Publications by authors named "David Barnes-Seeman"

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Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands.
Jeffrey T Bagdanoff, Thomas M Smith, Martin Allan, Peter O'Donnell, Zachary Nguyen, David Barnes-Seeman

Cell Chem Biol· January 2023

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Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
Edwige Lorthiois, James Roache, David Barnes-Seeman, Eva Altmann, Ulrich Hassiepen

J Med Chem· August 2020

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Correlation Between Nasal Epithelial Injury and In Vitro Cytotoxicity Using a Series of Small Molecule Protein Tyrosine Phosphatase 1B Inhibitors Investigated for Reversal of Leptin Resistance in Obesity.
Alan P Brown, Chandrassegar Saravanan, Patrick Devine, Maria Magnifico, Jiaping Gao, David Barnes-Seeman

Int J Toxicol· April 2018

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Fluorinated compounds in medicinal chemistry: recent applications, synthetic advances and matched-pair analyses.
David Barnes-Seeman, Jeremy Beck, Clayton Springer

Curr Top Med Chem· November 2014

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Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.
David Barnes-Seeman, Carri Boiselle, Christina Capacci-Daniel, Rajiv Chopra, Keith Hoffmaster

Bioorg Med Chem Lett· August 2014

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Metabolically Stable tert-Butyl Replacement.
David Barnes-Seeman, Monish Jain, Leslie Bell, Suzie Ferreira, Scott Cohen

ACS Med Chem Lett· June 2013

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A robust small-molecule microarray platform for screening cell lysates.
James E Bradner, Olivia M McPherson, Ralph Mazitschek, David Barnes-Seeman, John P Shen

Chem Biol· May 2006

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Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands.
David Barnes-Seeman, Seung Bum Park, Angela N Koehler, Stuart L Schreiber

Angew Chem Int Ed Engl· May 2003

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