Publications by authors named "Dariusz Pytel"

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The Proteostasis Network in Proteinopathies: Mechanisms and Interconnections.
Dariusz Pytel, Jody Fromm Longo

Am J Pathol· August 2025

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Unveiling the Intricate Link Between Anaerobe Niche and Alzheimer Disease Pathogenesis.
NyEmma Drakes, Galina Kondrikova, Dariusz Pytel, Eric D Hamlett

J Infect Dis· September 2024

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Evaluation of the LDN-0060609 PERK Inhibitor as a Selective Treatment for Primary Open-Angle Glaucoma: An In Vitro Study on Human Retinal Astrocytes.
Wioletta Rozpędek-Kamińska, Grzegorz Galita, Kamil Saramowicz, Zuzanna Granek, Julia Barczuk, Dariusz Pytel

Int J Mol Sci· January 2024

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The diversification of SARS-CoV-2 Omicron variants and evaluation of their detection with molecular and rapid antigen assays.
Mark Anderson, Vera Holzmayer, Barbara Harris, Austin Hodges, Ana Olivo, Dariusz Pytel

J Clin Virol· September 2023

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Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation.
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J Nathaniel Diehl, Dariusz Pytel

Nat Commun· November 2022

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Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function.
Paramita Chakraborty, Rasesh Y Parikh, Seungho Choi, Danh Tran, Monika Gooz, Dariusz Pytel

Cancer Res· May 2022

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Small-molecule inhibitors of the PERK-mediated Unfolded Protein Response signaling pathway in targeted therapy for colorectal cancer.
Wioletta Rozpedek-Kaminska, Danuta Piotrzkowska, Grzegorz Galita, Dariusz Pytel, Ewa Kucharska

Pol Przegl Chir· March 2022

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The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment.
Wioletta Rozpędek-Kamińska, Grzegorz Galita, Natalia Siwecka, Steven L Carroll, John Alan Diehl, Dariusz Pytel

Int J Mol Sci· April 2021

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The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate.
Natalia Siwecka, Wioletta Rozpędek-Kamińska, Adam Wawrzynkiewicz, Dariusz Pytel, J Alan Diehl

Biomedicines· February 2021

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Use of Small-molecule Inhibitory Compound of PERK-dependent Signaling Pathway as a Promising Target-based Therapy for Colorectal Cancer.
Wioletta Rozpędek, Dariusz Pytel, Adam Wawrzynkiewicz, Natalia Siwecka, Adam Dziki

Curr Cancer Drug Targets· September 2020

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Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.
Wioletta Rozpędek, Dariusz Pytel, Tomasz Popławski, Anna Walczak, Kinga Gradzik

Curr Alzheimer Res· June 2020

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The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
Wioletta Rozpędek-Kamińska, Natalia Siwecka, Adam Wawrzynkiewicz, Radosław Wojtczak, Dariusz Pytel

Int J Mol Sci· March 2020

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Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases.
Tomasz Poplawski, Dariusz Pytel, Jaroslaw Dziadek, Ireneusz Majsterek

Oxid Med Cell Longev· January 2020

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Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis.
Natalia Siwecka, Wioletta Rozpędek, Dariusz Pytel, Adam Wawrzynkiewicz, Adam Dziki

Int J Mol Sci· September 2019

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Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment.
Wioletta Rozpędek, Dariusz Pytel, Alicja Nowak-Zduńczyk, Dawid Lewko, Radosław Wojtczak

Curr Med Chem· June 2019

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[Potential therapeutic application of PERK inhibitors].
Justyna Basak, Wioletta Rozpędek, Dariusz Pytel, Ireneusz Majsterek

Postepy Biochem· June 2019

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Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells.
Tomasz Kowalczyk, Przemysław Sitarek, Ewa Skała, Monika Toma, Marzena Wielanek, Dariusz Pytel

Cytotechnology· February 2019

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[Niskocząsteczkowe inhibitory szlaku adaptacyjnej odpowiedzi na stres zależnego od kinazy PERK jako nowatorska strategia terapeutyczna w leczeniu choroby Alzheimera].
Wioletta Rozpędek, Dariusz Pytel, J Alan Diehl, Ireneusz Majsterek

Pol Merkur Lekarski· January 2019

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Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract.
Ewa Skała, Tomasz Kowalczyk, Monika Toma, Janusz Szemraj, Maciej Radek, Dariusz Pytel

Mol Cell Biochem· August 2018

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Nucleotide Excision Repair Capacity and XPC and XPD Gene Polymorphism Modulate Colorectal Cancer Risk.
Bartosz Mucha, Dariusz Pytel, Lukasz Markiewicz, Magda Cuchra, Izabela Szymczak

Clin Colorectal Cancer· June 2018

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Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.
Wioletta Rozpędek, Dariusz Pytel, Łukasz Dziki, Alicja Nowak, Adam Dziki

Pol Przegl Chir· June 2017

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The Essential Oils of Hairy Roots and Roots of Soil-Grown Plants: Chemical Composition and Antimicrobial, Anti-Inflammatory, and Antioxidant Activities.
Ewa Skała, Patrícia Rijo, Catarina Garcia, Przemysław Sitarek, Danuta Kalemba, Dariusz Pytel

Oxid Med Cell Longev· March 2017

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Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of L. and Their Chemical Composition.
Przemysław Sitarek, Patricia Rijo, Catarina Garcia, Ewa Skała, Danuta Kalemba, Dariusz Pytel

Oxid Med Cell Longev· March 2017

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The role of base excision repair in pathogenesis of breast cancer in the Polish population.
Magda Cuchra, Bartosz Mucha, Lukasz Markiewicz, Karolina Przybylowska-Sygut, Dariusz Pytel

Mol Carcinog· December 2016

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PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.
Dariusz Pytel, Yan Gao, Katarzyna Mackiewicz, Yuliya V Katlinskaya, Kirk A Staschke

PLoS Genet· December 2016

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