Publications by authors named "David Edmonds"

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"They are not taking it seriously": Constructing family dynamics in end-of-life care interactions in Hong Kong.
David Matthew Edmonds, Olga Zayts-Spence, Irene Nga Yu Au, Jacqueline Kwan Yuk Yuen

Death Stud· September 2025

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Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants.
Michelle R Garnsey, Yang Wang, David J Edmonds, Matthew F Sammons, Benjamin Reidich

Nat Commun· January 2025

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"I'm not an anxious person": end-of-life care workers constructing positive psychological states.
David Matthew Edmonds, Olga Zayts-Spence

BMC Psychol· August 2024

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A scoping review to map the research on the mental health of students and graduates during their university-to-work transitions.
David Matthew Edmonds, Olga Zayts-Spence, Zoë Fortune, Angus Chan, Jason Shang Guan Chou

BMJ Open· March 2024

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6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Gary E Aspnes, Scott W Bagley, Steven B Coffey, Edward L Conn, John M Curto, David J Edmonds

Bioorg Med Chem Lett· October 2023

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Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.
Kevin J Filipski, David J Edmonds, Michelle R Garnsey, Daniel J Smaltz, Karen Coffman

ACS Med Chem Lett· October 2023

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Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Shenping Liu, Ruth F Sommese, Nicole L Nedoma, Lucy Mae Stevens, Jason K Dutra, David J Edmonds

Nat Commun· August 2023

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Mental Health, Discourse and Stigma.
Olga Zayts-Spence, David Edmonds, Zoe Fortune

BMC Psychol· June 2023

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Mental health of new and recent graduates during the university-to-work transition: a scoping review protocol.
Olga Zayts, David Matthew Edmonds, Brandon Chee Kin Kong, Zoë Fortune

BMJ Open· April 2023

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A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
David A Griffith, David J Edmonds, Jean-Philippe Fortin, Amit S Kalgutkar, J Brent Kuzmiski

J Med Chem· June 2022

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A phase 1 trial of 4-(N-(S-penicillaminylacetyl)amino)-phenylarsonous acid (PENAO) in patients with advanced solid tumours.
Sunit Sarkar, Ben Tran, Lisa Horvath, Michael Lam, Peter Savas, David Edmonds

Cancer Chemother Pharmacol· May 2021

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Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
Kim Huard, Aaron C Smith, Gregg Cappon, Robert L Dow, David J Edmonds

J Med Chem· October 2020

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Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs.
David A Tess, Heather Eng, Amit S Kalgutkar, John Litchfield, David J Edmonds

J Med Chem· October 2020

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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Tim F Ryder, Matthew F Calabrese, Gregory S Walker, Kimberly O Cameron, Allan R Reyes, David J Edmonds

J Med Chem· August 2018

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
David J Edmonds, Daniel W Kung, Amit S Kalgutkar, Kevin J Filipski, David C Ebner

J Med Chem· March 2018

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Selective Activation of AMPK 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
Christopher T Salatto, Russell A Miller, Kimberly O Cameron, Emily Cokorinos, Allan Reyes, David J Edmonds

J Pharmacol Exp Ther· May 2017

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Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.
Fabien Plisson, Timothy A Hill, Justin M Mitchell, Huy N Hoang, Aline D de Araujo, David J Edmonds

Eur J Med Chem· February 2017

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Biomechanical, neuromuscular and knee pain effects following therapeutic knee taping among patients with knee osteoarthritis during walking gait.
David W Edmonds, Jenny McConnell, Jay R Ebert, Tim R Ackland, Cyril J Donnelly

Clin Biomech (Bristol)· November 2016

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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, Ravi G Kurumbail, Russell Miller, David J Edmonds

J Med Chem· September 2016

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Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
Joakim E Swedberg, Christina I Schroeder, Justin M Mitchell, David P Fairlie, David J Edmonds

J Biol Chem· July 2016

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Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.
Joakim E Swedberg, Christina I Schroeder, Justin M Mitchell, Thomas Durek, David P Fairlie, David J Edmonds

Eur J Med Chem· October 2015

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Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.
Huy N Hoang, Kun Song, Timothy A Hill, David R Derksen, David J Edmonds

J Med Chem· May 2015

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Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families.
Zhanchao Meng, Haixin Yu, Li Li, Wanyin Tao, Hao Chen, David J Edmonds

Nat Commun· February 2015

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Improving on nature: making a cyclic heptapeptide orally bioavailable.
Daniel S Nielsen, Huy N Hoang, Rink-Jan Lohman, Timothy A Hill, Andrew J Lucke, David J Edmonds

Angew Chem Int Ed Engl· November 2014

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Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed.
Timothy A Hill, Rink-Jan Lohman, Huy N Hoang, Daniel S Nielsen, Conor C G Scully, David J Edmonds

ACS Med Chem Lett· October 2014

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