Publications by authors named "David Koss"

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A modified α-synuclein seed amplification assay in Lewy body dementia using Raman spectroscopy and machine learning analysis.
Nathan P Coles, Suzan Elsheikh, Alaa Gouda, Agathe Quesnel, Lucy Butler, David J Koss

J Neurosci Methods· January 2026

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Nuclear Alpha-Synuclein: Mechanisms and Implications for Synucleinopathies.
Tiago Fleming Outeiro, David J Koss

Mov Disord· November 2025

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Alpha-synuclein aggregation induces prominent cellular lipid changes as revealed by Raman spectroscopy and machine learning analysis.
Nathan P Coles, Suzan Elsheikh, Agathe Quesnel, Lucy Butler, Ojodomo Achadu, David J Koss

Brain Commun· April 2025

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A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies.
David J Koss, Olivia Todd, Hariharan Menon, Zoe Anderson, Tamsin Yang

Mol Neurodegener· March 2025

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Molecular Insights into α-Synuclein Fibrillation: A Raman Spectroscopy and Machine Learning Approach.
Nathan P Coles, Suzan Elsheikh, Agathe Quesnel, Lucy Butler, Claire Jennings, David J Koss

ACS Chem Neurosci· February 2025

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Altered hippocampal doublecortin expression in Parkinson's disease.
Evelini Plácido, David J Koss, Tiago Fleming Outeiro, Patricia S Brocardo

J Neurochem· August 2024

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Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change.
Nauman Malik, Mohi-Uddin Miah, Alessandro Galgani, Kirsty McAleese, Lauren Walker, David J Koss

Acta Neuropathol· February 2024

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Blood mRNA Expression in Alzheimer's Disease and Dementia With Lewy Bodies.
Paul C Donaghy, Simon J Cockell, Carmen Martin-Ruiz, Jonathan Coxhead, Joseph Kane, David Koss

Am J Geriatr Psychiatry· September 2022

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Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies.
David J Koss, Daniel Erskine, Andrew Porter, Pawel Palmoski, Hariharan Menon

Acta Neuropathol Commun· July 2022

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Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Christopher Hatton, Simona S Ghanem, David J Koss, Ilham Y Abdi, Elizabeth Gibbons

Brain· May 2022

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Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer's Disease.
Kate L Jordan, David J Koss, Tiago F Outeiro, Flaviano Giorgini

Biomedicines· May 2022

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Frontal white matter lesions in Alzheimer's disease are associated with both small vessel disease and AD-associated cortical pathology.
Kirsty E McAleese, Mohi Miah, Sophie Graham, Georgina M Hadfield, Lauren Walker, David Koss

Acta Neuropathol· December 2021

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Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases.
David J Koss, Susanna Campesan, Flaviano Giorgini, Tiago F Outeiro

Mov Disord· August 2021

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Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders.
Daniel Erskine, David Koss, Viktor I Korolchuk, Tiago F Outeiro, Johannes Attems

Acta Neuropathol· April 2021

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RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies.
David J Koss, Odeta Bondarevaite, Sara Adams, Marta Leite, Flaviano Giorgini

Brain Pathol· January 2021

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Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer's Disease.
Heather Buchanan, Murray Mackay, Kerri Palmer, Karolína Tothová, Miroslava Katsur, David J Koss

Mol Neurobiol· August 2020

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Synucleinopathies: Where we are and where we need to go.
Inês Caldeira Brás, Antonio Dominguez-Meijide, Ellen Gerhardt, David Koss, Diana F Lázaro

J Neurochem· May 2020

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Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia.
Claire Hull, Ruta Dekeryte, David J Koss, Barry Crouch, Heather Buchanan

Mol Neurobiol· January 2020

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In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies.
Amir Tayaranian Marvian, David J Koss, Farhang Aliakbari, Dina Morshedi, Tiago Fleming Outeiro

J Neurochem· September 2019

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Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
Éva M Szegő, Antonio Dominguez-Meijide, Ellen Gerhardt, Annekatrin König, David J Koss

Cell Rep· July 2019

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Dementia with Lewy bodies: an update and outlook.
Tiago Fleming Outeiro, David J Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi

Mol Neurodegener· January 2019

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Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer's disease.
David J Koss, Marina Dubini, Heather Buchanan, Claire Hull, Bettina Platt

Brain Res· November 2018

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Alzheimer's disease pathology and the unfolded protein response: prospective pathways and therapeutic targets.
David J Koss, Bettina Platt

Behav Pharmacol· April 2017

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Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.
David J Koss, Glynn Jones, Anna Cranston, Heidi Gardner, Nicholas M Kanaan

Acta Neuropathol· December 2016

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Neuronal human BACE1 knockin induces systemic diabetes in mice.
Kaja Plucińska, Ruta Dekeryte, David Koss, Kirsty Shearer, Nimesh Mody

Diabetologia· July 2016

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