Publications by authors named "David A Harrison"

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Hospital mortality, withdrawal of life-sustaining therapy decisions and early secondary brain insults for critically ill traumatic brain injury patients in England, Wales and Northern Ireland (2009-2024): an observational cohort study.
Xavier Chapalain, Olivier Huet, Kathryn M Rowan, Paul R Mouncey, Olivier Langeron, David A Harrison

Lancet Reg Health Eur· February 2026

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Relationship Between Phenotyping and Individualized Absolute Risk Differences in Sepsis: A Secondary Analysis of Two Approaches in Two Multicenter Trials.
Victor B Talisa, Sachin P Yende, Derek C Angus, Rinaldo Bellomo, Chung-Chou H Chang, David A Harrison

Crit Care Explor· October 2025

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Non-invasive respiratory support in paediatric critical care: protocol for a cohort study emulating the FIRST-line support for Assistance in Breathing in Children (FIRST-ABC) step-up randomised clinical trial using routinely collected data from the Paediatric Intensive Care Audit Network (PICANet) database.
Elisa Giallongo, Orlagh Carroll, Padmanabhan Ramnarayan, Rebecca Mitting, Sarah E Seaton, David A Harrison

BMJ Open· October 2025

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Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients: The UK-ROX Randomized Clinical Trial.
Daniel S Martin, Doug W Gould, Tasnin Shahid, James C Doidge, Alex Cowden, David A Harrison

JAMA· August 2025

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Early weaning from oxygen therapy in African children with severe pneumonia.
Kathryn Maitland, Elisa Giallongo, Mainga Hamaluba, Florence Alaroker, Robert O Opoka, David A Harrison

BMC Med· July 2025

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Corticosteroids for adult patients hospitalised with non-viral community-acquired pneumonia: a systematic review and meta-analysis.
Tyler Pitre, Ellen Pauley, Dipayan Chaudhuri, Rohit Saha, Kristina E Rudd, David A Harrison

Intensive Care Med· May 2025

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Severity of Impaired Oxygenation and Conservative Oxygenation Targets in Mechanically Ventilated Children: A Post Hoc Subgroup Analysis of the Oxy-PICU Trial of Conservative Oxygenation.
Samiran Ray, Martin Wiegand, Doug W Gould, David A Harrison, Paul R Mouncey

Pediatr Crit Care Med· April 2025

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Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials.
Faraaz Ali Shah, Victor B Talisa, Chung-Chou H Chang, Sofia Triantafyllou, Lu Tang, David A Harrison

Crit Care Med· January 2025

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Blood Pressure Targets for Adults with Vasodilatory Shock - An Individual Patient Data Meta-Analysis.
Federico Angriman, Neda Momenzade, Neill K J Adhikari, Paul R Mouncey, Pierre Asfar, David A Harrison

NEJM Evid· January 2025

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Longer-term survival, quality of life, and cost-effectiveness of conservative versus liberal oxygenation targets in critically ill children: a pre-specified analysis from Oxy-PICU, a multicentre, open, parallel-group, randomised controlled trial.
Silvia Moler-Zapata, Mark J Peters, Doug W Gould, Elisa Giallongo, Marzena Orzol, David A Harrison

Lancet Child Adolesc Health· January 2025

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Cost-effectiveness of high flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care.
Zia Sadique, Silvia Moler Zapata, Richard Grieve, Alvin Richards-Belle, Izabella Lawson, David A Harrison

Crit Care· November 2024

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Ethnicity and Observed Oxygen Saturations, Fraction of Inspired Oxygen, and Clinical Outcomes: A Post-Hoc Analysis of the Oxy-PICU Trial of Conservative Oxygenation.
Gareth A L Jones, Martin Wiegand, Samiran Ray, Doug W Gould, Rachel Agbeko, David A Harrison

Pediatr Crit Care Med· October 2024

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Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK.
Joshua A Bell, David Carslake, Amanda Hughes, Kate Tilling, James W Dodd, David A Harrison

BMC Med· September 2024

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Oxygenation targets in critically ill children: the Oxy-PICU trial - Authors' reply.
Mark J Peters, Doug W Gould, David A Harrison, Paul R Mouncey,

Lancet· August 2024

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Protocol for a Randomized Controlled Trial to Evaluate a Permissive Blood Pressure Target Versus Usual Care in Critically Ill Children with Hypotension (PRESSURE).
Robert Darnell, Alanna Brown, Emma Laing, Julia Edwards, David A Harrison

Pediatr Crit Care Med· July 2024

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Nutritional supplementation in children with severe pneumonia in Uganda and Kenya (COAST-Nutrition): a phase 2 randomised controlled trial.
Sarah Kiguli, Peter Olupot-Olupot, Mainga Hamaluba, Elisa Giallongo, Karen Thomas, David A Harrison

EClinicalMedicine· June 2024

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Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care: Protocol for the UK-ROX trial.
Daniel S Martin, Tasnin Shahid, Doug W Gould, Alvin Richards-Belle, James C Doidge, David A Harrison

J Intensive Care Soc· May 2024

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Temporal Trends in Mortality of Critically Ill Patients with Sepsis in the United Kingdom, 1988-2019.
Hallie C Prescott, David A Harrison, Kathryn M Rowan, Manu Shankar-Hari, Hannah Wunsch

Am J Respir Crit Care Med· March 2024

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Use of selective gut decontamination in critically ill children: PICnIC a pilot RCT and mixed-methods study.
Alanna Brown, Paloma Ferrando-Vivas, Mariana Popa, Gema Milla de la Fuente, John Pappachan, David A Harrison

Health Technol Assess· February 2024

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Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial.
Mark J Peters, Doug W Gould, Samiran Ray, Karen Thomas, Irene Chang, David A Harrison

Lancet· January 2024

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Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.
Alice-Maria Toader, Marion K Campbell, Jennifer K Quint, Michael Robling, Matthew R Sydes, David A Harrison

Trials· January 2024

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Simvastatin in Critically Ill Patients with Covid-19.

N Engl J Med· December 2023

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The effect of conservative oxygen therapy on mortality in adult critically ill patients: A systematic review and meta-analysis of randomised controlled trials.
Daniel S Martin, Helen T Mckenna, Kathryn M Rowan, Doug W Gould, Paul R Mouncey, David A Harrison

J Intensive Care Soc· November 2023

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Publisher Correction: The effect of blood pressure on mortality following out‑of‑hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database.
Peter J McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A Harrison

Crit Care· May 2023

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Timing and burden of persistent critical illnessin UK intensive care units: An observational cohort study.
David A Harrison, Ben C Creagh-Brown, Kathryn M Rowan

J Intensive Care Soc· May 2023

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