Publications by authors named "David Hangauer"

Claim this Profile
A
A phase Ib dose escalation study of oral monotherapy with KX2-391 in elderly patients with acute myeloid leukemia.
Margaret T Kasner, Molly B Halloran, Jonathan Pan, Ellen K Ritchie, Gerald J Fetterly, David G Hangauer

Invest New Drugs· August 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
Michael J Ciesielski, Yahao Bu, Stephan A Munich, Paola Teegarden, Michael P Smolinski, David G Hangauer

J Neurooncol· December 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).
Michael P Smolinski, Yahao Bu, James Clements, Irwin H Gelman, Taher Hegab, David G Hangauer

J Med Chem· June 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression.
Muralidharan Anbalagan, Mei Sheng, Brian Fleischer, Yifang Zhang, Yuanjun Gao, David Hangauer

Mol Cancer Res· November 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis.
Seongyeong Kim, Ahrum Min, Kyung-Hun Lee, Yaewon Yang, Tae-Yong Kim, David Hangauer

Cancer Res Treat· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation.
Nader N Nasief, Ahmed M Said, David Hangauer

Eur J Med Chem· January 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Ion Current-Based Proteomic Profiling for Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation.
Chengjian Tu, Yahao Bu, Marija Vujcic, Shichen Shen, Jun Li, David Hangauer

J Proteome Res· September 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Ligand binding cooperativity: Bioisosteric replacement of CO with SO2 among thrombin inhibitors.
Ahmed M Said, David G Hangauer

Bioorg Med Chem Lett· August 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors.
Ahmed M Said, David G Hangauer

Eur J Med Chem· February 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Additivity or cooperativity: which model can predict the influence of simultaneous incorporation of two or more functionalities in a ligand molecule?
Nader N Nasief, David Hangauer

Eur J Med Chem· January 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Influence of neighboring groups on the thermodynamics of hydrophobic binding: an added complex facet to the hydrophobic effect.
Nader N Nasief, David Hangauer

J Med Chem· March 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeting SRC and tubulin in mucinous ovarian carcinoma.
Tao Liu, Wei Hu, Heather J Dalton, Hyun Jin Choi, Jie Huang, David G Hangauer

Clin Cancer Res· December 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies.
Aung Naing, Roger Cohen, Grace K Dy, David S Hong, Lyn Dyster, David G Hangauer

Invest New Drugs· August 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer.
Emmanuel S Antonarakis, Elisabeth I Heath, Edwin M Posadas, Evan Y Yu, Michael R Harrison, David G Hangauer

Cancer Chemother Pharmacol· April 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dissecting the hydrophobic effect on the molecular level: the role of water, enthalpy, and entropy in ligand binding to thermolysin.
Adam Biela, Nader N Nasief, Michael Betz, Andreas Heine, David Hangauer

Angew Chem Int Ed Engl· February 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization of the cellular responses to novel anti-cancer agents in a prostate cell model.
Chengjian Tu, Jun Li, Yahao Bu, David Hangauer, Jun Qu

J Proteomics· December 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
W
Water mediated ligand functional group cooperativity: the contribution of a methyl group to binding affinity is enhanced by a COO(-) group through changes in the structure and thermodynamics of the hydration waters of ligand-thermolysin complexes.
Nader N Nasief, Hongwei Tan, Jing Kong, David Hangauer

J Med Chem· October 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts.
Muralidharan Anbalagan, Alaa Ali, Ryan K Jones, Carolyn G Marsden, Mei Sheng, David Hangauer

Mol Cancer Ther· September 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer.
Muralidharan Anbalagan, Latonya Carrier, Seth Glodowski, David Hangauer, Bin Shan

Breast Cancer Res Treat· April 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors.
Eric C Bielefeld, David Hangauer, Donald Henderson

Neurosci Res· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities.
Asal Fallah-Tafti, Alireza Foroumadi, Rakesh Tiwari, Amir Nasrolahi Shirazi, David G Hangauer

Eur J Med Chem· October 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Congeneric but still distinct: how closely related trypsin ligands exhibit different thermodynamic and structural properties.
Tobias Brandt, Nicole Holzmann, Laveena Muley, Maan Khayat, Christof Wegscheid-Gerlach, David Hangauer

J Mol Biol· February 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Non-additivity of functional group contributions in protein-ligand binding: a comprehensive study by crystallography and isothermal titration calorimetry.
Bernhard Baum, Laveena Muley, Michael Smolinski, Andreas Heine, David Hangauer

J Mol Biol· April 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors.
Laveena Muley, Bernhard Baum, Michael Smolinski, Marek Freindorf, Andreas Heine, David G Hangauer

J Med Chem· March 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
Bernhard Baum, Laveena Muley, Andreas Heine, Michael Smolinski, David Hangauer

J Mol Biol· August 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis