Publications by authors named "David J Robbins"

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The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling.
Sara Kassel, Kai Yuan, Nawat Bunnag, Leif R Neitzel, Wenhui Lu, David J Robbins

Nat Commun· June 2025

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RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription.
Nitish Jangde, Mi Hye Lee, Luz Ruiz, Isabelle Egan, Anna M Jermakowicz, David J Robbins

bioRxiv· May 2025

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Wnt signalosomes: What we know that we do not know.
Heather Hartmann, Ghalia Saad Siddiqui, Jamal Bryant, David J Robbins, Vivian L Weiss

Bioessays· February 2025

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Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A.
Chen Shen, Wenhui Lu, Siva B Merugu, Aradhana Bharti, Said M Afify, David J Robbins

Cell Rep· February 2025

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Exploring the role of casein kinase 1α splice variants across cancer cell lines.
Ricardo A Meléndez, Daniel T Wynn, Siva Bharath Merugu, Prerna Singh, Kenton P Kaplan, David J Robbins

Biochem Biophys Res Commun· September 2024

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Triptolide and its prodrug Minnelide target high-risk MYC-amplified medulloblastoma in preclinical models.
Jezabel Rodriguez-Blanco, April D Salvador, Robert K Suter, Marzena Swiderska-Syn, Isabel Palomo-Caturla, David J Robbins

J Clin Invest· June 2024

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The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.
Zachary T Spencer, Victoria H Ng, Hassina Benchabane, Ghalia Saad Siddiqui, Deepesh Duwadi, David J Robbins

Nat Commun· October 2023

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The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Victoria H Ng, Zachary Spencer, Leif R Neitzel, Anmada Nayak, Matthew A Loberg, David J Robbins

Nat Commun· October 2023

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USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.
Sara Kassel, Alison J Hanson, Hassina Benchabane, Kenyi Saito-Diaz, Carly R Cabel, David J Robbins

Sci Signal· February 2023

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A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth.
Fan Yang, Jezabel Rodriguez-Blanco, Jun Long, Marzena Swiderska-Syn, Daniel T Wynn, David J Robbins

Mol Cancer Res· November 2022

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Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer.
Fan Yang, Daniel T Wynn, Chen Shen, Nagi G Ayad, David J Robbins

Life (Basel)· November 2022

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Protein arginine methyltransferase 5 regulates SHH-subgroup medulloblastoma progression.
Daniel T Wynn, Jezabel Rodriguez-Blanco, Jun Long, Fan Yang, Chen Shen, David J Robbins

Neurooncol Adv· September 2022

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The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon.
Chen Shen, Anmada Nayak, Leif R Neitzel, Fan Yang, Bin Li, David J Robbins

J Biol Chem· August 2022

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The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
Chen Shen, Anmada Nayak, Leif R Neitzel, Amber A Adams, Maya Silver-Isenstadt, David J Robbins

Nat Commun· September 2021

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NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis.
Elena Shersher, Mohini Lahiry, Annamil Alvarez-Trotta, Giulia Diluvio, David J Robbins

Cell Commun Signal· September 2021

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Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells.
Annamil Alvarez-Trotta, William Guerrant, Luisana Astudillo, Mohini Lahiry, Giulia Diluvio, David J Robbins

Cancer Res· June 2021

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Opioids Impair Intestinal Epithelial Repair in HIV-Infected Humanized Mice.
Jingjing Meng, Santanu Banerjee, Li Zhang, Greg Sindberg, Shamsudheen Moidunny, David J Robbins

Front Immunol· December 2020

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Nuclear Regulation of Wnt/β-Catenin Signaling: It's a Complex Situation.
Christin C Anthony, David J Robbins, Yashi Ahmed, Ethan Lee

Genes (Basel)· August 2020

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Casein Kinase 1α as a Regulator of Wnt-Driven Cancer.
Chen Shen, Anmada Nayak, Ricardo A Melendez, Daniel T Wynn, Joshua Jackson, David J Robbins

Int J Mol Sci· August 2020

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The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling.
Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, David J Robbins

Oncotarget· August 2020

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The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors.
Govindi J Samaranayake, Clara I Troccoli, Ling Zhang, Mai Huynh, Christina J Jayaraj, David J Robbins

Mol Cancer Ther· February 2020

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The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α.
Chen Shen, Bin Li, Luisana Astudillo, Murray P Deutscher, Melanie H Cobb, David J Robbins

Biochemistry· December 2019

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Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue.
Lisa A McPherson, Clara I Troccoli, Debin Ji, Annie E Bowles, Makelle L Gardiner, David J Robbins

DNA Repair (Amst)· November 2019

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Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study.
Emily F Winterbottom, Yuguang Ban, Xiaodian Sun, Anthony J Capobianco, Carmen J Marsit, David J Robbins

Environ Health· November 2019

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APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma.
Heng Lu, Ajaz A Bhat, Dunfa Peng, Zheng Chen, Shoumin Zhu, David J Robbins

Cancer Res· September 2019

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