Publications by authors named "David Ackerley"

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A rapid combinatorial assembly method for gene cluster characterisation illuminates glidobactin biosynthesis.
Mark J Calcott, Jonas Kröger, David F Ackerley

Synth Syst Biotechnol· March 2026

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Optimized chemogenetic ablation and regeneration of enteric nervous system neurons in zebrafish.
Mujahid Ali Shah, Katherine K Moran, Helen Rueckert, Abigail V Sharrock, David F Ackerley

bioRxiv· December 2025

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Novel TdsD nitroreductase: characterization of kinetics and substrate specificity.
Benjaminas Valiauga, Dovydė Žulpaitė, Abigail V Sharrock, David F Ackerley, Narimantas Čėnas

Biotechnol Lett· September 2025

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Purpuramine R, a New Bromotyrosine Isolated from cf. Collected in the Kingdom of Tonga.
Jennie L Ramirez-Garcia, Hannah Lee-Harwood, David Ackerley, Michelle Kelly, S Vailala Matoto

Mar Drugs· April 2025

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Heterologous Expression of Epoxomicin in .
Sarah R Messenger, David F Ackerley, Mark J Calcott

ACS Synth Biol· September 2024

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A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.
Kevin Emmerich, John Hageter, Thanh Hoang, Pin Lyu, Abigail V Sharrock, David F Ackerley

Development· August 2024

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Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623.
Abigail V Sharrock, Jeff S Mumm, Elsie M Williams, Narimantas Čėnas, Jeff B Smaill, David F Ackerley

Int J Mol Sci· June 2024

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The Catalysis Mechanism of Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies.
Benjaminas Valiauga, Gintautas Bagdžiūnas, Abigail V Sharrock, David F Ackerley, Narimantas Čėnas

Int J Mol Sci· April 2024

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Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides.
Sarah R Messenger, Edward M R McGuinniety, Luke J Stevenson, Jeremy G Owen, Gregory L Challis, David F Ackerley

Nat Chem Biol· February 2024

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A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Michelle H Rich, Abigail V Sharrock, Timothy S Mulligan, Frazer Matthews, Alistair S Brown, David F Ackerley

Cell Chem Biol· December 2023

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Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine.
Ruth Pay, Abigail V Sharrock, Riley Elder, Alaigne Maré, Joe Bracegirdle, David F Ackerley

Food Chem Toxicol· December 2023

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Molecular regulation of retinal regeneration is context specific.
Kevin Emmerich, John Hageter, Thanh Hoang, Pin Lyu, Abigail V Sharrock, David F Ackerley

bioRxiv· November 2023

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mRNA vaccine against malaria tailored for liver-resident memory T cells.
Mitch Ganley, Lauren E Holz, Jordan J Minnell, Maria N de Menezes, Olivia K Burn, David F Ackerley

Nat Immunol· September 2023

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An inducible model of chronic hyperglycemia.
Tori R Tucker, Courtney A Knitter, Deena M Khoury, Sheida Eshghi, Sophia Tran, David F Ackerley

Dis Model Mech· August 2023

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Directed Evolution of the BpsA Carrier Protein Domain for Recognition by Non-cognate 4'-Phosphopantetheinyl Transferases to Enable Inhibitor Screening.
Alistair S Brown, Jeremy G Owen, David F Ackerley

Methods Mol Biol· May 2023

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The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity.
Abigail V Sharrock, Jeff S Mumm, Gintautas Bagdžiūnas, Narimantas Čėnas, Vickery L Arcus, David F Ackerley

Int J Mol Sci· April 2023

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A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Michelle H Rich, Abigail V Sharrock, Timothy S Mulligan, Frazer Matthews, Alistair S Brown, David F Ackerley

bioRxiv· March 2023

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Development of a compartmentalised self-replication protocol for selection of superior blunt-end DNA ligases.
Luke J Stevenson, Katherine J Robins, Janine K Sharma, Elsie M Williams, Abigail V Sharrock, David F Ackerley

Enzyme Microb Technol· February 2023

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A New Transgenic Line for Rapid and Complete Neutrophil Ablation.
Christopher J Hall, Jonathan W Astin, Jeff S Mumm, David F Ackerley

Zebrafish· June 2022

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NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation.
Abigail V Sharrock, Timothy S Mulligan, Kelsi R Hall, Elsie M Williams, David T White, David F Ackerley

Nat Methods· February 2022

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Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications.
Amir Ashoorzadeh, Alexandra M Mowday, Christopher P Guise, Shevan Silva, Matthew R Bull, David F Ackerley

Pharmaceuticals (Basel)· February 2022

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Preparation of Soil Metagenome Libraries and Screening for Gene-Specific Amplicons.
Luke J Stevenson, David F Ackerley, Jeremy G Owen

Methods Mol Biol· January 2022

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Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3.
Maria R Abbattista, Amir Ashoorzadeh, Christopher P Guise, Alexandra M Mowday, Rituparna Mittra, David F Ackerley

Pharmaceuticals (Basel)· November 2021

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Skyllamycins D and E, Non-Ribosomal Cyclic Depsipeptides from Lichen-Sourced .
Joe Bracegirdle, Peng Hou, Vincent V Nowak, David F Ackerley, Robert A Keyzers

J Nat Prod· September 2021

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Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway.
Luke J Stevenson, Joe Bracegirdle, Liwei Liu, Abigail V Sharrock, David F Ackerley

RSC Chem Biol· April 2021

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