Publications by authors named "David Brealey"

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Reliability of an all-in-one wearable sensor for continuous vital signs monitoring in high-risk patients: the NIGHTINGALE clinical validation study.
Martine J M Breteler, Ellen Leigard, Lisa C Hartung, John R Welch, David A Brealey

J Clin Monit Comput· October 2025

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Plasma from patients with sepsis induces release of neutrophil extracellular traps from healthy volunteer neutrophils ex vivo.
Antoine Villa, Haiyan Xue, Marie Scully, Sascha David, Georgia Bercades, David Brealey

Br J Anaesth· October 2025

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The amphiregulin- epidermal growth factor receptor axis as a therapeutic target in sepsis.
Rebecca Walsh, Timothy Arthur Chandos Snow, Alexandra Z Martinez, David Brealey, Mervyn Singer

Front Immunol· October 2025

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Peri-Operative Antimicrobial Prophylaxis Modulates CD4 Lymphocyte Immunophenotype in High-Risk Patients Undergoing Major Elective Surgery-A Preliminary Observational Study.
Susi Paketci, Jack Williams, Walter Pisciotta, Richard Loye, Alessia V Waller, David Brealey

Antibiotics (Basel)· October 2025

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Digital integration of research conduct into clinical care: results of the PROSPECTOR randomised feasibility study.
Matthew G Wilson, Folkert W Asselbergs, Nausheen Saleem, Lelia Jeilani, David Brealey

BMJ Evid Based Med· September 2025

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Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness.
Anna Kleyman, Walter Pisciotta, Charlotte Gaupp, Waqas Khaliq, Daniel Hofmaenner, David Brealey

Crit Care· September 2025

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Label-Free Electrochemical Interleukin-6 Sensor Exploiting rGO-TiCT MXene Nanocomposites.
Rohit Gupta, Ashish Kalkal, Priya Mandal, Diptiranjan Paital, David Brealey

ACS Appl Mater Interfaces· August 2025

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Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
Timothy S Walsh, Richard A Parker, Leanne M Aitken, Cathrine A McKenzie, Lydia Emerson, David Brealey

JAMA· July 2025

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Preoperative activation of the renin-angiotensin system and myocardial injury in noncardiac surgery: exploratory mechanistic analysis of the SPACE randomised controlled trial.
Ana Gutierrez Del Arroyo, Tom E F Abbott, Akshaykumar Patel, Salma Begum, Priyanthi Dias, David Brealey

Br J Anaesth· May 2025

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The Search for Sepsis Biomarkers: A Tale of Promises, Pitfalls, and Potential.
Tobias Zimmermann, David Brealey, Mervyn Singer

Crit Care Med· March 2025

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Guidelines vs mindlines: a qualitative investigation of how clinicians' beliefs influence the application of rapid molecular diagnostics in intensive care.
Sarah-Jane F Stewart, Alyssa M Pandolfo, Yogini Jani, Zoe Moon, David Brealey

Antimicrob Agents Chemother· March 2025

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An international observational study validating gene-expression sepsis immune subgroups.
David B Antcliffe, Estelle Peronnet, Frédéric Pène, Kristoffer Strålin, David Brealey

Crit Care· March 2025

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Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.
Paul Dark, Anower Hossain, Daniel F McAuley, David Brealey, Gordon Carlson

JAMA· February 2025

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INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia.
Virve I Enne, Susan Stirling, Julie A Barber, Juliet High, Charlotte Russell, David Brealey

Intensive Care Med· February 2025

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Immune biomarkers and secondary hemophagocytic lymphohistiocytosis: a scoping review protocol.
Alice Terrett, Magalie Van Loo, Krishnaswamy Sundararajan, David Brealey, Mervyn Singer

JBI Evid Synth· January 2025

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A randomised controlled trial of plasma exchange compared to standard of care in the treatment of severe COVID-19 infection (COVIPLEX).
Nishkantha Arulkumaran, Mari Thomas, Matthew Stubbs, Nithya Prasanna, Maryam Subhan, David Brealey

Sci Rep· July 2024

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Diagnosing sepsis: where we're at and where we're going.
Tobias Zimmermann, David Brealey, Mervyn Singer

Intensive Care Med· June 2024

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Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin-angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial.
Ana Gutierrez Del Arroyo, Akshaykumar Patel, Tom E F Abbott, Salma Begum, Priyanthi Dias, David Brealey

Br J Anaesth· May 2024

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Critical care utilisation for patients receiving chimeric antigen receptor (CAR) T cell therapy in the UK.
Tasneem Pirani, Anthony Wilson, David Brealey, Ryan Low, Suzanne O'Neill

Br J Anaesth· May 2024

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Discontinuation vs. continuation of renin-angiotensin system inhibition before non-cardiac surgery: the SPACE trial.
Gareth L Ackland, Akshaykumar Patel, Tom E F Abbott, Salma Begum, Priyanthi Dias, David Brealey

Eur Heart J· April 2024

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Early dynamic changes to monocytes following major surgery are associated with subsequent infections.
Timothy Arthur Chandos Snow, Alessia V Waller, Richard Loye, Francis Ryckaert, Antonio Cesar, David Brealey

Front Immunol· April 2024

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Adult Cerebral Malaria: Acute and Subacute Imaging Findings, Long-term Clinical Consequences.
Charles Coughlan, Hans Rolf Jäger, David Brealey, Francesco Carletti, Harpreet Hyare

Clin Infect Dis· February 2024

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UK clinicians' attitudes towards the application of molecular diagnostics to guide antibiotic use in ICU patients with pneumonias: a quantitative study.
Sarah-Jane F Stewart, Alyssa M Pandolfo, Zoe Moon, Yogini Jani, Stephen J Brett, David Brealey

J Antimicrob Chemother· January 2024

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Immunophenotyping patients with sepsis and underlying haematological malignancy reveals defects in monocyte and lymphocyte function.
Timothy Arthur Chandos Snow, Aimee Serisier, David Brealey, Mervyn Singer, Nishkantha Arulkumaran

Intensive Care Med Exp· January 2024

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A randomized controlled trial of nebulized surfactant for the treatment of severe COVID-19 in adults (COVSurf trial).
Ahilanandan Dushianthan, Howard W Clark, David Brealey, Danny Pratt, James B Fink

Sci Rep· November 2023

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