Publications by authors named "David Denardo"

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Targeting tumor-intrinsic TAK1 triggers anti-tumor immunity and sensitizes pancreatic cancer to checkpoint blockade.
Sapana P Bansod, Timothy Hung-Po Chen, Vikas K Somani, Lin Li, Suneeta Modekurty, David G DeNardo

bioRxiv· October 2025

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Neoadjuvant BMS-813160, Nivolumab, Gemcitabine, and Nab-Paclitaxel for Patients with Pancreatic Cancer.
Patrick M Grierson, Crystal Wolf, Rama Suresh, Andrea Wang-Gillam, Benjamin R Tan, David G DeNardo

Clin Cancer Res· September 2025

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Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories.
Jeanette A I Johnson, Daniel R Bergman, Heber L Rocha, David L Zhou, Eric Cramer, David G DeNardo

Cell· August 2025

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Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer.
Graham D Hogg, Alyssa G Weinstein, Natalie L Kingston, Xiuting Liu, Olivia M Dres, David G DeNardo

Sci Immunol· August 2025

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M3NetFlow: A multi-scale multi-hop graph AI model for integrative multi-omic data analysis.
Heming Zhang, S Peter Goedegebuure, Li Ding, David DeNardo, Ryan C Fields

iScience· March 2025

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HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma.
Naomi Yamamoto, Stephanie Dobersch, Ian Loveless, Annie N Samraj, Gun Ho Jang, David G DeNardo

Clin Cancer Res· February 2025

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Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas.
Jing Chen, Michal Sobecki, Ewelina Krzywinska, Kevin Thierry, Mélissa Masmoudi, David DeNardo

EMBO Mol Med· December 2024

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Targeting dendritic cells to drive PDAC immunotherapy response.
Alyssa G Weinstein, David G DeNardo

Trends Pharmacol Sci· December 2024

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Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity.
Kay Hänggi, Jie Li, Achintyan Gangadharan, Xiaoxian Liu, Daiana P Celias, David G DeNardo

Cancer Cell· December 2024

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Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy.
Xiuting Liu, John M Baer, Meredith L Stone, Brett L Knolhoff, Graham D Hogg, David G DeNardo

Sci Transl Med· October 2024

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M3NetFlow: A novel multi-scale multi-hop graph AI model for integrative multi-omic data analysis.
Heming Zhang, S Peter Goedegebuure, Li Ding, David DeNardo, Ryan C Fields

bioRxiv· September 2024

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Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia.
Siling Du, Antoine Drieu, Yumeng Cheng, Steffen E Storck, Justin Rustenhoven, David DeNardo

bioRxiv· August 2024

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Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer.
Jad I Belle, Devashish Sen, John M Baer, Xiuting Liu, Varintra E Lander, David G DeNardo

Cancer Discov· July 2024

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Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression.
Jiayu Ye, John M Baer, Douglas V Faget, Vasilios A Morikis, Qihao Ren, David G DeNardo

Cancer Discov· July 2024

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Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma.
Vikram S Pothuri, Graham D Hogg, Leah Conant, Nicholas Borcherding, C Alston James, David G DeNardo

Oncoimmunology· March 2024

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Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer.
Ashenafi Bulle, Peng Liu, Kuljeet Seehra, Sapana Bansod, Yali Chen, David G DeNardo

Nat Commun· March 2024

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Pancreatic Cancer's PD1-Roadblock: When T-Cell Reinvigoration Is Not Enough.
Varintra E Lander, David G DeNardo

Clin Cancer Res· February 2024

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"RIPping" off Pancreas Cancer's Blockage of Immune Surveillance.
Xiuting Liu, Blake E Sells, David G DeNardo

Cancer Discov· February 2024

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sc2MeNetDrug: A computational tool to uncover inter-cell signaling targets and identify relevant drugs based on single cell RNA-seq data.
Jiarui Feng, S Peter Goedegebuure, Amanda Zeng, Ye Bi, Ting Wang, David DeNardo

PLoS Comput Biol· January 2024

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Chemokine Receptor 2 Targeted PET/CT Imaging Distant Metastases in Pancreatic Ductal Adenocarcinoma.
Xiaohui Zhang, Lisa Detering, Gyu Seong Heo, Deborah Sultan, Hannah Luehmann, David G DeNardo

ACS Pharmacol Transl Sci· January 2024

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Epigenetic regulation during cancer transitions across 11 tumour types.
Nadezhda V Terekhanova, Alla Karpova, Wen-Wei Liang, Alexander Strzalkowski, Siqi Chen, David G DeNardo

Nature· November 2023

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Correction: Defactinib, Pembrolizumab, and Gemcitabine in Patients with Advanced Treatment Refractory Pancreatic Cancer: a Phase I Dose Escalation and Expansion Study.
Andrea Wang-Gillam, Kian-Huat Lim, Robert McWilliams, Rama Suresh, Albert C Lockhart, David G DeNardo

Clin Cancer Res· November 2023

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High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival.
Erik P Storrs, Prathamesh Chati, Abul Usmani, Ian Sloan, Bradley A Krasnick, David G Denardo

NPJ Precis Oncol· October 2023

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Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC.
John M Baer, Chong Zuo, Liang-I Kang, Angela Alarcon de la Lastra, Nicholas C Borcherding, David G DeNardo

Nat Immunol· September 2023

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A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma.
Subhajit Ghosh, Tanner M Johanns, Milan G Chheda, Eric Liu, Omar Butt, David DeNardo

Neurooncol Adv· July 2023

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