Publications by authors named "David B Neau"

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Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
Nathaniel C Gilbert, Jana Gerstmeier, Erin E Schexnaydre, Friedemann Börner, Ulrike Garscha, David B Neau, Oliver Werz, Marcia E Newcomer

July 2020

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Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium .
Ching Wooen Sze, Michael J Lynch, Kai Zhang, David B Neau, Steven E Ealick

mBio· April 2025

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Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium .
Ching Wooen Sze, Michael J Lynch, Kai Zhang, David B Neau, Steven E Ealick

bioRxiv· February 2025

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Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators.
Eden M Gallegos, Tanner D Reed, Forge A Mathes, Nelson V Guevara, David B Neau

J Biol Chem· September 2022

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Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Wan-Chen Tsai, Nathan C Gilbert, Amanda Ohler, Michelle Armstrong, Steven Perry, David B Neau

Bioorg Med Chem· September 2021

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Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
Logan D Andrews, Timothy R Kane, Paola Dozzo, Cat M Haglund, Darin J Hilderbrandt, David B Neau

J Med Chem· August 2019

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Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla.
Nathaniel C Gilbert, David B Neau, Marcia E Newcomer

Methods Enzymol· May 2019

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An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Svetlana Pakhomova, William E Boeglin, David B Neau, Sue G Bartlett, Alan R Brash

Protein Sci· May 2019

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C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Yang Wang, Tomasz Sosinowski, Andrey Novikov, Frances Crawford, David B Neau

Proc Natl Acad Sci U S A· January 2018

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Crystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide B.
Molly A Silvers, Svetlana Pakhomova, David B Neau, William C Silvers, Nicholas Anzalone

Biochemistry· August 2016

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Structural Basis of the Enhanced Pollutant-Degrading Capabilities of an Engineered Biphenyl Dioxygenase.
Sonali Dhindwal, Leticia Gomez-Gil, David B Neau, Thi Thanh My Pham, Michel Sylvestre

J Bacteriol· May 2016

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Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
Michael C Cavalier, Mohd Imran Ansari, Adam D Pierce, Paul T Wilder, Laura E McKnight, David B Neau

J Med Chem· January 2016

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Mechanistic Implications of the Unique Structural Features and Dimerization of the Cytoplasmic Domain of the Pseudomonas Sigma Regulator, PupR.
Jaime L Jensen, Andrea Balbo, David B Neau, Srinivas Chakravarthy, Huaying Zhao

Biochemistry· September 2015

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Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase.
Tyler C Broussard, Svetlana Pakhomova, David B Neau, Ross Bonnot, Grover L Waldrop

Biochemistry· June 2015

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Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex.
Jaime L Jensen, Venkata S K Indurthi, David B Neau, Stefan W Vetter, Christopher L Colbert

Acta Crystallogr D Biol Crystallogr· May 2015

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Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase.
David B Neau, Gunes Bender, William E Boeglin, Sue G Bartlett, Alan R Brash

J Biol Chem· November 2014

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Covalent small molecule inhibitors of Ca(2+)-bound S100B.
Michael C Cavalier, Adam D Pierce, Paul T Wilder, Milad J Alasady, Kira G Hartman, David B Neau

Biochemistry· October 2014

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The structure of human 15-lipoxygenase-2 with a substrate mimic.
Matthew J Kobe, David B Neau, Caitlin E Mitchell, Sue G Bartlett, Marcia E Newcomer

J Biol Chem· March 2014

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The three-dimensional structure of the biotin carboxylase-biotin carboxyl carrier protein complex of E. coli acetyl-CoA carboxylase.
Tyler C Broussard, Matthew J Kobe, Svetlana Pakhomova, David B Neau, Amanda E Price

Structure· April 2013

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Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Nathaniel C Gilbert, Zhe Rui, David B Neau, Maria T Waight, Sue G Bartlett

FASEB J· August 2012

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Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase.
Jarrod B French, David B Neau, Steven E Ealick

J Mol Biol· July 2011

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The structure of human 5-lipoxygenase.
Nathaniel C Gilbert, Sue G Bartlett, Maria T Waight, David B Neau, William E Boeglin

Science· January 2011

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The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
David B Neau, Nathaniel C Gilbert, Sue G Bartlett, William Boeglin, Alan R Brash

Biochemistry· August 2009

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Improving protein crystal quality by selective removal of a Ca(2+)-dependent membrane-insertion loop.
David B Neau, Nathaniel C Gilbert, Sue G Bartlett, Adam Dassey, Marcia E Newcomer

Acta Crystallogr Sect F Struct Biol Cryst Commun· November 2007

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Structural basis for ligand and heparin binding to neuropilin B domains.
Craig W Vander Kooi, Manuel A Jusino, Benjamin Perman, David B Neau, Henry D Bellamy

Proc Natl Acad Sci U S A· April 2007

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