Publications by authors named "David D Thomas"

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Large-scale high-throughput screen for cardiac ryanodine receptor targeted therapeutics.
Roman Nikolaienko, Elisa Bovo, Jonathan C Solberg, Marzena Brinkmann, Levy M Treinen, David D Thomas, Jennifer J Thomas

J Biol Chem· November 2025

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Development of activators for SERCA2a for heart failure treatments.
Marzena Brinkmann, Tsung-Yun Kent Wong, Osha Roopnarine, Samantha L Yuen, Kaja Berg, David D Thomas

Eur J Med Chem· November 2025

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A FRET assay to monitor different structural states of human β-cardiac myosin including the interacting-heads motif.
Rama Reddy Goluguri, Piyali Guhathakurta, Neha Nandwani, Aminah Dawood, Seiji Yokota, David D Thomas

Proc Natl Acad Sci U S A· August 2025

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Tyrosine-Mediated Static and Dynamic Quenching of a Receptor Tyrosine Kinase Biosensor Reveals Inhibitor Binding Modes and Kinase Conformations.
Zachary D Baker, Andrew R Thompson, David D Thomas, Nicholas M Levinson

ACS Chem Biol· July 2025

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Myosin relaxation states in skeletal muscle fibers of rats and mice: Effects of sex and adiposity.
Zachery A Roloff, Lien A Phung, Luke A Weyrauch, Philip C Woods, Shawna L McMillin, David D Thomas

Physiol Rep· April 2025

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Kinetics insight into the roles of the N- and C-lobes of calmodulin in RyR1 channel regulation.
Jingyan Zhang, Levy M Treinen, Skylar J Mast, Megan R McCarthy, Bengt Svensson, David D Thomas

J Biol Chem· March 2025

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Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif.
Nidhi Joshi, Katie M Dunleavy, Kaitlin M Beel, Tiffany A Engel, Andrew R Thompson, David D Thomas

Biochem J· March 2025

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A FRET assay to quantitate levels of the human β-cardiac myosin interacting heads motif based on its near-atomic resolution structure.
Rama Reddy Goluguri, Piyali Guhathakurta, Neha Nandwani, Aminah Dawood, Seiji Yakota, David D Thomas

bioRxiv· December 2024

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Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors.
Robyn T Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D Thomas

Nat Commun· June 2024

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Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
Damien M Rasmussen, Manny M Semonis, Joseph T Greene, Joseph M Muretta, Andrew R Thompson, David D Thomas

Elife· May 2024

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Structural Dynamics of Protein Interactions Using Site-Directed Spin Labeling of Cysteines to Measure Distances and Rotational Dynamics with EPR Spectroscopy.
Osha Roopnarine, David D Thomas

Appl Magn Reson· March 2024

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Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †.
Nagamani Vunnam, Malaney C Young, Elly E Liao, Chih Hung Lo, Evan Huber, David D Thomas

Cancer Biol Ther· December 2023

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Drug discovery for heart failure targeting myosin-binding protein C.
Thomas A Bunch, Piyali Guhathakurta, Andrew R Thompson, Victoria C Lepak, Anna L Carter, Jennifer J Thomas, David D Thomas

J Biol Chem· December 2023

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Regulation of cardiac calcium signaling by newly identified calcium pump modulators.
Elisa Bovo, Robyn T Rebbeck, Osha Roopnarine, Razvan L Cornea, David D Thomas

Biochem Biophys Res Commun· December 2023

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Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
Damien M Rasmussen, Manny M Semonis, Joseph T Greene, Joseph M Muretta, Andrew R Thompson, David D Thomas

bioRxiv· November 2023

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RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET.
Jaroslava Šeflová, Jacob A Schwarz, Abigail N Smith, Bengt Svensson, Daniel J Blackwell, David D Thomas

ACS Chem Biol· October 2023

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Cardiomyopathy-associated variants alter the structure and function of the α-actinin-2 actin-binding domain.
Alexandra E Atang, Robyn T Rebbeck, David D Thomas, Adam W Avery

Biochem Biophys Res Commun· August 2023

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Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State.
Bengt Svensson, Florentin R Nitu, Robyn T Rebbeck, Lindsey M McGurran, Tetsuro Oda, David D Thomas

Int J Mol Sci· August 2023

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Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators.
Osha Roopnarine, Samantha L Yuen, Andrew R Thompson, Lauren N Roelike, Robyn T Rebbeck, David D Thomas

Sci Rep· July 2023

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Advancements in a FRET Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein.
Anthony R Braun, Noah Nathan Kochen, Samantha L Yuen, Elly E Liao, Razvan L Cornea, David D Thomas

ASN Neuro· July 2023

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Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State.
Bengt Svensson, Florentin R Nitu, Robyn T Rebbeck, Lindsey M McGurran, Tetsuro Oda, David D Thomas

bioRxiv· July 2023

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Drug discovery for heart failure targeting myosin-binding protein C.
Thomas A Bunch, Piyali Guhathakurta, Andrew R Thompson, Victoria C Lepak, Anna L Carter, Jennifer J Thomas, David D Thomas

bioRxiv· April 2023

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FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators.
Osha Roopnarine, Samantha L Yuen, Andrew R Thompson, Lauren N Roelike, Robyn T Rebbeck, David D Thomas

bioRxiv· February 2023

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FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators.
Osha Roopnarine, Samantha L Yuen, Andrew R Thompson, Lauren N Roelike, Robyn T Rebbeck, David D Thomas

Res Sq· February 2023

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Indirubin Inhibits TRAIL-Induced Activation of Death Receptor 5 in Jurkat Cells.
Malaney C Young, Nagamani Vunnam, Robyn T Rebbeck, Samantha L Yuen, David D Thomas

Nat Prod Commun· January 2023

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