Publications by authors named "David Gamm"

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AAV2.7m8 transduction of stage 2 human retinal organoids induces highly variable responses in innate and inflammatory gene expression and cytokine secretion.
Monica M Sauter, Hongyu Rao Noel, Divya Sinha, Emma C Nelson, Mai N Xiong, David M Gamm

Exp Eye Res· September 2025

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Preventing vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA.
Enes Akyuz, Pawan K Shahi, Lionel Gissot, Ahmad Al Saneh, Divya Sinha, David M Gamm

bioRxiv· July 2025

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Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation.
Raghavi Sudharsan, Natalia Dolgova, Jennifer Kwok, Alexa Gray, Yu Sato, David M Gamm

Stem Cell Res Ther· July 2025

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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Spencer C Wei, Aaron J Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, David M Gamm

PLoS One· June 2025

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Robust generation of photoreceptor-dominant retinal organoids from porcine induced pluripotent stem cells.
Kimberly L Edwards, Bethany M Moore, Tyler-Serie Ganser, Praveen Joseph Susaimanickam, Kai Sovell, David M Gamm

Stem Cell Reports· April 2025

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Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling Nonviral Genome Editing Efficiency.
Shivani Saxena, Meha Kabra, Amr Abdeen, Divya Sinha, Min Zhu, David M Gamm

bioRxiv· March 2025

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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Spencer C Wei, Aaron J Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, David M Gamm

bioRxiv· December 2024

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Transcriptomic Analysis of Metastatic Uveal Melanoma and Differences in Male and Female Patients.
Sishir Doddi, Abdul-Rizaq Hamoud, Hunter M Eby, Xiaolu Zhang, Ali Sajid Imami, David Gamm

Cancer Genomics Proteomics· June 2024

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Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.
Brittany N Williams, Adam Draper, Patrick F Lang, Tylor R Lewis, Audrey L Smith, David M Gamm

Hum Mol Genet· February 2024

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Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct.
In-Kyu Lee, Ruosen Xie, Agustin Luz-Madrigal, Seunghwan Min, Jingcheng Zhu, David M Gamm

Bioact Mater· December 2023

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Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy.
Meha Kabra, Pawan K Shahi, Yuyuan Wang, Divya Sinha, Allison Spillane, David M Gamm

J Clin Invest· October 2023

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A versatile laser-induced porcine model of outer retinal and choroidal degeneration for preclinical testing.
Francesca Barone, Juan Amaral, Irina Bunea, Mitra Farnoodian, Rohan Gupta, David M Gamm

JCI Insight· June 2023

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Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures.
Allison L Ludwig, Steven J Mayerl, Yu Gao, Mark Banghart, Cole Bacig, David M Gamm

Proc Natl Acad Sci U S A· January 2023

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Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment phenotype that models advanced retinitis pigmentosa.
Steven J Mayerl, Simona Bajgai, Allison L Ludwig, Lindsey D Jager, Brittany N Williams, David M Gamm

Stem Cell Reports· November 2022

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Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs.
Ana Ripolles-Garcia, Natalia Dolgova, M Joseph Phillips, Svetlana Savina, Allison L Ludwig, David M Gamm

Stem Cell Reports· August 2022

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autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids.
Kayvan Samimi, Bikash R Pattnaik, Elizabeth E Capowski, Krishanu Saha, David M Gamm

Biomed Opt Express· June 2022

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Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution.
Sarah K Rempel, Madalynn J Welch, Allison L Ludwig, M Joseph Phillips, Yochana Kancherla, David M Gamm

Cell Rep· May 2022

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Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.
Aindrila Saha, Elizabeth Capowski, Maria A Fernandez Zepeda, Emma C Nelson, David M Gamm

Cell Stem Cell· March 2022

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Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.
Aindrila Saha, Elizabeth Capowski, Maria A Fernandez Zepeda, Emma C Nelson, David M Gamm

Cell Stem Cell· March 2022

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CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids.
Karl J Wahlin, Jie Cheng, Shawna L Jurlina, Melissa K Jones, Nicholas R Dash, David M Gamm

Front Cell Dev Biol· November 2021

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Outer Retinal Cell Replacement: Putting the Pieces Together.
Allison L Ludwig, David M Gamm

Transl Vis Sci Technol· August 2021

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The NIH Somatic Cell Genome Editing program.
Krishanu Saha, Erik J Sontheimer, P J Brooks, Melinda R Dwinell, Charles A Gersbach, David M Gamm

Nature· April 2021

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Ultrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction.
In-Kyu Lee, Allison L Ludwig, M Joseph Phillips, Juhwan Lee, Ruosen Xie, David M Gamm

Sci Adv· April 2021

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Necrotizing myositis in a rectus muscle arising in the setting of long-standing Langerhans cell histiocystosis and recent dabrafenib treatment.
Suzanne W van Landingham, Diane Puccetti, Heather Potter, David Gamm, Eli L Diamond

Am J Ophthalmol Case Rep· December 2020

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Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy.
Divya Sinha, Benjamin Steyer, Pawan K Shahi, Katherine P Mueller, Rasa Valiauga, David M Gamm

Am J Hum Genet· August 2020

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