July 2020 PMID 32393899

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.

Nathaniel C Gilbert, Jana Gerstmeier, Erin E Schexnaydre, Friedemann Börner, Ulrike Garscha, David B Neau, Oliver Werz, Marcia E Newcomer

Mentions

34
Peak: 3 in May 2020
across 5 sources since May 2020

Extended reach

4,055
potential audience

Total likes

34

Video views

2,777

Mentions per month

May 2020 – Nov 2020

Where it's discussed

  • News23 articles
  • Blogs4 articles
  • X / Twitter3 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions reflect a positive reception of the article’s insights, with phrases like 'showing anti-inflammatory mechanisms' and 'new potential for drug design' expressing appreciation for the research. Several posts confirm interest in how natural products inhibit enzymes, highlighting both the structural and therapeutic relevance, which underscores the overall moderate but meaningful impact of the study.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, especially highlighting how natural products like NDGA and AKBA can inhibit 5LOX in different ways, which could be valuable for developing new treatments.

InterestHigh interest

Participants demonstrate high interest, with enthusiasm evident in mentions of the potential applications and molecular mechanisms, showing curiosity about the implications of the research.

EngagementModerate engagement

Comments probe into the details of how these natural products work, indicating a moderate level of engaged analysis, though some posts mainly acknowledge the publication without deep discussion.

ImpactModerate impact

The recognition of potential for designing new inhibitors suggests that users see this as an important step toward innovative therapies for inflammatory diseases, even if it’s not viewed as immediately transformative.

Abstract in brief

  • The study compares how two natural products, NDGA and AKBA, inhibit the enzyme 5-lipoxygenase (5LOX), which is involved in producing leukotrienes that contribute to inflammation, asthma, and atherosclerosis.
  • NDGA binds directly to the active site of 5LOX, causing structural changes that fully expose the enzyme's catalytic region and strongly inhibit its activity, whereas AKBA binds allosterically (away from the active site), between two domains of the enzyme, leading to a shift in where the enzyme acts.
  • The findings highlight a new potential for designing specific 5LOX inhibitors by targeting allosteric sites like the one where AKBA binds, offering a different way to regulate enzyme activity and develop new treatments for inflammatory diseases.

Top posts

Most liked on X and Bluesky
ChemBioSys
@chembiosys_jena · X

New publication by the Werz group: Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. https://t.co/bOg1mOp2cd https://t.co/6RhFmClY8H

May 12, 2020 · 5 likes · 467 followers View post →
AJ Hagan
@AJHagan1 · X

Frankincense resin’s anti-inflammatory molecular mechanism shown.... Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products | Nature Chemical Biology https://t.co/wBTd6b3tgy

May 12, 2020 · 1 like · 94 followers View post →

All mentions

François Booream
@BooraemFrancois · X

https://t.co/NtYVK5VdmA

Nov 26, 2020 · 718 followers View post →
AJ Hagan
@AJHagan1 · X

Frankincense resin’s anti-inflammatory molecular mechanism shown.... Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products | Nature Chemical Biology https://t.co/wBTd6b3tgy

May 12, 2020 · 1 like · 94 followers View post →
ChemBioSys
@chembiosys_jena · X

New publication by the Werz group: Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. https://t.co/bOg1mOp2cd https://t.co/6RhFmClY8H

May 12, 2020 · 5 likes · 467 followers View post →