Publications by authors named "David E Durrant"

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An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state.
Daniel A Ritt, David E Durrant, Matthew R Drew, Suzanne I Sandin, Juliana A Martinez Fiesco

Proc Natl Acad Sci U S A· September 2025

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Free energy and flexibility analysis of autoinhibited human BRAF.
Jeremy O B Tempkin, Fikret Aydin, Sebnem Essiz, Yue Yang, Timothy S Carpenter, David E Durrant

bioRxiv· August 2025

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An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State.
Daniel A Ritt, David E Durrant, Matthew R Drew, Suzanne I Sandin, Juliana A Martinez Fiesco

bioRxiv· August 2025

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Tolypocladamides A-G: Cytotoxic Peptaibols from .
Sarath P D Senadeera, Dongdong Wang, Chang-Kwon Kim, Emily A Smith, David E Durrant

J Nat Prod· June 2022

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Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
Juliana A Martinez Fiesco, David E Durrant, Deborah K Morrison, Ping Zhang

Nat Commun· January 2022

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Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction.
David E Durrant, Emily A Smith, Ekaterina I Goncharova, Nirmala Sharma, Patrick A Alexander

Mol Cancer Ther· September 2021

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A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines.
David E Durrant, Anindita Das, Samya Dyer, Rakesh C Kukreja

Biochim Biophys Acta Gen Subj· June 2020

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Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge That Inhibit Ras/Raf Interaction.
Chang-Kwon Kim, Dongdong Wang, Heidi R Bokesch, Richard W Fuller, Emily Smith, David E Durrant

J Nat Prod· April 2020

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling.
Elizabeth M Terrell, David E Durrant, Daniel A Ritt, Nancy E Sealover, Erin Sheffels

Mol Cell· December 2019

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Targeting the Raf kinases in human cancer: the Raf dimer dilemma.
David E Durrant, Deborah K Morrison

Br J Cancer· January 2018

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Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.
Daniel A Ritt, María T Abreu-Blanco, Lakshman Bindu, David E Durrant, Ming Zhou

Mol Cell· December 2016

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Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity.
David E Durrant, Anindita Das, Samya Dyer, Seyedmehrad Tavallai, Paul Dent

Mol Pharmacol· September 2015

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Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling.
Anindita Das, Fadi N Salloum, Scott M Filippone, David E Durrant, Gregg Rokosh

Basic Res Cardiol· May 2015

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Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.
Laurence Booth, Jane L Roberts, Nichola Cruickshanks, Adam Conley, David E Durrant

Mol Pharmacol· March 2014

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Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice.
Amit Varma, Anindita Das, Nicholas N Hoke, David E Durrant, Fadi N Salloum

PLoS One· February 2013

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Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor.
Lih-Ching Hsu, David E Durrant, Ching-Chun Huang, Nai-Wen Chi, Riccardo Baruchello

Invest New Drugs· August 2012

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Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins.
Daniele Simoni, Ray M Lee, David E Durrant, Nai-Wen Chi, Riccardo Baruchello

Bioorg Med Chem Lett· June 2010

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Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'-aminostilbene for optimization and use in cancer therapy.
David E Durrant, Joanna Richards, Ashutosh Tripathi, Glen E Kellogg, Paolo Marchetti

Invest New Drugs· February 2009

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