Publications by authors named "David Cousin"

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Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation.
Andrew Novak, David Laughton, Rebecca Lane, Emma Blackham, Jennifer Thomas, David Cousin

J Med Chem· December 2022

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Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Tom D Heightman, Valerio Berdini, Luke Bevan, Ildiko M Buck, Maria G Carr, David Cousin

J Med Chem· August 2021

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Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Tom D Heightman, Valerio Berdini, Hannah Braithwaite, Ildiko M Buck, Megan Cassidy, David Cousin

J Med Chem· June 2018

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Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.
David Cousin, Marc G Hummersone, Tracey D Bradshaw, Jihong Zhang, Christopher J Moody

Medchemcomm· March 2018

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A new approach to combretastatin D2.
David Cousin, John Mann, Mark Nieuwenhuyzen, Hendrik van den Berg

Org Biomol Chem· January 2006

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