven J Thomas, Jessica Tyrrell, Andrew R Ness, Danny Legge

Elife· April 2023

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The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.
Danny Legge, Ling Li, Whei Moriarty, David Lee, Marianna Szemes

Mol Oncol· February 2022

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5-Aminosalicylic acid inhibits stem cell function in human adenoma-derived cells: implications for chemoprophylaxis in colorectal tumorigenesis.
Steven William Dixon, Tracey Jane Collard, Eleanor May Harrisdotter Mortensson, Danny Nigel Legge, Adam Christian Chambers

Br J Cancer· June 2021

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.
Mark Gormley, James Yarmolinsky, Tom Dudding, Kimberley Burrows, Richard M Martin, Danny Legge

PLoS Genet· April 2021

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The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis.
Danny N Legge, Adam C Chambers, Christopher T Parker, Penny Timms, Tracey J Collard

Carcinogenesis· May 2020

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BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells.
Danny N Legge, Alex P Shephard, Tracey J Collard, Alexander Greenhough, Adam C Chambers

Dis Model Mech· March 2019

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