Publications by authors named "David A Jacobson"

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Glycolytic activation of β-cell Na/K-ATPases containing β1-subunits accelerates Na extrusion, prolonging the duration of Ca oscillations but decreasing insulin secretion.
Matthew T Dickerson, Prasanna K Dadi, Reagan P McDevitt, Jordyn R Dobson, Soma Behera, David A Jacobson

Mol Metab· December 2025

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Sarco/Endoplasmic Reticulum Ca ATPase Activation Shifts Cardiac Fuel Preference Without Impairing Cardiac Function in Obese Mice.
Deveena R Banerjee, Clinton M Hasenour, Mohsin Rahim, Tomasz K Bednarski, Amanda C Doran, David A Jacobson

J Am Heart Assoc· December 2025

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CHD3 and CHD4 coordinate gene expression programs to maintain β-cell function and identity .
Sukrati Kanojia, Avinil Das Sharma, Rajani M George, Abigail G Taylor, Wenting Wu, David A Jacobson

Res Sq· November 2025

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Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell Identity.
Anna B Osipovich, Matthew T Dickerson, Jean-Philippe Cartailler, Shristi Shrestha, Nicole M Wright, David A Jacobson

Diabetes· September 2025

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Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors.
Monica E Brown, Verda E Miranda, Simone Nevills, Ruiying Hu, Prasanna K Dadi, David A Jacobson

Nat Commun· July 2025

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Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid.
Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew T Dickerson, David A Jacobson

Diabetes· May 2025

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Atf4 protects islet β-cell identity and function under acute glucose-induced stress but promotes β-cell failure in the presence of free fatty acid.
Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Prasanna Dadi, David A Jacobson

bioRxiv· July 2024

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Purinergic Ca Signaling as a Novel Mechanism of Drug Tolerance in BRAF-Mutant Melanoma.
Philip E Stauffer, Jordon Brinkley, David A Jacobson, Vito Quaranta, Darren R Tyson

Cancers (Basel)· June 2024

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The MODY-associated L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults.
Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, David A Jacobson

Elife· May 2024

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Disrupted Endoplasmic Reticulum Ca Handling: A Harβinger of β-Cell Failure.
Jordyn R Dobson, David A Jacobson

Biology (Basel)· May 2024

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The MODY-associated L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults.
Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, David A Jacobson

bioRxiv· February 2024

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TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet.
Sarah M Graff, Arya Y Nakhe, Prasanna K Dadi, Matthew T Dickerson, Jordyn R Dobson, David A Jacobson

Cell Rep· January 2024

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IPRs puff along: A SNAPpy dance with IP and Ca.
Arya Y Nakhe, David A Jacobson

J Biol Chem· March 2023

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G protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na/K ATPase activation.
Matthew T Dickerson, Prasanna K Dadi, Karolina E Zaborska, Arya Y Nakhe, Charles M Schaub, David A Jacobson

Nat Commun· October 2022

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Liraglutide increases islet Ca oscillation frequency and insulin secretion by activating hyperpolarization-activated cyclic nucleotide-gated channels.
Karolina E Zaborska, Kelli L Jordan, Ariel S Thorson, Prasanna K Dadi, Charles M Schaub, David A Jacobson

Diabetes Obes Metab· September 2022

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Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function.
Rebecca Cheung, Grazia Pizza, Pauline Chabosseau, Delphine Rolando, Alejandra Tomas, David A Jacobson

Diabetes· July 2022

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Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells.
Mohsin Rahim, Arya Y Nakhe, Deveena R Banerjee, Emily M Overway, Karin J Bosma, David A Jacobson

J Biol Chem· April 2022

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Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function.
Taiyi Kuo, Wen Du, Yasutaka Miyachi, Prasanna K Dadi, David A Jacobson

Mol Metab· November 2021

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Channeling β-cell Maturity: KATP Surface Localization Imparts Glucose Sensing.
Matthew Thomas Dickerson, David Aaron Jacobson

Endocrinology· November 2021

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Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.
Emily M Walker, Jeeyeon Cha, Xin Tong, Min Guo, Jin-Hua Liu, David A Jacobson

Cell Rep· October 2021

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TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation.
Molly K Altman, Charles M Schaub, Prasanna K Dadi, Matthew T Dickerson, Karolina E Zaborska, David A Jacobson

Development· August 2021

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A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young.
Sarah M Graff, Stephanie R Johnson, Paul J Leo, Prasanna K Dadi, Matthew T Dickerson, David A Jacobson

JCI Insight· July 2021

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Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation.
Tiziana Sanavia, Chen Huang, Elisabetta Manduchi, Yanwen Xu, Prasanna K Dadi, David A Jacobson

Front Cell Dev Biol· May 2021

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KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
James D West, Eric D Austin, Elise M Rizzi, Ling Yan, Harikrishna Tanjore, David A Jacobson

Int J Mol Sci· May 2021

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Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.
S Neda Mousavy Gharavy, Bryn M Owen, Steven J Millership, Pauline Chabosseau, Grazia Pizza, David A Jacobson

Diabetologia· April 2021

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