Publications by authors named "David Bearss"

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Ofirnoflast: a first-in-class NEK7-targeted inhibitor of the NLRP3 inflammasome.
Alexis Mollard, Devan Bursey, William Burnett, Taylor Avei, Benjamin Bearss, Jared Bearss, David Bearss

J Drug Target· August 2025

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Two-component T-cell immunotherapy enables antigen pre-targeting to reduce cytokine release without forfeiting efficacy.
M Tommy Gambles, Isaac Kendell, Jiahui Li, Kyle Spainhower, Douglas Sborov, David Bearss

Nanomedicine· July 2025

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A prospective biomarker analysis of alvocidib followed by cytarabine and mitoxantrone in MCL-1-dependent relapsed/refractory acute myeloid leukemia.
Joshua F Zeidner, Tara L Lin, Carlos E Vigil, Gil Fine, M Yair Levy, David Bearss

Blood Cancer J· October 2021

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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
Tsz-Yin Chan, Christina M Egbert, Julia E Maxson, Adam Siddiqui, Logan J Larsen, David J Bearss

Nat Commun· September 2021

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Upregulation of AXL and β-catenin in chronic lymphocytic leukemia cells cultured with bone marrow stroma cells is associated with enhanced drug resistance.
Sutapa Sinha, Charla R Secreto, Justin C Boysen, Connie Lesnick, Zhiquan Wang, David J Bearss

Blood Cancer J· February 2021

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Phase I Study of Alvocidib Followed by 7+3 (Cytarabine + Daunorubicin) in Newly Diagnosed Acute Myeloid Leukemia.
Joshua F Zeidner, Daniel J Lee, Mark Frattini, Gil D Fine, Judy Costas, David Bearss

Clin Cancer Res· January 2021

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Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer.
Josephine A Taverna, Chia-Nung Hung, Daniel T DeArmond, Meizhen Chen, Chun-Lin Lin, David J Bearss

Cancer Res· April 2020

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Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors.
Simon L Currie, Steven L Warner, Hariprasad Vankayalapati, Xiaohui Liu, Sunil Sharma, David J Bearss

SLAS Discov· January 2019

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Chronic lymphocytic leukemia cells from ibrutinib treated patients are sensitive to Axl receptor tyrosine kinase inhibitor therapy.
Sutapa Sinha, Justin C Boysen, Kari G Chaffee, Brian F Kabat, Susan L Slager, David J Bearss

Oncotarget· December 2018

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Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors.
Ting Chen, Venkataswamy Sorna, Susie Choi, Lee Call, Jared Bearss, David J Bearss

Bioorg Med Chem Lett· December 2017

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Combined venetoclax and alvocidib in acute myeloid leukemia.
James Bogenberger, Clifford Whatcott, Nanna Hansen, Devora Delman, Chang-Xin Shi, David Bearss

Oncotarget· December 2017

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Patterns and Significance of PIM Kinases in Urothelial Carcinoma.
Daniel J Albertson, Robert L Schmidt, Jared J Bearss, Sheryl R Tripp, David J Bearss

Appl Immunohistochem Mol Morphol· August 2016

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Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis.
Laura Jimenez, Jindong Wang, Monique A Morrison, Clifford Whatcott, Katherine K Soh, David Bearss

Dis Model Mech· April 2016

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Are Accurins the cure for Aurora kinase inhibitors?
David J Bearss

Sci Transl Med· February 2016

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Inhibition of Nek2 by small molecules affects proteasome activity.
Lingyao Meng, Kent Carpenter, Alexis Mollard, Hariprasad Vankayalapati, Steven L Warner, David J Bearss

Biomed Res Int· July 2015

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Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors.
Sutapa Sinha, Justin Boysen, Michael Nelson, Charla Secreto, Steven L Warner, David J Bearss

Clin Cancer Res· May 2015

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Activators of PKM2 in cancer metabolism.
Steven L Warner, Kent J Carpenter, David J Bearss

Future Med Chem· June 2014

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A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas.
Jason M Foulks, Kent J Carpenter, Bai Luo, Yong Xu, Anna Senina, Jared J Bearss, David J Bearss

Neoplasia· May 2014

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High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.
Venkataswamy Sorna, Emily R Theisen, Bret Stephens, Steven L Warner, David J Bearss

J Med Chem· December 2013

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Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents.
Yong Xu, Benjamin Brenning, Adrianne Clifford, David Vollmer, Jared Bearss, David J Bearss

ACS Med Chem Lett· December 2013

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TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.
Xiaoping Wang, Hitomi Saso, Takayuki Iwamoto, Weiya Xia, Yun Gong, David J Bearss

Cancer Res· November 2013

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Use of a bacteriophage lysin to identify a novel target for antimicrobial development.
Raymond Schuch, Adam J Pelzek, Assaf Raz, Chad W Euler, Patricia A Ryan, David J Bearss

PLoS One· October 2013

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Discovery of biologically active oncologic and immunologic small molecule therapies using zebrafish: overview and example of modulation of T cell activation.
Nikolaus S Trede, William Heaton, Suzanne Ridges, Hossein Sofla, Matthew Cusick, David Bearss

Curr Protoc Pharmacol· March 2013

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Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.
Kaitlin J Basham, Collin Kieffer, Dawne N Shelton, Christopher J Leonard, Vasudev R Bhonde, David J Bearss

J Biol Chem· January 2013

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NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers.
Wen Zhou, Ye Yang, Jiliang Xia, He Wang, Mohamed E Salama, David Bearss

Cancer Cell· January 2013

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