Publications by authors named "David B Berkowitz"

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Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol.
Gaurav P Kudalkar, Florian Leidner, Nivesh Kumar, Jared L Hass, Peter Madzelan, David B Berkowitz

Angew Chem Int Ed Engl· September 2025

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α-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via "Catalytically Correct" Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery?
Jonathan M Baine, Yoan Duhoo, Tzanko Doukov, Ambroise Desfosses, Giovanni Bisello, David B Berkowitz

ACS Catal· May 2025

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Identification of Potential Prophylactic Medical Countermeasures Against Acute Radiation Syndrome (ARS).
Kia T Liermann-Wooldrik, Arpita Chatterjee, Elizabeth A Kosmacek, Molly S Myers, Oluwaseun Adebisi, David B Berkowitz

Int J Mol Sci· April 2025

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Exploiting Archaeal/Thermostable Enzymes in Synthetic Chemistry: Back to the Future?
Gaurav P Kudalkar, Virendra K Tiwari, David B Berkowitz

ChemCatChem· November 2024

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Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Nathan Smith, Medhanjali Dasgupta, David C Wych, Cole Dolamore, Raymond G Sierra, David B Berkowitz

Sci Adv· March 2024

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Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography.
Nathan Smith, Medhanjali Dasgupta, David C Wych, Cole Dolamore, Raymond G Sierra, David B Berkowitz

bioRxiv· August 2023

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Information-Rich, Dual-Function C/H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme "Partitioning Fingerprint" and Reveals Disparate Chemotypes for hSR Inhibition.
Stephany M Ramos de Dios, Jared L Hass, Danielle L Graham, Nivesh Kumar, Aina E Antony, David B Berkowitz

J Am Chem Soc· February 2023

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A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures.
Sushil K Shakyawar, Nitish K Mishra, Neetha N Vellichirammal, Lynnette Cary, Tomáš Helikar, David B Berkowitz

Radiat Res· January 2023

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Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization.
Stephany M Ramos De Dios, Virendra K Tiwari, Christopher D McCune, Ranjeet A Dhokale, David B Berkowitz

Chem Rev· August 2022

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Rapid Enantioselective and Diastereoconvergent Hybrid Organic/Biocatalytic Entry into the Oseltamivir Core.
Virendra K Tiwari, Douglas R Powell, Sylvain Broussy, David B Berkowitz

J Org Chem· May 2021

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Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome.
Robert Moore, Bhanwar Lal Puniya, Robert Powers, Chittibabu Guda, Kenneth W Bayles, David B Berkowitz

Sci Rep· March 2021

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Author Correction: Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome.
Robert Moore, Bhanwar Lal Puniya, Robert Powers, Chittibabu Guda, Kenneth W Bayles, David B Berkowitz

Sci Rep· March 2021

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A Hammett Study of Clostridium acetobutylicum Alcohol Dehydrogenase (CaADH): An Enzyme with Remarkable Substrate Promiscuity and Utility for Organic Synthesis.
Gaurav P Kudalkar, Virendra K Tiwari, Joshua D Lee, David B Berkowitz

Synlett· February 2020

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Rapid Entry into Biologically Relevant α,α-Difluoroalkylphosphonates Bearing Allyl Protection-Deblocking under Ru(II)/(IV)-Catalysis.
Kaushik Panigrahi, Xiang Fei, Masato Kitamura, David B Berkowitz

Org Lett· December 2019

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Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis.
Medhanjali Dasgupta, Dominik Budday, Saulo H P de Oliveira, Peter Madzelan, Darya Marchany-Rivera, David B Berkowitz

Proc Natl Acad Sci U S A· December 2019

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Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.
Danielle L Graham, Matthew L Beio, David L Nelson, David B Berkowitz

Front Mol Biosci· March 2019

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Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Yupeng Tu, Cheryl A Kreinbring, Megan Hill, Cynthia Liu, Gregory A Petsko, David B Berkowitz

Biochemistry· June 2018

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The In Situ Enzymatic Screening (ISES) Approach to Reaction Discovery and Catalyst Identification.
Robert A Swyka, David B Berkowitz

Curr Protoc Chem Biol· December 2017

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Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.
Christopher D McCune, Matthew L Beio, Jill M Sturdivant, Roberto de la Salud-Bea, Brendan M Darnell, David B Berkowitz

J Am Chem Soc· October 2017

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Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.
David L Nelson, Greg A Applegate, Matthew L Beio, Danielle L Graham, David B Berkowitz

J Biol Chem· August 2017

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General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor.
Xiang Fei, Megan E Zavorka, Guillaume Malik, Christopher M Connelly, Richard G MacDonald, David B Berkowitz

Org Lett· August 2017

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"Zipped Synthesis" by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model.
Christopher D McCune, Su Jing Chan, Matthew L Beio, Weijun Shen, Woo Jin Chung, David B Berkowitz

ACS Cent Sci· April 2016

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Mini-ISES identifies promising carbafructopyranose-based salens for asymmetric catalysis: Tuning ligand shape via the anomeric effect.
Kannan R Karukurichi, Xiang Fei, Robert A Swyka, Sylvain Broussy, Weijun Shen, David B Berkowitz

Sci Adv· July 2015

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A useful methoxyvinyl cation equivalent: α-t-butyldimethylsilyl-α-methoxyacetaldehyde.
Christopher D McCune, Matthew L Beio, Jacob A Friest, Sandeep Ginotra, David B Berkowitz

Tetrahedron Lett· June 2015

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Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.
Gregory A Applegate, David B Berkowitz

Adv Synth Catal· May 2015

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