Publications by authors named "Darlene Dai"

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Early-preschool wheeze trajectories are predominantly nonallergic with distinct biologic and microbiome traits.
Zihang Lu, Charisse Petersen, Ruixue Dai, Myrtha E Reyna, Mojtaba Ahmadiankalati, Darlene L Y Dai

J Allergy Clin Immunol· December 2025

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Gene-by-environment interactions modulate the infant gut microbiota in asthma and atopy.
Sara A Stickley, Zhi Yi Fang, Amirthagowri Ambalavanan, Yang Zhang, Amanda M Zacharias, Darlene Dai

J Allergy Clin Immunol· August 2025

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Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study.
Maria V Medeleanu, Myrtha E Reyna, Darlene L Y Dai, Geoffrey L Winsor, Fiona S L Brinkman

Front Allergy· January 2025

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Reduce, reinforce, and replenish: safeguarding the early-life microbiota to reduce intergenerational health disparities.
Darlene L Y Dai, Charisse Petersen, Stuart E Turvey

Front Public Health· November 2024

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Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development.
Liat Shenhav, Kelsey Fehr, Myrtha E Reyna, Charisse Petersen, Darlene L Y Dai, Ruixue Dai

Cell· September 2024

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Antibiotics taken within the first year of life are linked to infant gut microbiome disruption and elevated atopic dermatitis risk.
Courtney Hoskinson, Maria V Medeleanu, Myrtha E Reyna, Darlene L Y Dai, Biswajit Chowdhury

J Allergy Clin Immunol· July 2024

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Early prediction of pediatric asthma in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort using machine learning.
Ping He, Theo J Moraes, Darlene Dai, Myrtha E Reyna-Vargas, Ruixue Dai

Pediatr Res· June 2024

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Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease.
Courtney Hoskinson, Darlene L Y Dai, Kate L Del Bel, Allan B Becker, Theo J Moraes

Nat Commun· August 2023

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Breastfeeding enrichment of B. longum subsp. infantis mitigates the effect of antibiotics on the microbiota and childhood asthma risk.
Darlene L Y Dai, Charisse Petersen, Courtney Hoskinson, Kate L Del Bel, Allan B Becker

Med· February 2023

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Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation.
Catherine M Biggs, Anna Cordeiro-Santanach, Sergey V Prykhozhij, Adam P Deveau, Yi Lin, Darlene Dai

JCI Insight· December 2022

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Longitudinal body mass index trajectories at preschool age: children with rapid growth have differential composition of the gut microbiota in the first year of life.
Myrtha E Reyna, Charisse Petersen, Darlene L Y Dai, Ruixue Dai, Allan B Becker

Int J Obes (Lond)· July 2022

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Inborn Errors of Immunity Associated With Type 2 Inflammation in the USIDNET Registry.
Kelsey L Smith, Darlene Dai, Bhavi P Modi, Rahnuma Sara, Elizabeth Garabedian

Front Immunol· May 2022

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Early-life cytomegalovirus infection is associated with gut microbiota perturbations and increased risk of atopy.
Hind Sbihi, Karen E Simmons, Malcolm R Sears, Theo J Moraes, Allan B Becker, Darlene L Y Dai

Pediatr Allergy Immunol· January 2022

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Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes.
Rozlyn C T Boutin, Hind Sbihi, Ryan J McLaughlin, Aria S Hahn, Kishori M Konwar, Darlene Dai

mBio· June 2021

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A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization.
Charisse Petersen, Darlene L Y Dai, Rozlyn C T Boutin, Hind Sbihi, Malcolm R Sears

Cell Rep Med· May 2021

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Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies.
David M Patrick, Hind Sbihi, Darlene L Y Dai, Abdullah Al Mamun, Drona Rasali

Lancet Respir Med· November 2020

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Clinical Utility of a Genomic Classifier in Men Undergoing Radical Prostatectomy: The PRO-IMPACT Trial.
John L Gore, Marguerite du Plessis, Jingbin Zhang, Darlene Dai, Darby J S Thompson

Pract Radiat Oncol· October 2020

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Mining the infant gut microbiota for therapeutic targets against atopic disease.
Rozlyn C T Boutin, Hind Sbihi, Melissa Dsouza, Raunaq Malhotra, Charisse Petersen, Darlene Dai

Allergy· August 2020

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HEARTBiT: A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients.
Casey P Shannon, Zsuzsanna Hollander, Darlene L Y Dai, Virginia Chen, Sara Assadian

Can J Cardiol· August 2020

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Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization.
Alissa Cait, Erick Cardenas, Pedro A Dimitriu, Nelly Amenyogbe, Darlene Dai

J Allergy Clin Immunol· December 2019

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Multiplexed LC-ESI-MRM-MS-based Assay for Identification of Coronary Artery Disease Biomarkers in Human Plasma.
Mohammad A Anwar, Darlene Liying Dai, Janet Wilson-McManus, Derek Smith, Gordon A Francis

Proteomics Clin Appl· July 2019

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Ensembling Electrical and Proteogenomics Biomarkers for Improved Prediction of Cardiac-Related 3-Month Hospitalizations: A Pilot Study.
Amrit Singh, Darlene L Y Dai, Kostas Ioannou, Virginia Chen, Karen K Lam

Can J Cardiol· April 2019

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Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease.
Zhicheng Jin, Timothy S Collier, Darlene L Y Dai, Virginia Chen, Zsuzsanna Hollander

Clin Chem· February 2019

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Performance of a Prostate Cancer Genomic Classifier in Predicting Metastasis in Men with Prostate-specific Antigen Persistence Postprostatectomy.
Daniel E Spratt, Darlene L Y Dai, Robert B Den, Patricia Troncoso, Kasra Yousefi

Eur Urol· July 2018

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Multiple reaction monitoring mass spectrometry to identify novel plasma protein biomarkers of treatment response in cystic fibrosis pulmonary exacerbations.
James M Roberts, Darlene L Y Dai, Zsuzsanna Hollander, Raymond T Ng, Scott J Tebbutt

J Cyst Fibros· May 2018

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