Publications by authors named "David A Hutton"

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Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: translational evidence of prevention with senolytic treatment.
Ravinandan Venkatasubramanian, Sophia A Mahoney, David A Hutton, Nicholas S VanDongen, Vienna E Brunt

Am J Physiol Heart Circ Physiol· December 2025

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Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress.
Ravinandan Venkatasubramanian, Mary A Darrah, Sophia A Mahoney, David A Hutton, Grace S Maurer

Hypertension· October 2025

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Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress.
Ravinandan Venkatasubramanian, Mary A Darrah, Sophia A Mahoney, David A Hutton, Grace S Maurer

bioRxiv· May 2025

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Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.
Sophia A Mahoney, Ravinandan Venkatasubramanian, Mary A Darrah, Katelyn R Ludwig, Nicholas S VanDongen, David A Hutton

Aging Cell· March 2024

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Protective effects of apigenin on the brain transcriptome with aging.
Alyssa N Cavalier, Zachary S Clayton, Devin Wahl, David A Hutton, Cali M McEntee

Mech Ageing Dev· February 2024

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Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment.
Zachary S Clayton, Matthew J Rossman, Sophia A Mahoney, Ravinandan Venkatasubramanian, Grace S Maurer, David A Hutton

Hypertension· October 2023

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Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice.
Abigail G Casso, Nicholas S VanDongen, Rachel A Gioscia-Ryan, Zachary S Clayton, Nathan T Greenberg, David A Hutton

J Physiol· November 2022

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Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation.
Zachary S Clayton, Rachel A Gioscia-Ryan, Jamie N Justice, Kara L Lubieniecki, David A Hutton

Exp Gerontol· January 2022

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Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin.
Alyssa N Cavalier, Zachary S Clayton, David A Hutton, Devin Wahl, Daniel S Lark

Exp Gerontol· September 2021

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Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.
Vienna E Brunt, Abigail G Casso, Rachel A Gioscia-Ryan, Zachary J Sapinsley, Brian P Ziemba, David A Hutton

Hypertension· August 2021

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Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging.
Zachary S Clayton, David A Hutton, Vienna E Brunt, Nicholas S VanDongen, Brian P Ziemba

Am J Physiol Heart Circ Physiol· July 2021

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Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging.
Zachary S Clayton, David A Hutton, Sophia A Mahoney, Douglas R Seals

Aging Cancer· June 2021

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Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin.
Zachary S Clayton, Vienna E Brunt, David A Hutton, Abigail G Casso, Brian P Ziemba

Hypertension· May 2021

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Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice.
Rachel A Gioscia-Ryan, Zachary S Clayton, Melanie C Zigler, James J Richey, Lauren M Cuevas, David A Hutton

J Physiol· February 2021

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Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment.
Zachary S Clayton, Vienna E Brunt, David A Hutton, Nicholas S VanDongen, Angelo D'Alessandro

JACC CardioOncol· September 2020

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Cerebrovascular reactivity: a new frontier for measuring cognitive health in models of accelerated ageing?
David A Hutton, Alyssa N Cavalier, Zachary S Clayton

J Physiol· August 2020

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Physical activity-related suppression of cancer growth: is a transient increase in cytokine production required for tumour angiogenesis?
David A Hutton, Zachary S Clayton

J Physiol· August 2019

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Major secretory mucin expression in chronic sinusitis.
Mahmoud S Ali, David A Hutton, Janet A Wilson, Jeffrey P Pearson

Otolaryngol Head Neck Surg· September 2005

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