Publications by authors named "David Barford"

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Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome.
Rohan Eapen, Cynthia Okoye, Christopher Stubbs, Marianne Schimpl, Thomas Tischer, David Barford

Elife· September 2025

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Molecular mechanism of Mad2 conformational conversion promoted by the Mad2-interaction motif of Cdc20.
Conny W H Yu, Elyse S Fischer, Joe G Greener, Jing Yang, Ziguo Zhang, David Barford

Protein Sci· April 2025

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Cryo-EM structures of apo-APC/C and APC/C complexes provide insights into APC/C regulation.
Anna Höfler, Jun Yu, Jing Yang, Ziguo Zhang, Leifu Chang, David Barford

Nat Commun· November 2024

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A comparative study of the cryo-EM structures of and human anaphase-promoting complex/cyclosome (APC/C).
Ester Vazquez-Fernandez, Jing Yang, Ziguo Zhang, Antonina E Andreeva, Paul Emsley, David Barford

Elife· October 2024

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Structure of the native γ-tubulin ring complex capping spindle microtubules.
Tom Dendooven, Stanislau Yatskevich, Alister Burt, Zhuo A Chen, Dom Bellini, David Barford

Nat Struct Mol Biol· July 2024

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Structure of the human outer kinetochore KMN network complex.
Stanislau Yatskevich, Jing Yang, Dom Bellini, Ziguo Zhang, David Barford

Nat Struct Mol Biol· June 2024

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Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules.
Kyle W Muir, Christopher Batters, Tom Dendooven, Jing Yang, Ziguo Zhang, David Barford

Science· December 2023

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Conserved and divergent mechanisms of inner kinetochore assembly onto centromeric chromatin.
Stanislau Yatskevich, David Barford, Kyle W Muir

Curr Opin Struct Biol· August 2023

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Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
Tom Dendooven, Ziguo Zhang, Jing Yang, Stephen H McLaughlin, Johannes Schwab, David Barford

Sci Adv· July 2023

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Structural biology of DOCK-family guanine nucleotide exchange factors.
Andreas Boland, Jean-Francois Côté, David Barford

FEBS Lett· March 2023

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Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.
Viviane Tran, Sarah Nahlé, Amélie Robert, Inès Desanlis, Ryan Killoran, David Barford

Nat Commun· November 2022

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Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer.
Owen J Chen, Ester Castellsagué, Mohamed Moustafa-Kamal, Javad Nadaf, Barbara Rivera, David Barford

Cancer Res· October 2022

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Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly.
Elyse S Fischer, Conny W H Yu, Johannes F Hevler, Stephen H McLaughlin, Sarah L Maslen, David Barford

Nat Commun· October 2022

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Molecular architecture of the augmin complex.
Clinton A Gabel, Zhuang Li, Andrew G DeMarco, Ziguo Zhang, Jing Yang, David Barford

Nat Commun· September 2022

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Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Stanislau Yatskevich, Kyle W Muir, Dom Bellini, Ziguo Zhang, Jing Yang, David Barford

Science· May 2022

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The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly.
Thomas Tischer, Jing Yang, David Barford

J Cell Sci· January 2022

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Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Jun Yu, Pierre Raia, Chloe M Ghent, Tobias Raisch, Yashar Sadian, David Barford

Nature· August 2021

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Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1.
Elyse S Fischer, Conny W H Yu, Dom Bellini, Stephen H McLaughlin, Christian M Orr, David Barford

EMBO Rep· July 2021

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Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation.
Stanislau Yatskevich, Jessie S Kroonen, Claudio Alfieri, Thomas Tischer, Anna C Howes, David Barford

Cell Rep· March 2021

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Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP.
Katerina Naydenova, Kyle W Muir, Long-Fei Wu, Ziguo Zhang, Francesca Coscia, David Barford

Proc Natl Acad Sci U S A· February 2021

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Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex.
Ziguo Zhang, Dom Bellini, David Barford

Nucleic Acids Res· November 2020

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Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Leifu Chang, Jing Yang, Chang Hwa Jo, Andreas Boland, Ziguo Zhang, David Barford

Nat Commun· July 2020

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A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Claudio Alfieri, Thomas Tischer, David Barford

EMBO Rep· June 2020

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Structural interconversions of the anaphase-promoting complex/cyclosome (APC/C) regulate cell cycle transitions.
David Barford

Curr Opin Struct Biol· April 2020

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Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.
Kaige Yan, Jing Yang, Ziguo Zhang, Stephen H McLaughlin, Leifu Chang, David Barford

Nature· October 2019

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