Publications by authors named "David L Jakeman"

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Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics.
Elisa Ospanow, Oscar L Alferez, David L Jakeman

Chemistry· December 2025

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Inhibition of glycoprotein biosynthesis in the pathogenic bacterium by masked carbohydrate phosphonates.
Ebrahim Soleimani, Aniqa Chowdhury, Jian-She Zhu, Elisa Ospanow, Karen D Moulton, David L Jakeman

Chem Commun (Camb)· December 2025

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Synthesis and physicochemical evaluation of phosphorus(III) and phosphorus(V) substituted benzoxaboroles.
Elisa Ospanow, Mirele Barsoum, David L Jakeman

Org Biomol Chem· September 2025

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Amino-acid derived benzazaboroles: structure and function of a new chemotype.
Cyril J O'Brien, Elisa Ospanow, Karin Reznikov, Ebrahim Soleimani, Martin Lanteigne, David L Jakeman

Org Biomol Chem· August 2025

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Acquired resistance to jadomycin B in human triple-negative breast cancer cells is associated with increased cyclooxygenase-2 expression.
Brendan T McKeown, Brandon Groves, David L Jakeman, Kerry B Goralski

J Pharmacol Exp Ther· May 2025

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A novel bis-phosphonyl C-glycoside: the first synthesis of C-(1,6-deoxy-β-D-glucopyranosyl)dimethylphosphonate, a stable bisphosphonate to probe the mechanism of β-phosphoglucomutase.
Ramprasad Ghosh, David L Jakeman

Org Biomol Chem· January 2025

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Synthesis of the O antigen repeating units of Escherichia coli serotypes O117 and O107.
Dylan Falconer, Jacob Melamed, Alexander Kocev, Maike Bossert, David L Jakeman

Glycobiology· December 2024

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BODIPYs α-appended with distyryl-linked aryl bisboronic acids: single-step cell staining and turn-on fluorescence binding with D-glucose.
Adil Alkaş, Joshua M Kofsky, Em C Sullivan, Daisy Nebel, Katherine N Robertson, David L Jakeman

Org Biomol Chem· September 2024

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Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro-β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β-phosphoglucomutase.
Madison Carroll-Poehls, David L Jakeman

Carbohydr Res· December 2023

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Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models.
Brendan T McKeown, Nicholas J Relja, Steven R Hall, Simon Gebremeskel, Jeanna M MacLeod, David L Jakeman

Can J Physiol Pharmacol· April 2023

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5'-Chalcogen-Substituted Nucleoside Pyrophosphate and Phosphate Monoester Analogues: Preparation and Hydrolysis Studies.
Satu Mikkola, Olga Eguaogie, Anu Nieminen, Patrick F Conlon, David L Jakeman

Int J Mol Sci· December 2022

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Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models.
Brendan T McKeown, Nicholas J Relja, Steven R Hall, Simon Gebremeskel, Jeanna M MacLeod, David L Jakeman

Can J Physiol Pharmacol· November 2022

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Synthesis of 5'-Thymidine-Conjugated Formylphenylboronic Acids as Potential Lysine Targeting Iminoboronate Reversible Covalent Enzyme Probes.
Alana M M Rangaswamy, Michael H R Beh, Ebrahim Soleimani, Steve Sequeira, Julie Cormier, David L Jakeman

J Org Chem· November 2022

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Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria-causing parasites.
Philip M Frasse, Justin J Miller, Alexander J Polino, Ebrahim Soleimani, Jian-She Zhu, David L Jakeman

J Biol Chem· February 2022

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A missense variant remote from the active site impairs stability of human phosphoglucomutase 1.
Kyle M Stiers, Reed P Hansen, Bana A Daghlas, Kelly N Mason, Jian-She Zhu, David L Jakeman

J Inherit Metab Dis· July 2020

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On the Catalytic Activity of a GT1 Family Glycosyltransferase from ISP5230.
Stephanie M Forget, Sydney B Shepard, Ebrahim Soleimani, David L Jakeman

J Org Chem· September 2019

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Inhibitory Evaluation of αPMM/PGM from : Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study.
Jian-She Zhu, Kyle M Stiers, Ebrahim Soleimani, Brandon R Groves, Lesa J Beamer, David L Jakeman

J Org Chem· August 2019

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Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated d-Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition.
Jian-She Zhu, Kyle M Stiers, Sherany M Winter, Anthony D Garcia, Antoine F Versini, David L Jakeman

ACS Omega· April 2019

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Structural and dynamical description of the enzymatic reaction of a phosphohexomutase.
Kyle M Stiers, Abigail C Graham, Jian-She Zhu, David L Jakeman, Jay C Nix

Struct Dyn· March 2019

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Isolation of a jadomycin incorporating L-ornithine, analysis of antimicrobial activity and jadomycin reactive oxygen species (ROS) generation in MDA-MB-231 breast cancer cells.
Stephanie M Forget, Andrew W Robertson, Steven R Hall, Jeanna M MacLeod, David P Overy, David L Jakeman

J Antibiot (Tokyo)· August 2018

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Correction: Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues.
Stephanie M Forget, Camilo F Martinez-Farina, David L Jakeman

Chem Commun (Camb)· April 2018

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Post Polyketide Synthase Carbon-Carbon Bond Formation in Type-II PKS-Derived Natural Products from Streptomyces venezuelae.
Andrew W Robertson, Jeanna M MacLeod, Logan W MacIntyre, Stephanie M Forget, Steven R Hall, David L Jakeman

J Org Chem· February 2018

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Observing enzyme ternary transition state analogue complexes by F NMR spectroscopy.
Anna Ampaw, Madison Carroll, Jill von Velsen, Debabrata Bhattasali, Alejandro Cohen, David L Jakeman

Chem Sci· December 2017

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Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells.
Steven R Hall, Jay Toulany, Leah G Bennett, Camilo F Martinez-Farina, Andrew W Robertson, David L Jakeman

J Pharmacol Exp Ther· November 2017

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Furan and Lactam Jadomycin Biosynthetic Congeners Isolated from Streptomyces venezuelae ISP5230 Cultured with N-Trifluoroacetyl-l-lysine.
Stephanie M Forget, Andrew W Robertson, David P Overy, Russell G Kerr, David L Jakeman

J Nat Prod· June 2017

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