Publications by authors named "David B Sauer"

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Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.
Gangshun Yi, Dimitrios Mamalis, Mingda Ye, Loic Carrique, Michael Fairhead, David B Sauer

Nat Chem Biol· August 2025

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Metabolic mapping of the human solute carrier superfamily.
Tabea Wiedmer, Shao Thing Teoh, Eirini Christodoulaki, Gernot Wolf, Chengzhe Tian, David B Sauer

Mol Syst Biol· June 2025

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EAAT3 modulation: A potential novel avenue towards remyelination in multiple sclerosis.
Lieve van Veggel, Melissa Schepers, Assia Tiane, Vijay Kumar, Emily Willems, David B Sauer

Biomed Pharmacother· May 2025

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Structures of the human adult muscle-type nicotinic receptor in resting and desensitized states.
Anna Li, Ashley C W Pike, Richard Webster, Susan Maxwell, Wei-Wei Liu, David B Sauer

Cell Rep· May 2025

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Structural basis of the mechanism and inhibition of a human ceramide synthase.
Tomas C Pascoa, Ashley C W Pike, Christofer S Tautermann, Gamma Chi, Michael Traub, David B Sauer

Nat Struct Mol Biol· March 2025

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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2.
Huanyu Z Li, Ashley C W Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, David B Sauer

Nat Commun· January 2025

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Protein Binder Toolbox for Studies of Solute Carrier Transporters.
Zuzana Gelová, Alvaro Ingles-Prieto, Tina Bohstedt, Fabian Frommelt, Gamma Chi, David B Sauer

J Mol Biol· August 2024

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Pho pictures provide powerful perspectives of phosphate importing proteins.
David Speedman, David B Sauer

Structure· July 2024

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Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A M Mocking, Ulrich Goldmann, David B Sauer

Front Pharmacol· July 2024

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Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Huanyu Z Li, Ashley C W Pike, Irina Lotsaris, Gamma Chi, Jesper S Hansen, David B Sauer

Nat Commun· June 2024

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Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays.
Lieve van Veggel, Tamara A M Mocking, Hubert J Sijben, Rongfang Liu, Marina Gorostiola González, David B Sauer

ACS Chem Neurosci· April 2024

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The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Qiansheng Liang, Gamma Chi, Leonardo Cirqueira, Lianteng Zhi, Agostino Marasco, David B Sauer

Nat Commun· March 2024

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High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies.
Sagar Raturi, Huanyu Li, Yung-Ning Chang, Andreea Scacioc, Tina Bohstedt, David B Sauer

J Vis Exp· September 2023

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The solute carrier SPNS2 recruits PI(4,5)P to synergistically regulate transport of sphingosine-1-phosphate.
Haiping Tang, Huanyu Li, Dheeraj Prakaash, Conrado Pedebos, Xingyu Qiu, David B Sauer

Mol Cell· August 2023

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Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Douglas N Brawley, David B Sauer, Jianping Li, Xuhui Zheng, Akiko Koide

Nat Chem Biol· July 2022

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Structural basis of ion - substrate coupling in the Na-dependent dicarboxylate transporter VcINDY.
David B Sauer, Jennifer J Marden, Joseph C Sudar, Jinmei Song, Christopher Mulligan

Nat Commun· May 2022

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The ups and downs of elevator-type di-/tricarboxylate membrane transporters.
David B Sauer, Bing Wang, Joseph C Sudar, Jinmei Song, Jennifer Marden

FEBS J· March 2022

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Structure and inhibition mechanism of the human citrate transporter NaCT.
David B Sauer, Jinmei Song, Bing Wang, Jacob K Hilton, Nathan K Karpowich

Nature· March 2021

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Structural basis for the reaction cycle of DASS dicarboxylate transporters.
David B Sauer, Noah Trebesch, Jennifer J Marden, Nicolette Cocco, Jinmei Song

Elife· September 2020

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Predicting the optimal growth temperatures of prokaryotes using only genome derived features.
David B Sauer, Da-Neng Wang

Bioinformatics· September 2019

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Rapid Bioinformatic Identification of Thermostabilizing Mutations.
David B Sauer, Nathan K Karpowich, Jin Mei Song, Da-Neng Wang

Biophys J· October 2015

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The conserved potassium channel filter can have distinct ion binding profiles: structural analysis of rubidium, cesium, and barium binding in NaK2K.
Yee Ling Lam, Weizhong Zeng, David Bryant Sauer, Youxing Jiang

J Gen Physiol· August 2014

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Sodium and potassium competition in potassium-selective and non-selective channels.
David B Sauer, Weizhong Zeng, John Canty, Yeeling Lam, Youxing Jiang

Nat Commun· July 2014

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Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
Chunguang Kong, Weizhong Zeng, Sheng Ye, Liping Chen, David Bryant Sauer

Elife· December 2012

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Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger.
Jun Liao, Hua Li, Weizhong Zeng, David B Sauer, Ricardo Belmares

Science· February 2012

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